A new ursane-type triterpene, cymosic acid from Rosa cymosa.

Authors :: Wu, Xiao-Peng
Zhang, Xiao-Po
Ma, Guo-Xu
Han, Mo
Xu, Mu-Die
Wu, Hai-Feng
Huang, Xiao-Yan
Huang, Zhen
Yang, Jun-Shan
Yuan, Jing-Quan
Xu, Xu-Dong
Zhong, Xiao-Ming
Source :: Journal of Asian Natural Products Research; Apr2014, Vol. 16 Issue 4, p422-425, 4p
Publication Year :: 2014
Abstract: A new ursane-type triterpene, cymosic acid (1) together with two known compounds, 3β,19α-dihydroxy-2-oxo-12-ursen-28-oic acid (2) and 2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid (3), were isolated from Rosa cymosa Tratt. The structure of compound 1 was elucidated by analyzing its <superscript>1</superscript>H and <superscript>13</superscript>C NMR, <superscript>1</superscript>H–<superscript>1</superscript>H COSY, HSQC, HMBC, NOESY, and HR-ESI-MS values. The three compounds were found to display moderate inhibitory activities against nitric oxide production in lipopolysaccharide-activated macrophage cell lines, RAW 264.7 cells. [ABSTRACT FROM AUTHOR]