21 results on '"Guo, Xu"'
Search Results
2. Antimicrobial limonoids from the seeds of Cipadessa cinerascensa.
- Author
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Ya-Nan Tong, Jia Guo, Yu-Feng Chen, and Guo-Xu Zhang
- Subjects
IN vitro studies ,MEDICINAL plants ,ANTI-infective agents ,NUCLEAR magnetic resonance spectroscopy ,HYDROCARBONS ,PHYTOCHEMICALS ,SEEDS ,MOLECULAR structure ,PLANT extracts ,PHARMACODYNAMICS - Abstract
Phytochemical investigation on the 90% EtOH extract of the seeds of Cipadessa cinerascensa led to the isolation of three new limonoids, cinerascenoids A-C (1-3). Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (¹H-¹H COSY, HMQC, and HMBC) NMR spectroscopy. All the limonoids were in vitro evaluated for their antimicrobial activities against six pathogenic microorganisms. Limonoids 1 and 2 exhibited some activities against three Gram negative bacteria with MIC values less than 60μg/ml. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
3. A new steroidal saponin from Polygonatum sibiricum
- Author
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Xudong Xu, Haifeng Wu, Hong-Yang Zhang, Guo-Xu Ma, Wei-Cheng Hu, Xiaobo Sun, and Zhu Nailiang
- Subjects
Polygonatum sibiricum ,Saponin ,Pharmaceutical Science ,030226 pharmacology & pharmacy ,01 natural sciences ,Analytical Chemistry ,03 medical and health sciences ,0302 clinical medicine ,Asparagaceae ,Drug Discovery ,Humans ,Pharmacology ,chemistry.chemical_classification ,Molecular Structure ,biology ,Traditional medicine ,010405 organic chemistry ,Chemistry ,Polygonatum ,Organic Chemistry ,Hep G2 Cells ,General Medicine ,Saponins ,biology.organism_classification ,Antineoplastic Agents, Phytogenic ,Isoflavones ,0104 chemical sciences ,Complementary and alternative medicine ,Molecular Medicine ,Drug Screening Assays, Antitumor ,Rhizome - Abstract
A new furostan type steroidal saponin, kingianoside Z (1), along with four known compounds (2-5), was isolated from the ethanolic extract of Polygonatum sibiricum Delar. ex Redoute. Their structures were determined by spectroscopical method and by comparison with previously reported spectroscopic data. Compounds 3-5 showed significant cytotoxicity against HepG2 cell lines with IC
- Published
- 2017
4. Two new daphnane diterpenes from the roots of Stelleropsis tianschanica
- Author
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Jun-Shan Yang, Lei-Ling Shi, Jian-Wei Han, Guo-Xu Ma, Jing Zhang, Dan Zhao, Xiong-Fei Guo, and Xu Jianguo
- Subjects
Models, Molecular ,Pharmacology ,Magnetic Resonance Spectroscopy ,Molecular Structure ,010405 organic chemistry ,Chemistry ,Stereochemistry ,Organic Chemistry ,Pharmaceutical Science ,General Medicine ,Antineoplastic Agents, Phytogenic ,Plant Roots ,01 natural sciences ,0104 chemical sciences ,Analytical Chemistry ,010404 medicinal & biomolecular chemistry ,Complementary and alternative medicine ,Cell Line, Tumor ,Drug Discovery ,Humans ,Molecular Medicine ,Spectral analysis ,Diterpenes ,Drug Screening Assays, Antitumor ,Drugs, Chinese Herbal - Abstract
Two new daphnane diterpenes named tianchaterpenes A and B were isolated from the roots of Stelleropsis tianschanica. Their structures were elucidated on the basis of chemical and spectral analysis, including 1D, 2D NMR analyses and HRESIMS. Compounds 1 and 2 were evaluated for their cytotoxic activities against HeLa and HCT-8 cell lines. The results showed that all compounds displayed weak cytotoxicities to the HeLa cells and were inactive to the HCT-8 cells.
