1. C 60 adduct with L-arginine as a promising nanomaterial for treating cerebral ischemic stroke.
- Author
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Kukaliia ON, Ageev SV, Petrov AV, Kirik OV, Korzhevskii DE, Meshcheriakov AA, Jakovleva AA, Poliakova LS, Novikova TA, Kolpakova ME, Vlasov TD, Molchanov OE, Maistrenko DN, Murin IV, Sharoyko VV, and Semenov KN
- Subjects
- Humans, Antioxidants pharmacology, Antioxidants therapeutic use, Water, Ischemia, Arginine therapeutic use, Fullerenes pharmacology, Fullerenes therapeutic use, Fullerenes chemistry, Ischemic Stroke, Nanostructures, Stroke drug therapy
- Abstract
The work aimed to investigate the biocompatibility and biological activity of the water-soluble fullerene adduct C
60 -Arg. It was found that the material is haemocompatible, is not cyto- and genotoxic, possesses pronounced antioxidant activity. Additionally, this paper outlines the direction of application of water-soluble fullerene adducts in the creation of neuroprotectors. It has been suggested that a putative mechanism of the protective action of the C60 -Arg adduct is associated with its antioxidant properties, the ability to penetrate the blood-brain barrier, and release nitrogen monoxide as a result of the catabolism of L-arginine residues, which promote vascular relaxation. The action of the C60 -Arg adduct was compared with the action of such an antioxidant as Edaravone, which is approved in Japan for the treatment of ischemic and haemorrhagic strokes., Competing Interests: Declaration of competing interest There are no conflicts to declare., (Copyright © 2023. Published by Elsevier Inc.)- Published
- 2023
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