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A new ursane-type triterpene, cymosic acid from Rosa cymosa
- Source :
- Journal of Asian natural products research. 16(4)
- Publication Year :
- 2014
-
Abstract
- A new ursane-type triterpene, cymosic acid (1) together with two known compounds, 3β,19α-dihydroxy-2-oxo-12-ursen-28-oic acid (2) and 2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid (3), were isolated from Rosa cymosa Tratt. The structure of compound 1 was elucidated by analyzing its 1H and 13C NMR, 1H–1H COSY, HSQC, HMBC, NOESY, and HR-ESI-MS values. The three compounds were found to display moderate inhibitory activities against nitric oxide production in lipopolysaccharide-activated macrophage cell lines, RAW 264.7 cells.
- Subjects :
- Lipopolysaccharides
Stereochemistry
Pharmaceutical Science
Nitric Oxide
Rosa
Analytical Chemistry
Nitric oxide
chemistry.chemical_compound
Mice
Rosa cymosa
Triterpene
Drug Discovery
Animals
Nuclear Magnetic Resonance, Biomolecular
Pharmacology
chemistry.chemical_classification
biology
Molecular Structure
Macrophages
Organic Chemistry
Macrophage cell
General Medicine
Carbon-13 NMR
biology.organism_classification
Triterpenes
Complementary and alternative medicine
chemistry
Molecular Medicine
Cymosic acid
Two-dimensional nuclear magnetic resonance spectroscopy
Heteronuclear single quantum coherence spectroscopy
Drugs, Chinese Herbal
Subjects
Details
- ISSN :
- 14772213
- Volume :
- 16
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of Asian natural products research
- Accession number :
- edsair.doi.dedup.....69feab9c37e2a2b867899a552218b1f2