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C 60 adduct with L-arginine as a promising nanomaterial for treating cerebral ischemic stroke.
- Source :
-
Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2023 Sep; Vol. 53, pp. 102698. Date of Electronic Publication: 2023 Jul 26. - Publication Year :
- 2023
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Abstract
- The work aimed to investigate the biocompatibility and biological activity of the water-soluble fullerene adduct C <subscript>60</subscript> -Arg. It was found that the material is haemocompatible, is not cyto- and genotoxic, possesses pronounced antioxidant activity. Additionally, this paper outlines the direction of application of water-soluble fullerene adducts in the creation of neuroprotectors. It has been suggested that a putative mechanism of the protective action of the C <subscript>60</subscript> -Arg adduct is associated with its antioxidant properties, the ability to penetrate the blood-brain barrier, and release nitrogen monoxide as a result of the catabolism of L-arginine residues, which promote vascular relaxation. The action of the C <subscript>60</subscript> -Arg adduct was compared with the action of such an antioxidant as Edaravone, which is approved in Japan for the treatment of ischemic and haemorrhagic strokes.<br />Competing Interests: Declaration of competing interest There are no conflicts to declare.<br /> (Copyright © 2023. Published by Elsevier Inc.)
Details
- Language :
- English
- ISSN :
- 1549-9642
- Volume :
- 53
- Database :
- MEDLINE
- Journal :
- Nanomedicine : nanotechnology, biology, and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 37507062
- Full Text :
- https://doi.org/10.1016/j.nano.2023.102698