Back to Search
Start Over
Reduction and functionalization of graphene oxide with L-cysteine: Synthesis, characterization and biocompatibility.
- Source :
-
Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2020 Oct; Vol. 29, pp. 102284. Date of Electronic Publication: 2020 Aug 08. - Publication Year :
- 2020
-
Abstract
- This article presents data on the synthesis, identification, computer simulation and biocompatibility of graphene oxide (GO) functionalized with L-cysteine (GFC). It was determined that GO reacts with L-cysteine in two different ways: in an alkaline medium, L-cysteine reduces functional groups on the surface and at the boundaries of GO; with heating and the use of thionyl chloride, L-cysteine covalently attaches to GO through carboxylic groups only at the boundaries. The identification of GO, reduced graphene oxide and GFC was performed using various physicochemical methods, including infrared spectroscopy, Raman spectroscopy, X-ray diffraction, X-ray photoelectron spectroscopy, thermogravimetric analysis, scanning electron microscopy and high-resolution transmission electron microscopy. Biocompatibility experiments included erythrocyte hemolysis, platelet aggregation, photodynamic and antiradical activity, binding to human serum albumin, and geno- and cytotoxicity studies. Applying density functional theory and molecular dynamics allowed us to obtain the structural and dynamic characteristics of a GFC-water binary system.<br /> (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Subjects :
- Biocompatible Materials chemical synthesis
Biocompatible Materials pharmacology
Cell Line, Tumor
Cell Survival drug effects
Cysteine chemical synthesis
Cysteine pharmacology
Graphite chemical synthesis
Graphite pharmacology
Humans
Microscopy, Electron, Scanning
Spectrum Analysis, Raman
Sulfur Oxides chemistry
Sulfur Oxides pharmacology
Biocompatible Materials chemistry
Cysteine chemistry
Erythrocytes drug effects
Graphite chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1549-9642
- Volume :
- 29
- Database :
- MEDLINE
- Journal :
- Nanomedicine : nanotechnology, biology, and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 32781136
- Full Text :
- https://doi.org/10.1016/j.nano.2020.102284