- Published
- 2017
5. The new steroidal glycosides from the aerial parts of Lepidogrammitis drymoglossoides
- Author
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Jun-Shan Yang, He Jianwu, Chen Gongxi, Li Gui, Hai Jiang, Hua Long, Wei Hua, Guo-Xu Ma, and Liu Zhuxiang
- Subjects
Steroidal glycosides ,Stereochemistry ,Pharmaceutical Science ,01 natural sciences ,Analytical Chemistry ,HeLa ,Drug Discovery ,Humans ,Glycosides ,Cytotoxicity ,Nuclear Magnetic Resonance, Biomolecular ,Pharmacology ,chemistry.chemical_classification ,Molecular Structure ,biology ,010405 organic chemistry ,Lepidogrammitis drymoglossoides ,Organic Chemistry ,Phytosterols ,Glycoside ,Ponasteroside D ,Ponasteroside C ,General Medicine ,Plant Components, Aerial ,biology.organism_classification ,Antineoplastic Agents, Phytogenic ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Complementary and alternative medicine ,chemistry ,Molecular Medicine ,Drug Screening Assays, Antitumor ,Two-dimensional nuclear magnetic resonance spectroscopy ,Drugs, Chinese Herbal ,HeLa Cells - Abstract
Two new steroidal glycosides ponasteroside C (1) and ponasteroside D (2) were isolated from the aerial parts of Lepidogrammitis drymoglossoides. Their structures were elucidated by various spectroscopic techniques (IR, HRESIMS, 1D and 2D NMR). All compounds were evaluated for their cytotoxicity against HeLa and HCT-8 cell lines, and compounds 1 and 2 showed mild activity against all the test cell lines.
- Published
- 2016
6. Three new polyunsaturated lipids from a Guangxi marine sponge Haliclona sp
- Author
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Guo-Sheng Xing, He Li, Qiong Gu, Rong Xu, Hong-Quan Duan, De-Jun Jin, Sheng-An Tang, Jing Zhou, Wei-Guo Xu, and Chuan Zhao
- Subjects
China ,Haliclona sp ,Stereochemistry ,Pharmaceutical Science ,Marine Biology ,Analytical Chemistry ,Mice ,Haliclona ,Drug Discovery ,Botany ,Animals ,Nuclear Magnetic Resonance, Biomolecular ,Chromatography, High Pressure Liquid ,Pharmacology ,Molecular Structure ,biology ,Chemistry ,Macrophages ,Anti-Inflammatory Agents, Non-Steroidal ,Organic Chemistry ,Stereoisomerism ,General Medicine ,biology.organism_classification ,Sponge ,Complementary and alternative medicine ,Fatty Acids, Unsaturated ,Molecular Medicine - Abstract
Three new polyunsaturated lipids, (6Z,9Z,12Z,15Z)-octadeca-6,9,12,15-tetraen-3-one (1), (6Z,9Z,12Z,15Z)-1-bromooctadeca-6,9,12,15-tetraen-3-one (2), and (Z)-ethyl docos-5-enoate (3), together with two known polyunsaturated lipids, 4(Z),7(Z),10(Z)-tridecatrienoic acid (4) and (6Z,9Z,12Z,15Z)-octadeca-1,6,9,12,15-pentaen-3-one (5), were isolated from the marine sponge Haliclona sp., which was collected from Guangxi, using HSCCC and HPLC methods. Chemical structures of the five compounds were elucidated by spectroscopic techniques.
- Published
- 2014
7. Soulieoside O, a new cyclolanostane triterpenoid glycoside from Souliea vaginata
- Author
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Zi-Jian Zhao, Xiaopo Zhang, Yi-Lin Liu, Peng-Fei Li, Yin-Di Zhu, Qiong-Yu Zou, Haifeng Wu, Zheng-Hong Luo, Guo-Xu Ma, Xudong Xu, and Di-Zhao Chen
- Subjects
Stereochemistry ,Pharmaceutical Science ,01 natural sciences ,Analytical Chemistry ,Inhibitory Concentration 50 ,Triterpenoid ,Drug Discovery ,Ic50 values ,Souliea vaginata ,Humans ,Glycosides ,Cytotoxicity ,Nuclear Magnetic Resonance, Biomolecular ,Pharmacology ,chemistry.chemical_classification ,Molecular Structure ,010405 organic chemistry ,Chemistry ,Organic Chemistry ,Glycoside ,Stereoisomerism ,General Medicine ,Antineoplastic Agents, Phytogenic ,Triterpenes ,0104 chemical sciences ,Rhizome ,010404 medicinal & biomolecular chemistry ,Complementary and alternative medicine ,Cell culture ,Molecular Medicine ,Drug Screening Assays, Antitumor ,Ranunculaceae ,Human cancer ,Drugs, Chinese Herbal - Abstract
A new cyclolanostane triterpenoid glycoside, soulieoside O (1), together with 25-O-acetylcimigenol-3-O-β-d-xylopyranoside (2) and cimigenol-3-O-β-d-xylopyranoside (3), was isolated from the rhizomes of Souliea vaginata. Their structures were characterized by spectroscopic analysis and chemical methods. The new compound showed moderate inhibitory activity against three human cancer cell lines with IC50 values of 9.3–22.5 μM.
