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A recent preprint abstract discusses the role of lipid bilayers in regulating the binding of cyclic adenosine monophosphate (cAMP) to pacemaker channels in the human heart. The study found that lipid membranes promote cooperative binding of cAMP to HCN channels without changing the intrinsic binding affinity. This research highlights the importance of lipid membranes in enhancing the gating sensitivity of ion channels. The preprint has not yet undergone peer review. [Extracted from the article]

Researchers at Northwestern Polytechnic University in Shaanxi, China, have developed a new method using supramolecular protein assemblies to address memory deficits in an Alzheimer's disease mouse model. These protein assemblies can cross the blood-brain barrier, recognize and eliminate amyloid plaques, promote neurogenesis, and improve cognitive function. This innovative approach opens up possibilities for designing intelligent supramolecular biomaterials for treating neurodegenerative diseases. The study was supported by the National Natural Science Foundation of China and has been peer-reviewed. [Extracted from the article]

Researchers from the Massachusetts Institute of Technology have developed magnetoelectric nanodiscs that enable wireless transgene-free neuromodulation. These nanodiscs, known as MENDs, have shown robust responses to magnetic field stimulation in neurons, allowing for remote control of reward or motor behaviors in genetically intact mice. The study suggests that this minimally invasive neuromodulation technique could have significant applications in neuroscience research and treatment. The research was funded by various organizations including the National Institutes of Health and the European Innovation Council. [Extracted from the article]

The article discusses a study on nanopharmaceuticals conducted by the Institute for Advanced Research, focusing on the functionalization of vortex nanodiscs to overcome macrophage recognition for efficient theragnosis applications. The research highlights the challenges faced by nanotherapeutics in successfully accumulating at target cells due to biological barriers. By synthesizing biocompatible multilayered nanodiscs with inert surface modifications, the study aims to reduce macrophage uptake while maintaining biocompatibility, paving the way for the development of specific nanotherapeutics. The research offers insights into innovative design features that can be incorporated to enhance the effectiveness of nanodiscs in diagnosis and treatment responses. [Extracted from the article]

Researchers from Kangwon National University in Gangwon Do, South Korea, have developed a hybrid gel system combining organic nanorods and inorganic nanodisks for localized cancer therapy. This system integrates starvation therapy, chemodynamic therapy, and photothermal therapy to target cancer cells effectively. The gel, containing Indocyanine green, glucose oxidase, and copper(II) sulfate, showed promising results in suppressing tumor growth and inducing apoptosis in colorectal cancer cells. The study highlights the potential of nanotechnology in improving cancer treatment outcomes. [Extracted from the article]

Researchers from the Technical University of Denmark have developed a new workflow for characterizing the function of transporters using nanodiscs. The workflow combines cell-free protein synthesis and solid supported membrane-based electrophysiology, allowing for a direct functional assessment of transporter protein activity. The researchers validated this workflow by expressing and characterizing five diverse transporters. This new method offers a convenient and expedited way to assess transporter protein activity, with potential applications in medical and biotechnological research. [Extracted from the article]

Researchers at the Russian Academy of Sciences have highlighted the potential of using antibodies to target complex membrane proteins for drug discovery. Membrane proteins are attractive targets for drug development, but they present challenges due to their biological importance. The researchers discuss the advantages of using antibodies and lipid nanoparticle systems to simplify the process of discovering therapeutic antibodies. With further research and development, the full potential of therapeutic antibodies targeting complex membrane proteins can be unlocked. [Extracted from the article]

A study conducted by the Chinese Academy of Sciences explores the use of nanodiscs in membrane protein drug discovery and development, as well as drug delivery. Nanodiscs, which are phospholipid bilayer structures, provide a natural environment for maintaining the structure and function of membrane proteins and can serve as a versatile delivery vehicle for various types of drugs. The researchers highlight the advantages and potential applications of nanodiscs in pharmaceutical industries, emphasizing their role in membrane protein research and drug development. This review provides a comprehensive overview of the structural characteristics, advantages, classification, and applications of nanodiscs. [Extracted from the article]

