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Evaluation of the C 60 biodistribution in mice in a micellar ExtraOx form and in an oil solution.

Authors :
Semenov KN
Ivanova DA
Ageev SV
Petrov AV
Podolsky NE
Volochaeva EM
Fedorova EM
Meshcheriakov AA
Zakharov EE
Murin IV
Sharoyko VV
Source :
Scientific reports [Sci Rep] 2021 Apr 16; Vol. 11 (1), pp. 8362. Date of Electronic Publication: 2021 Apr 16.
Publication Year :
2021

Abstract

The article is devoted to the study of the pharmacokinetics of fullerene C <subscript>60</subscript> in oil and micellar forms, analysis of its content in blood, liver, lungs, kidneys, heart, brain, adrenal glands, thymus, testicles, and spleen. The highest accumulation of C <subscript>60</subscript> was found in the liver and adrenal glands. As a result of the studies carried out, it was shown that the bioavailability of C <subscript>60</subscript> in the micellar form is higher than that in an oil solution.

Details

Language :
English
ISSN :
2045-2322
Volume :
11
Issue :
1
Database :
MEDLINE
Journal :
Scientific reports
Publication Type :
Academic Journal
Accession number :
33863918
Full Text :
https://doi.org/10.1038/s41598-021-87014-3