- Published
- 2017
8. Oleanane triterpene saponins with cardioprotective activity from Clinopodium polycephalum
- Author
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Wen Zhang, Ze-Xin Ma, Jun-Shan Yang, Wen Sun, Zhu Nailiang, Yu-Xia Hu, Wei Zhang, Xudong Xu, Guo-Xu Ma, Yu Shichun, Yin-Di Zhu, and Kai-Tuo Chen
- Subjects
H9c2 cell ,Cardiotonic Agents ,Pharmaceutical Science ,01 natural sciences ,Analytical Chemistry ,chemistry.chemical_compound ,Triterpene ,Drug Discovery ,Oleanolic Acid ,Oleanane ,Nuclear Magnetic Resonance, Biomolecular ,Clinopodiside VI ,Pharmacology ,chemistry.chemical_classification ,Lamiaceae ,Traditional medicine ,Molecular Structure ,010405 organic chemistry ,Organic Chemistry ,General Medicine ,Hydrogen Peroxide ,Saponins ,Triterpenes ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Complementary and alternative medicine ,chemistry ,Saikosaponin C ,Molecular Medicine ,Clinopodium polycephalum ,Drugs, Chinese Herbal - Abstract
Two new triterpene saponins, clinopodiside VI (1) and saikosaponin c (2), along with six known saikosaponins (3–8), were isolated from the plant of Clinopodium polycephalum. Compounds 1–3 showed moderate inhibition against H9c2 cell damage induced by H2O2.
- Published
- 2016
9. Cassane-type diterpenes from Caesalpinia minax induce apoptosis in pituitary adenoma: structure-activity relationship, ER stress and Wnt/β-catenin pathways
- Author
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Guo-Xu Ma, Wei-ping Li, Ce Zhang, Jun-Shan Yang, Zong-Yang Li, Bao-dong Chen, Qing-Zhong Li, and Lei Chen
- Subjects
0301 basic medicine ,Pharmaceutical Science ,Antineoplastic Agents ,Apoptosis ,Analytical Chemistry ,03 medical and health sciences ,Structure-Activity Relationship ,0302 clinical medicine ,Drug Discovery ,Structure–activity relationship ,Humans ,Pituitary Neoplasms ,Caesalpinia ,Cytotoxicity ,beta Catenin ,Pharmacology ,biology ,Molecular Structure ,Organic Chemistry ,Wnt signaling pathway ,General Medicine ,biology.organism_classification ,Wnt Proteins ,030104 developmental biology ,Complementary and alternative medicine ,Biochemistry ,030220 oncology & carcinogenesis ,Catenin ,Cancer cell ,Seeds ,Unfolded protein response ,Molecular Medicine ,Diterpenes ,Drug Screening Assays, Antitumor ,Drugs, Chinese Herbal - Abstract
Plant-derived natural products have been the highly significant sources of novel antitumor agents. The cassane-type diterpenes of genus Caesalpinia have been reported to bear antiproliferative activities toward different types of cancer cells. In this study, we evaluated the antineoplasmic activities of 16 natural origin cassane-type diterpenes isolated from the CHCl3 extract of the seeds of C. minax in pituitary adenomas cells and identified caesalpin G (CAG) showed the strongest cytotoxicity. Moreover, we further investigated the structure-activity relationship and molecular mechanism of these derivatives systematically. The results confirmed the unsaturated lactone-type ring, hydroxyl at C-7, and alkenyl at C-11 or C-14 functionality as critical for anticancer activity in this family of natural products. In addition, the mechanism experiments also demonstrated unfolded protein response and ER stress and Wnt/β-catenin pathway were involved in the CAG-induced apoptosis.