According to a preprint abstract, researchers have found that the mycobacterial membrane protein large 3 (MmpL3) exists as a dimer in various membrane mimetic systems. This is in contrast to previous structures of MmpL3, which indicated that the protein was monomeric. The researchers used biophysical and computational analysis, sucrose gradient separation, native mass spectrometry, cryo-EM analysis, and molecular dynamics simulations to support their findings. The study also revealed that certain lipid classes were predominant in the co-purified lipids of MmpL3. However, it is important to note that this preprint has not yet undergone peer review. [Extracted from the article]

A study conducted by researchers at the University of Ioannina in Greece explored the use of graphene oxide and oxidized carbon nanodiscs as nanocarriers for the targeted delivery of quercetin, a bioactive flavonoid with potent anticancer properties. The researchers found that the conjugation of quercetin to these nanomaterials enhanced its cytotoxic effect on cancer cells, inducing cell cycle arrest and reducing cell viability. However, further research is needed to validate these findings at the molecular level. This study highlights the potential of graphene oxide and oxidized carbon nanodiscs as biomedical scaffolds for targeted anticancer therapy. [Extracted from the article]

A recent study conducted by Fudan University in Shanghai, China, has explored the interaction between lipid-based nanocarriers and plasma proteins in drug delivery. The researchers fabricated discoid-shaped lipid nanodiscs composed of different phospholipids and investigated their stability, biodistribution, and interaction with serum proteins. The results showed that the composition of phospholipids influenced the stability of the nanodiscs in blood serum, with the nanodiscs composed of POPG exhibiting the least stability. However, the phospholipid composition did not affect the nanodiscs' ability to evade accelerated blood clearance. The study also found that the nanodiscs composed of POPC displayed a higher deposition of apolipoprotein E, suggesting their potential for brain-targeted drug delivery. [Extracted from the article]

A recent report from Sichuan University in Chengdu, China discusses the use of enzyme-activatable disk-shaped nanocarriers for breast cancer combination therapy. These nanocarriers, called TRAIL-[ND-HCPT](GAC), were designed to enhance the delivery of hydroxycamptothecin (HCPT) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to tumor tissues. The nanocarriers were found to have better tumor infiltration ability and exhibited synergistic antitumor effects, resulting in improved therapeutic efficacy and prolonged survival in breast tumor-bearing mice. This research provides promising insights into the development of more effective treatments for breast cancer. [Extracted from the article]

Researchers from the Shenzhen Campus of Sun Yat-sen University in China have conducted a study on nanodiscs and their potential for drug delivery. The study focused on the conformational characteristics of Apolipoprotein A-I (apoA-I) peptide analogs (APAs) in nanodisc assembly and their ability to encapsulate curcumin. Molecular dynamic simulations and in vitro assessments were used to evaluate the efficacy of different APA-ND formulations as drug carriers. The findings suggest that APA-NDs have the potential to be a promising platform for drug delivery, with tunable features that can revolutionize nanomedicine. [Extracted from the article]

A study conducted by CHA University in South Korea has provided new data on nanodiscs and their implications for downstream signaling. The research focused on the membrane-driven dimerization of the peripheral membrane protein KRAS, which plays a role in cell proliferation and oncogenesis. The study used lipid-bilayer nanodisc platforms and paramagnetic relaxation enhancement (PRE) analyses to reveal the structures of membrane-bound KRAS homodimers. The findings suggest that nanodisc platforms can be used to screen potential anticancer drugs that target membrane-bound RAS dimers and investigate their structural mechanism of action. [Extracted from the article]

Oxford University Innovation Limited has been issued a patent for a method of detecting membrane proteins using mass spectrometry. The method involves sonication of a vesicle formed from the native membrane of an organism in the presence of a mass spectrometry-compatible buffer. This allows the membrane protein to be detected while still in its native environment, without the use of detergents or harsh chemicals. The invention aims to overcome limitations in traditional structural biology methods and provide a more accurate and sensitive technique for studying membrane proteins and their complexes. [Extracted from the article]

