Back to Search
Start Over
Biocompatibility and biological activity of C 70 fullerene adduct with L-threonine (C 70 (C 4 H 9 NO 3 ) 2 ).
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 Dec 25; Vol. 636 (Pt 1), pp. 50-56. Date of Electronic Publication: 2022 Oct 19. - Publication Year :
- 2022
-
Abstract
- The aim of this work is to synthesise and study the biocompatibility and biological activity of the C <subscript>70</subscript> fullerene adduct with l-threonine (C <subscript>70</subscript> -Thr). The obtained adduct was identified using a complex of physicochemical methods, namely, <superscript>13</superscript> C NMR spectroscopy, IR spectroscopy, thermogravimetric analysis, electron spectroscopy, elemental analysis, and high-performance liquid chromatography. The study of biocompatibility and biological activity of the C <subscript>70</subscript> -Thr adduct included the study of haemocompatibility (haemolysis, platelet aggregation, plasma coagulation haemostasis, binding to human serum albumin, esterase activity), antiradical activity, cytotoxicity, cell proliferation, and interaction with DNA (determination of the DNA binding constant and genotoxicity).<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2022 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 636
- Issue :
- Pt 1
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 36332482
- Full Text :
- https://doi.org/10.1016/j.bbrc.2022.10.054