- Published
- 2016
10. Two new degradative cassane-type diterpenes isolated from Caesalpinia minax
- Author
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Guo-Xu Ma, Jing-Quan Yuan, Zhong-Hao Sun, Guo-Hong Wang, Zhaocui Sun, Hua Wei, Xudong Xu, Haifeng Wu, and Jun-Shan Yang
- Subjects
Bridged-Ring Compounds ,Pharmacology ,Caesalpinia ,Molecular Structure ,biology ,Stereochemistry ,Chemistry ,Organic Chemistry ,Pharmaceutical Science ,General Medicine ,biology.organism_classification ,Caesalpin J ,Analytical Chemistry ,Caesalpinia minax ,Complementary and alternative medicine ,Seeds ,Drug Discovery ,Molecular Medicine ,Diterpenes ,Nuclear Magnetic Resonance, Biomolecular ,Drugs, Chinese Herbal - Abstract
Cassane-type diterpenes are main bioactive constituents of Caesalpinia minax HANCE. As a part of our ongoing chemical investigation of C. minax, two new degradative cassane-type diterpenes, named caesalpins I (1) and J (2), were isolated from the EtOAc extract of the seeds of C. minax. The structures were elucidated by means of spectroscopic analysis.
- Published
- 2013
11. A new phenylethanoid glycoside from Incarvillea compacta
- Author
-
Yin-Di Zhu, Lijing Zhang, Bo-Ran Hu, Li Chen, Qiong-Yu Zou, Guo-Xu Ma, Ting Shen, Haifeng Wu, Xinfeng Wang, Wei-Cheng Hu, and Xudong Xu
- Subjects
Stereochemistry ,DPPH ,Pharmaceutical Science ,Bignoniaceae ,01 natural sciences ,Plant Roots ,Antioxidants ,Analytical Chemistry ,chemistry.chemical_compound ,Cresols ,Phenols ,Picrates ,Drug Discovery ,Humans ,Glycosides ,Carbon Tetrachloride ,Pharmacology ,chemistry.chemical_classification ,biology ,Molecular Structure ,010405 organic chemistry ,Organic Chemistry ,Biphenyl Compounds ,Glycoside ,General Medicine ,Phenylethanoid ,Butylated Hydroxytoluene ,biology.organism_classification ,0104 chemical sciences ,Biphenyl compound ,010404 medicinal & biomolecular chemistry ,Complementary and alternative medicine ,chemistry ,Carbon tetrachloride ,Molecular Medicine ,Epimer - Abstract
A new phenylethanoid glycoside, 3'''-O-methylcampneoside I (1), was isolated from the 90% ethanolic extract of the roots of Incarvillea compacta, together with three known compounds, campneoside I (2), ilicifolioside A (3), and campneoside II (4). Their structures were determined spectroscopically and compared with previously reported spectral data. Compound 1 existed as epimers and displayed better 1,1-diphenyl-2-picrylhydrazyl (DPPH)-free radical scavenging activity using di-tert-butyl-4-methylphenol (BHT) as the positive control. In addition, pretreatment of human HepG2 cells with compound 1 significantly increased the viability on CCl4-induced cell death.
- Published
- 2015
12. A new bis-γ-pyrone polypropionate from a marine pulmonate mollusc Onchidium struma.
- Author
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Chen, De-Li, Zheng, Wei, Feng, Jian, Ma, Guo-Xu, Liu, Yang-Yang, and Xu, Xu-Dong
- Subjects
ANTINEOPLASTIC agents ,BIOLOGICAL assay ,CELL lines ,CHROMATOGRAPHIC analysis ,DOSE-effect relationship in pharmacology ,HETEROCYCLIC compounds ,MARINE animals ,MOLECULAR structure ,MOLLUSKS ,NUCLEAR magnetic resonance spectroscopy ,SPECTROPHOTOMETERS ,SPECTRUM analysis ,CYTOTOXINS ,DESCRIPTIVE statistics - Abstract
A new bis-γ-pyrone polypropionate compound onchidione II (1), together with three known compounds, was isolated from a marine pulmonate mollusc Onchidium struma, collected at Hainan Island of China. The structure of new compound was determined by extensive spectroscopic analyses including IR, 1D and 2D NMR techniques, and chemical methods. Compounds 1–4 were evaluated for their cytotoxicity against human tumor cell lines HepG-2, A549, and MCF-2. The results showed that compounds 1 and 2 were moderate cytotoxic against HepG-2, A549, and MCF-2 cell lines, with IC