Researchers at Henan Normal University in Xinxiang, People's Republic of China, have developed a tunable fiber optic sensor using nanodiscs that can detect changes in refractive index. The sensor consists of a square lattice array of silver nanodisks on the end face of the fiber optic. The sensor demonstrates high sensitivity and linearity in response to refractive index changes, and the use of nanodisks with different diameters enables the coupling of two resonant modes, enhancing the sensor's capabilities. This research provides a potential option for achieving multifunctionality and miniaturization in sensor platforms. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the potential of magnetoelectric nanodiscs (MENDs) as a less invasive alternative to deep-brain stimulation (DBS) for the treatment of movement disorders and neuroscience studies. The MENDs, with a core-double shell architecture, showed robust responses to magnetic field stimulation in neurons, even at low particle potentials. In experiments with genetically intact mice, MENDs injected into the ventral tegmental area enabled remote control of reward behavior. This research sets the stage for further exploration and optimization of magnetoelectric neuromodulation in the field of neuroscience. Please note that this preprint has not yet undergone peer review. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the molecular determinants that govern the activation of lecithin:cholesterol acyltransferase (LCAT) by different apolipoproteins. The study conducted molecular dynamics simulations of LCAT with nanodiscs made from alpha-helical amphiphilic peptides derived from apolipoproteins A1 and E, as well as an apoA1 mimetic peptide. The researchers found that certain residues in the peptides, such as E4, D4, and R7, were key contributors to the interaction with LCAT. The study also detected novel LCAT binding helices in other plasma proteins. However, it is important to note that this preprint has not been peer-reviewed. [Extracted from the article]

A recent report discusses the development and characterization of platelet membrane-derived nanodiscs (PLT-NDs) as platelet decoys for biological neutralization. These nanodiscs effectively bind with anti-platelet autoantibodies, preventing them from interacting with platelets. In mouse models, PLT-NDs successfully neutralize pathological anti-platelet antibodies and bacterial virulence factors, leading to significant survival benefits. The study highlights the potential of PLT-NDs as a promising platelet mimicry for neutralizing various biological agents that target platelets. [Extracted from the article]

This article discusses a study on serum amyloid A (SAA), a protein that plays a role in inflammation and is used as a biomarker for inflammation. The study aimed to understand the structure of SAA and its interaction with lipids. The researchers used various techniques to characterize the lipid-free and lipid-bound forms of SAA and found that SAA forms octamers that can scaffold lipid nanodiscs. This study provides new insights into the interaction between SAA and lipids and suggests a potential role for SAA in stabilizing protein-lipid nanodiscs during inflammation. [Extracted from the article]

A recent report from Brigham and Women's Hospital in Boston, Massachusetts discusses the potential of nanodiscs in drug delivery and structural biology. Nanodiscs are biocompatible HDL particles that have advantages such as small size, extended circulation time, stability, tolerability, and tissue targeting properties. However, there are challenges in their use as drug carriers, including the costly and laborious process of isolation and purification of endogenous HDL. The report also explores the utility of nanodiscs in structural biology, particularly in investigating virus-cell interactions and characterizing membrane proteins. The researchers evaluate the potential for clinical translation and future applications of nanodiscs. [Extracted from the article]

Researchers from Western Washington University have conducted a study on the thermodynamics and binding orientation of factor VIII (fVIII) membrane association. They found that the C1 domain lipid binding is driven by enthalpic interactions, while the C2 domain binding is driven by entropic interactions. The study also utilized molecular dynamics simulations to identify novel residues that interact with the membrane. This research provides valuable insights into the understanding of fVIII membrane association and could have implications for the development of treatments for blood coagulation disorders. [Extracted from the article]

A recent report from the University of Hafr Al Batin presents research on the use of nanodisk-shaped zinc oxide nanostructures (NDs-ZnONSs) in the treatment of breast cancer. The study found that higher concentrations of NDs-ZnONSs inhibited the growth and morphology of breast cancer cells, while lower concentrations did not show any cytotoxicity. Additionally, the research showed that the expression of apoptotic genes was upregulated when NDs-ZnONSs were used. This study provides valuable insights into the potential use of nanotechnology in breast cancer treatment. [Extracted from the article]

Keywords: Emerging Technologies; Membrane Proteins; Nanodiscs; Nanotechnology EN Emerging Technologies Membrane Proteins Nanodiscs Nanotechnology 3450 3450 1 10/30/23 20231103 NES 231103 2023 NOV 3 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Current study results on nanodiscs have been published. Keywords for this news article include: Universite Claude Bernard Lyon 1, Villeurbanne, France, Europe, Nanodiscs, Nanotechnology, Membrane Proteins, Emerging Technologies. [Extracted from the article]

For more information on this research see: Apolipoprotein-mimetic Nanodiscs Reduce Lipid Accumulation and Improve Liver Function In Acid Sphingomyelinase Deficiency. Keywords: Ann Arbor; State:Michigan; United States; North and Central America; Apolipoproteins; Apoproteins; Drugs and Therapies; Emerging Technologies; Gastroenterology; Health and Medicine; Hepatology; Lipoproteins; Liver Diseases and Conditions; Liver Function; Nanodiscs; Nanotechnology; Pharmaceuticals; Proteins EN Ann Arbor State:Michigan United States North and Central America Apolipoproteins Apoproteins Drugs and Therapies Emerging Technologies Gastroenterology Health and Medicine Hepatology Lipoproteins Liver Diseases and Conditions Liver Function Nanodiscs Nanotechnology Pharmaceuticals Proteins 2196 2196 1 10/24/23 20231027 NES 231027 2023 OCT 27 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators discuss new findings in Liver Diseases and Conditions - Liver Function. [Extracted from the article]

Finally, they transferred the wavelength-tuned microdisk arrays onto a polydimethylsiloxane substrate, producing free-standing, isolated laser particles with distinct lasing wavelengths. Keywords: Biotechnology; Emerging Technologies; Nanodiscs; Nanophotonics; Nanotechnology; Photoelectrochemicals; Photonics; Physics; SPIE--International Society for Optics and Photonics EN Biotechnology Emerging Technologies Nanodiscs Nanophotonics Nanotechnology Photoelectrochemicals Photonics Physics SPIE--International Society for Optics and Photonics 247 247 1 09/19/23 20230921 NES 230921 2023 SEP 21 (NewsRx) -- By a News Reporter-Staff News Editor at Blood Weekly -- Micro- and nanodisk lasers have recently emerged as promising optical sources and probes for various applications in the fields of nanophotonics and biomedicine. With their ultranarrow bandwidth emission, these lasers can potentially revolutionize biosensing performed using well-established biomedical and optical techniques, such as cell dynamics imaging, flow cytometry, and multi-omics analyses. [Extracted from the article]

Keywords: Swarthmore; State:Pennsylvania; United States; North and Central America; Biotechnology; Emerging Technologies; Health and Medicine; Influenza; Liposomes; Membrane Proteins; Nanodiscs; Nanotechnology EN Swarthmore State:Pennsylvania United States North and Central America Biotechnology Emerging Technologies Health and Medicine Influenza Liposomes Membrane Proteins Nanodiscs Nanotechnology 1445 1445 1 08/28/23 20230901 NES 230901 2023 SEP 1 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- New research on Biotechnology - Liposomes is the subject of a report. Electron paramagnetic spectroscopy of spin-labeled AM2 showed that the conformation and dynamics were strikingly similar in both AM2-nanodiscs and AM2-liposomes consistent with similar conformations in both model membranes. [Extracted from the article]