50 values from 13.2 to 22.4 μM. [ABSTRACT FROM AUTHOR]- Published
- 2019
- Full Text
- View/download PDF
13. Two new daphnane diterpenes from the roots of Stelleropsis tianschanica.
- Author
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Zhao, Dan, Shi, Lei-Ling, Guo, Xiong-Fei, Ma, Guo-Xu, Han, Jian-Wei, Yang, Jun-Shan, Xu, Jian-Guo, and Zhang, Jing
- Subjects
CELL lines ,HYDROCARBON analysis ,APOPTOSIS ,HERBAL medicine ,HYDROCARBONS ,CHINESE medicine ,MOLECULAR structure ,PLANT roots ,STATISTICS ,PHYTOCHEMICALS ,DATA analysis ,PHYSIOLOGY - Abstract
Two new daphnane diterpenes named tianchaterpenes A and B were isolated from the roots of Stelleropsis tianschanica. Their structures were elucidated on the basis of chemical and spectral analysis, including 1D, 2D NMR analyses and HRESIMS. Compounds 1 and 2 were evaluated for their cytotoxic activities against HeLa and HCT-8 cell lines. The results showed that all compounds displayed weak cytotoxicities to the HeLa cells and were inactive to the HCT-8 cells. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
14. A new ursane-type triterpene, cymosic acid from Rosa cymosa
- Author
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Xiao-Yan Huang, Jun-Shan Yang, Xiao-Peng Wu, Xudong Xu, Jing-Quan Yuan, Xiao-Ming Zhong, Mu-Die Xu, Mo Han, Haifeng Wu, Zhen Huang, Guo-Xu Ma, and Xiaopo Zhang
- Subjects
Lipopolysaccharides ,Stereochemistry ,Pharmaceutical Science ,Nitric Oxide ,Rosa ,Analytical Chemistry ,Nitric oxide ,chemistry.chemical_compound ,Mice ,Rosa cymosa ,Triterpene ,Drug Discovery ,Animals ,Nuclear Magnetic Resonance, Biomolecular ,Pharmacology ,chemistry.chemical_classification ,biology ,Molecular Structure ,Macrophages ,Organic Chemistry ,Macrophage cell ,General Medicine ,Carbon-13 NMR ,biology.organism_classification ,Triterpenes ,Complementary and alternative medicine ,chemistry ,Molecular Medicine ,Cymosic acid ,Two-dimensional nuclear magnetic resonance spectroscopy ,Heteronuclear single quantum coherence spectroscopy ,Drugs, Chinese Herbal - Abstract
A new ursane-type triterpene, cymosic acid (1) together with two known compounds, 3β,19α-dihydroxy-2-oxo-12-ursen-28-oic acid (2) and 2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid (3), were isolated from Rosa cymosa Tratt. The structure of compound 1 was elucidated by analyzing its 1H and 13C NMR, 1H–1H COSY, HSQC, HMBC, NOESY, and HR-ESI-MS values. The three compounds were found to display moderate inhibitory activities against nitric oxide production in lipopolysaccharide-activated macrophage cell lines, RAW 264.7 cells.
- Published
- 2014
15. Cytotoxic lanostane triterpenoids from the stems of Schisandra glaucescens.
- Author
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Liu, Yan, Hu, Jiang, Lv, Yan, Huang, Xiao-Yun, and Zhang, Guo-Xu
- Subjects
ANTINEOPLASTIC agents ,CELL lines ,CELL surface antigens ,CHROMATOGRAPHIC analysis ,HIGH performance liquid chromatography ,IMMUNODIAGNOSIS ,MOLECULAR structure ,NUCLEAR magnetic resonance spectroscopy ,STATISTICS ,TERPENES ,PLANT extracts ,DATA analysis ,PLANT anatomy ,IN vitro studies - Abstract
Phytochemical investigation on the stems of Schisandra glaucescens resulted into the isolation of three new lanostane triterpenoids, 12-hydroxyschiglausin B (1), 12-hydroxykadsuphilactone B (2), and 20R-hydroxyschinalactone C (3). Structural elucidation of all the compounds was accomplished by spectral methods. The isolated compounds were tested in vitro for cytotoxic activities. As a result, triterpenoids 1 and 2 showed cytotoxic activities for all six tested tumor cell lines with IC