Keywords: Cyclic Nucleotide Research; Emerging Technologies; Genetics; Health and Medicine; Nanodiscs; Nanotechnology EN Cyclic Nucleotide Research Emerging Technologies Genetics Health and Medicine Nanodiscs Nanotechnology 6519 6519 1 08/07/23 20230811 NES 230811 2023 AUG 11 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Research findings on nanodiscs are discussed in a new report. Cyclic Nucleotide Research, Emerging Technologies, Genetics, Health and Medicine, Nanotechnology, Nanodiscs Here, we report structures of the cGMP-activated human cone photoreceptor CNGA3/CNGB3 channel in closed, intermediate, pre-open and open states in detergent or lipid nanodisc, all with fully bound cGMP. [Extracted from the article]

According to the news editors, the research concluded: "Also, the environmentally friendly and direct-contact photocurrent-direction-switching PEC biosensor has an application prospect for cancer biomarker detection." For more information on this research see: A Direct-contact Photocurrent-direction-switching Biosensing Platform Based On In Situ Formation of Cn Qds/tio2 Nanodiscs and Double-supported 3d Dna Walking Amplification. [Extracted from the article]

Keywords: Ann Arbor; State:Michigan; United States; North and Central America; Drugs and Therapies; Emerging Technologies; Health and Medicine; Inulin Therapy; Nanodiscs; Nanotechnology; Pharmaceuticals EN Ann Arbor State:Michigan United States North and Central America Drugs and Therapies Emerging Technologies Health and Medicine Inulin Therapy Nanodiscs Nanotechnology Pharmaceuticals 627 627 1 07/03/23 20230707 NES 230707 2023 JUL 7 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Researchers detail new data in Nanotechnology - Nanodiscs. The news reporters obtained a quote from the research from the University of Michigan, "While the lipid exchange and size flexibil-ity properties of the self-assembled polymer-based nanodiscs are valuable for various applications, the non-ionic polymer nanodiscs are remarkably unique in that they enable the reconstitution of any protein, protein-protein complexes, or drugs irrespective of their charge. [Extracted from the article]

Live cell imaging of NINJ1-deficient THP-1 cells reconstituted with NINJ1-eGFP uncovers the pinching off of NINJ1 rings from the cell surface and the loss of NINJ1 to the culture supernatant in oligomerized forms upon inflammasome activation. While NINJ1 and NINJ2 both formed ring-like structures when mixed with liposomes, strikingly, only NINJ1, but not NINJ2, ruptures liposome membranes, leading to their dissolution. [Extracted from the article]

Keywords: Moscow Region; Russia; Adenosine Therapy; Antiarrhythmic Agents; Cardiac Stressing Agents; Cardiovascular Agents; Drugs and Therapies; Emerging Technologies; Health and Medicine; Nanodiscs; Nanotechnology; Pharmaceuticals; Radiologic Adjuncts; Radiologic Agents EN Moscow Region Russia Adenosine Therapy Antiarrhythmic Agents Cardiac Stressing Agents Cardiovascular Agents Drugs and Therapies Emerging Technologies Health and Medicine Nanodiscs Nanotechnology Pharmaceuticals Radiologic Adjuncts Radiologic Agents 2010 2010 1 05/15/23 20230519 NES 230519 2023 MAY 19 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on Nanotechnology - Nanodiscs. Moscow Region, Russia, Adenosine Therapy, Antiarrhythmic Agents, Cardiac Stressing Agents, Cardiovascular Agents, Drugs and Therapies, Emerging Technologies, Health and Medicine, Nanodiscs, Nanotechnology, Pharmaceuticals, Radiologic Adjuncts, Radiologic Agents. [Extracted from the article]

Palermo, Italy, Europe, Boron, Chemicals, Emerging Technologies, Nanodiscs, Boron Oxide, Nanoparticles, Nanotechnology Keywords for this news article include: Palermo, Italy, Europe, Boron, Boron Oxide, Chemicals, Emerging Technologies, Nanodiscs, Nanoparticles, Nanotechnology, University of Palermo. Keywords: Palermo; Italy; Europe; Boron; Boron Oxide; Chemicals; Emerging Technologies; Nanodiscs; Nanoparticles; Nanotechnology EN Palermo Italy Europe Boron Boron Oxide Chemicals Emerging Technologies Nanodiscs Nanoparticles Nanotechnology 1254 1254 1 05/15/23 20230519 NES 230519 2023 MAY 19 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Data detailed on Nanotechnology - Nanodiscs have been presented. [Extracted from the article]

Although they have previously been mostly made of synthetic lipids and proteins, a research team has now introduced nanodiscs based on the cell membranes of human red blood cells. Keywords: Antibodies; Antitoxins; Bioengineering; Biomimetics; Bionanotechnology; Biotechnology; Blood Cells; Blood Proteins; Cell Research; Drugs and Therapies; Emerging Technologies; Immune Sera; Immunoglobulins; Immunology; Immunoproteins; Nanobiotechnology; Nanodiscs; Nanotechnology; Proteins; Serum Globulins; Wiley EN Antibodies Antitoxins Bioengineering Biomimetics Bionanotechnology Biotechnology Blood Cells Blood Proteins Cell Research Drugs and Therapies Emerging Technologies Immune Sera Immunoglobulins Immunology Immunoproteins Nanobiotechnology Nanodiscs Nanotechnology Proteins Serum Globulins Wiley 972 972 1 04/10/23 20230414 NES 230414 2023 APR 14 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Tiny, disc-shaped pieces of membrane called nanodiscs offer exciting possibilities for nanomedicine. Keywords for this news article include: Antibodies, Antitoxins, Wiley, Nanodiscs, Immunology, Biomimetics, Blood Cells, Immune Sera, Cell Research, Bioengineering, Blood Proteins, Immunoproteins, Immunoglobulins, Serum Globulins, Bionanotechnology, Nanobiotechnology, Drugs and Therapies, Emerging Technologies. [Extracted from the article]

The news reporters obtained a quote from the research from the Huazhong University of Science and Technology, "However, to date, the role of KDM6B in bone marrow-derived macrophages (BMDMs) remains controversial. Keywords: Wuhan; People's Republic of China; Asia; Bone Research; Emerging Technologies; Health and Medicine; Nanodiscs; Nanotechnology; Stem Cell Research EN Wuhan People's Republic of China Asia Bone Research Emerging Technologies Health and Medicine Nanodiscs Nanotechnology Stem Cell Research 116 116 1 03/23/23 20230323 NES 230323 2023 MAR 20 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- Investigators publish new report on Nanotechnology - Nanodiscs. [Extracted from the article]

A DNA-origami template provides a way to control the shapes, sizes, and arrangements of lipid bilayers via enforcing the assembly of lipid bilayers within the cavities created by DNA nanostructures. Keywords: Emerging Technologies; Nanodiscs; Nanostructural; Nanostructures; Nanotechnology EN Emerging Technologies Nanodiscs Nanostructural Nanostructures Nanotechnology 106 106 1 03/24/23 20230224 NES 230224 2023 FEB 24 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Current study results on nanostructures have been published. [Extracted from the article]

Keywords for this news article include: Los Alamos National Laboratory, Los Alamos, New Mexico, United States, North and Central America, Nanodiscs, Nanotechnology, Emerging Technologies. Keywords: Emerging Technologies; Nanodiscs; Nanotechnology EN Emerging Technologies Nanodiscs Nanotechnology 994 994 1 03/24/23 20230217 NES 230217 2023 FEB 17 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- New study results on nanodiscs have been published. We demonstrate that additional considerations may be necessary for the membrane scaffold protein in dimyristoyl-phosphocholine nanodiscs through ultraviolet absorption spectroscopy of nanodiscs, liposomes, the membrane scaffold protein, and a mixture of liposomes and the non-nanodisc-associated protein. [Extracted from the article]