50 values less than 15 μM. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
- View/download PDF
16. A new steroidal saponin from Polygonatum sibiricum.
- Author
-
Zhang, Hong-Yang, Hu, Wei-Cheng, Ma, Guo-Xu, Zhu, Nai-Liang, Sun, Xiao-Bo, Wu, Hai-Feng, and Xu, Xu-Dong
- Subjects
CELL lines ,COMPARATIVE studies ,HEPATOCELLULAR carcinoma ,LIVER tumors ,MEDICINAL plants ,MOLECULAR structure ,RESEARCH funding ,SPECTRUM analysis ,STEROIDS ,PHYTOCHEMICALS ,PLANT extracts ,CYTOTOXINS - Abstract
A new furostan type steroidal saponin, kingianoside Z (1), along with four known compounds (2-5), was isolated from the ethanolic extract of Polygonatum sibiricum Delar. ex Redoute. Their structures were determined by spectroscopical method and by comparison with previously reported spectroscopic data. Compounds 3-5 showed significant cytotoxicity against HepG2 cell lines with IC
50 values of 14.2, 12.1 and 8.5 μM, respectively. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
- View/download PDF
17. Two new diterpenes, neocaesalpin MR and minaxin C, from Caesalpinia minax
- Author
-
Na Xu, Jun-Shan Yang, Xudong Xu, Qingxia Zheng, Zhaocui Sun, Jing-Quan Yuan, Hua Wei, and Guo-Xu Ma
- Subjects
Colorectal cancer ,Pharmaceutical Science ,Analytical Chemistry ,HeLa ,Nuclear magnetic resonance ,Neocaesalpin MR ,Drug Discovery ,medicine ,Humans ,Nuclear Magnetic Resonance, Biomolecular ,Pharmacology ,Caesalpinia ,biology ,Molecular Structure ,Chemistry ,Organic Chemistry ,General Medicine ,biology.organism_classification ,medicine.disease ,Molecular biology ,Antineoplastic Agents, Phytogenic ,Caesalpinia minax ,Complementary and alternative medicine ,Molecular Medicine ,Diterpenes ,Drug Screening Assays, Antitumor ,Human cancer ,Drugs, Chinese Herbal - Abstract
Two new cassane-type diterpenes, neocaesalpin MR (1) and minaxin C (2), were isolated from Caesalpinia minax HANCE. The structures of these compounds were elucidated by means of spectroscopic analysis. Among these isolated compounds, neocaesalpin MR showed mild activities toward HeLa and colon cancer (HCT-8) human cancer cell lines.
- Published
- 2012
18. Cassane-type diterpenes from Caesalpinia minax induce apoptosis in pituitary adenoma: structure–activity relationship, ER stress and Wnt/β-catenin pathways.
- Author
-
Li, Zong-Yang, Li, Qing-Zhong, Ma, Guo-Xu, Chen, Lei, Zhang, Ce, Chen, Bao-dong, Yang, Jun-Shan, and Li, Wei-Ping
- Subjects
ANIMAL experimentation ,ANTINEOPLASTIC agents ,APOPTOSIS ,BIOLOGICAL assay ,CELL culture ,CELL lines ,CELL physiology ,CELLULAR signal transduction ,CYTOSKELETAL proteins ,ENDOPLASMIC reticulum ,FLAVONOIDS ,FLOW cytometry ,LACTATE dehydrogenase ,MICE ,MOLECULAR structure ,PITUITARY tumors ,PROBABILITY theory ,PROTEOLYTIC enzymes ,RESEARCH funding ,STAINS & staining (Microscopy) ,STATISTICS ,PHYSIOLOGICAL stress ,T-test (Statistics) ,TERPENES ,TOXICITY testing ,WESTERN immunoblotting ,PLANT extracts ,DATA analysis ,WNT proteins ,DESCRIPTIVE statistics ,TEMOZOLOMIDE ,ONE-way analysis of variance - Abstract
Plant-derived natural products have been the highly significant sources of novel antitumor agents. The cassane-type diterpenes of genusCaesalpiniahave been reported to bear antiproliferative activities toward different types of cancer cells. In this study, we evaluated the antineoplasmic activities of 16 natural origin cassane-type diterpenes isolated from the CHCl3extract of the seeds ofC. minaxin pituitary adenomas cells and identified caesalpin G (CAG) showed the strongest cytotoxicity. Moreover, we further investigated the structure–activity relationship and molecular mechanism of these derivatives systematically. The results confirmed the unsaturated lactone-type ring, hydroxyl at C-7, and alkenyl at C-11 or C-14 functionality as critical for anticancer activity in this family of natural products. In addition, the mechanism experiments also demonstrated unfolded protein response and ER stress and Wnt/β-catenin pathway were involved in the CAG-induced apoptosis. [ABSTRACT FROM PUBLISHER]
- Published
- 2017
- Full Text
- View/download PDF
19. A new ursane-type triterpene, cymosic acid from Rosa cymosa.
- Author
-
Wu, Xiao-Peng, Zhang, Xiao-Po, Ma, Guo-Xu, Han, Mo, Xu, Mu-Die, Wu, Hai-Feng, Huang, Xiao-Yan, Huang, Zhen, Yang, Jun-Shan, Yuan, Jing-Quan, Xu, Xu-Dong, and Zhong, Xiao-Ming
- Subjects
ANIMAL experimentation ,BIOLOGICAL assay ,CELL culture ,HIGH performance liquid chromatography ,MASS spectrometry ,MICE ,MOLECULAR structure ,NITRIC oxide ,NUCLEAR magnetic resonance spectroscopy ,RESEARCH funding ,TERPENES ,PLANT extracts ,LIPOPOLYSACCHARIDES ,DESCRIPTIVE statistics - Abstract
A new ursane-type triterpene, cymosic acid (1) together with two known compounds, 3β,19α-dihydroxy-2-oxo-12-ursen-28-oic acid (2) and 2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid (3), were isolated from Rosa cymosa Tratt. The structure of compound 1 was elucidated by analyzing its
1 H and13 C NMR,1 H–1 H COSY, HSQC, HMBC, NOESY, and HR-ESI-MS values. The three compounds were found to display moderate inhibitory activities against nitric oxide production in lipopolysaccharide-activated macrophage cell lines, RAW 264.7 cells. [ABSTRACT FROM AUTHOR]- Published
- 2014
- Full Text
- View/download PDF
20. Two new degradative cassane-type diterpenes isolated from Caesalpinia minax.
- Author
-
Sun, Zhao-Cui, Ma, Guo-Xu, Yuan, Jing-Quan, Wei, Hua, Wu, Hai-Feng, Sun, Zhong-Hao, Wang, Guo-Hong, Yang, Jun-Shan, and Xu, Xu-Dong
- Subjects
- *
CHROMATOGRAPHIC analysis , *INFRARED spectroscopy , *MASS spectrometry , *MOLECULAR structure , *NUCLEAR magnetic resonance spectroscopy , *PHARMACEUTICAL chemistry , *RESEARCH funding , *TERPENES , *PLANT extracts - Abstract
Cassane-type diterpenes are main bioactive constituents of Caesalpinia minax HANCE. As a part of our ongoing chemical investigation of C. minax, two new degradative cassane-type diterpenes, named caesalpins I (1) and J (2), were isolated from the EtOAc extract of the seeds of C. minax. The structures were elucidated by means of spectroscopic analysis. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
21. Two new diterpenes, neocaesalpin MR and minaxin C, from Caesalpinia minax.
- Author
-
Ma, Guo-Xu, Xu, Na, Yuan, Jing-Quan, Wei, Hua, Zheng, Qing-Xia, Sun, Zhao-Cui, Yang, Jun-Shan, and Xu, Xu-Dong
- Subjects
- *
BIOLOGICAL assay , *CELL culture , *MOLECULAR structure , *NUCLEAR magnetic resonance spectroscopy , *PHARMACEUTICAL chemistry , *RESEARCH funding , *TERPENES , *THIN layer chromatography , *PLANT extracts - Abstract
Two new cassane-type diterpenes, neocaesalpin MR (1) and minaxin C (2), were isolated from Caesalpinia minax HANCE. The structures of these compounds were elucidated by means of spectroscopic analysis. Among these isolated compounds, neocaesalpin MR showed mild activities toward HeLa and colon cancer (HCT-8) human cancer cell lines. [ABSTRACT FROM PUBLISHER]
- Published
- 2012
- Full Text
- View/download PDF
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