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2024 OCT 5 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- A new study on Infant and Newborn Diseases and Conditions - Neonatal [...]

2024 OCT 5 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Fresh data on type 2 diabetes are presented in a new report. [...]

2024 OCT 5 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers detail new data in Diabetes Research. According to news reporting from [...]

A study conducted at Copenhagen University Hospital in Denmark focused on the effectiveness of diabetes training for psychiatric health professionals in improving outcomes for individuals with diabetes and psychiatric disorders. The research found that training psychiatric health professionals in diabetes care led to improved knowledge and skills, as well as lower systolic blood pressure levels in individuals receiving intervention. However, there was a lower likelihood of receiving annual assessments of blood pressure and BMI among those in the intervention group. The study was a pragmatic controlled trial conducted in eight psychiatric outpatient clinics in Denmark from August 2018 to June 2019. [Extracted from the article]

Recent research from the University of Texas MD Anderson Cancer Center explores immune cell populations in the hindpaws of healthy and diabetic mice, revealing shifts in multiple immune cell types with metabolic disturbance and disease duration in Type 2 diabetes. The study, funded by various organizations including the NIH National Cancer Institute, highlights the increased susceptibility to pathologies of the distal limb in patients with chronic diabetes. This peer-reviewed research provides new insights into diabetic peripheral neuropathy and foot ulcers, emphasizing the importance of understanding immune disruptions in diabetes. [Extracted from the article]

Researchers at Southern Medical University in Guangdong, China, have identified the role of retinoid X receptor alpha (RXR alpha) in promoting cell senescence and metabolic dysregulation in diabetic kidney disease (DKD). Through experimental validation, they found that inhibiting RXR alpha/mineralocorticoid receptor (MR) signaling could alleviate cell senescence in metabolic disorders. This study sheds light on a novel mechanism for targeting cell senescence and metabolic dysregulation in DKD, providing valuable insights for future research in this area. [Extracted from the article]

Researchers from Wenzhou Medical University in Zhejiang, China, have developed a polyphenol-enhanced wet adhesive hydrogel that combines mechanical activation and reactive oxygen species (ROS) scavenging to accelerate the healing of infected diabetic wounds. The hydrogel, copolymerized with acrylic acid, 1-vinylimidazole, and tannic acid, demonstrated toughness, wet tissue adhesive strength, ROS scavenging performance, inflammatory inhibition, and vascular growth promotion. This innovative approach may offer a new method for effectively treating diabetic wounds and chronic wounds, as outlined in a peer-reviewed study published in the Chemical Engineering Journal. [Extracted from the article]

A recent study conducted at Shanghai University of Traditional Chinese Medicine focused on the effects of berberine on gluconeogenesis in diabetic rats. The research found that berberine inhibited gluconeogenesis by downregulating certain proteins and enhancing NO and cGMP concentrations, activating specific signaling pathways. The study suggests that berberine could be a potential drug candidate for diabetic patients, with its mechanism of action possibly involving the AKT/MAPK/NO/cGMP/PKG pathway. The research has been peer-reviewed and provides valuable insights into diabetes treatment options. [Extracted from the article]

Researchers from Tianjin University have developed a novel composite hydrogel to address the challenging conditions of diabetic wounds, which often suffer from oxygen deficiency, reduced angiogenesis, and increased oxidative stress. This hydrogel, containing polydopamine and a catalytic enzyme mimic, demonstrates antioxidant activity and oxygen generation, accelerating the healing of diabetic wounds in rats. The biomaterial also promotes anti-inflammatory responses, epithelial regeneration, angiogenesis, and collagen deposition, offering potential for treating diabetic wounds effectively. The research has been peer-reviewed and published in the Chemical Engineering Journal. [Extracted from the article]

Researchers at Fuwai Hospital in Beijing, China, conducted a retrospective analysis to explore the relationship between iron metabolism and perioperative myocardial injury (PMI) in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). The study included 744 patients, and findings indicated a nonlinear relationship between transferrin (TRF) and total iron-binding capacity (TIBC) with PMI. The research highlighted a U-shaped relationship, suggesting that as TRF and TIBC levels increase, the risk of PMI initially decreases before rising again. Older patients were found to be more susceptible to variations in iron metabolism. The study was supported by the National Natural Science Foundation of China and has been peer-reviewed. [Extracted from the article]

Researchers from Beijing Technology and Business University conducted a study on the anti-diabetic effects of squash polysaccharide on type 2 diabetic rats. The study identified three polysaccharide fractions from squash, with SPS-F2 showing promising results in reducing body weight gain and glucose levels in the rats. Metabolomics analysis revealed key metabolites associated with energy metabolism, gut microbiota, and inflammation, while surface plasmon resonance showed moderate binding of the fractions to galectin-3 and fibroblast growth factor 2. The research concluded that metabolomics and SPR approaches are valuable tools in understanding the mechanisms behind the anti-diabetic effects of squash polysaccharide. [Extracted from the article]

A study conducted at Southeast University in Nanjing, China, explored the Subcutaneous Lumbar Spine Index (SLSI) as a predictor of early surgical site infection (SSI) after lumbar fusion surgery. The research involved 3615 patients who underwent surgery, with 33 developing early SSI. The study found that SLSI was a better indicator than subcutaneous fat thickness (SFT) in predicting the risk of early SSI after lumbar intervertebral fusion surgery. [Extracted from the article]

A study conducted at Columbia University Medical Center focused on the surgical outcomes and quality of life in patients who underwent C2-sacrum posterior spinal fusion (PSF). The research found that approximately 26% of patients required reoperations after the fusion, with improvements in patient-reported outcomes and activities of daily living observed postoperatively. The study concluded that patients who underwent C2-sacrum PSF had better quality of life compared to individuals with degenerative hip/knee arthritis and similar to those with chronic conditions like diabetes mellitus and hypertension. [Extracted from the article]

A recent report from researchers at JSS College of Pharmacy in Tamil Nadu, India, explores the use of silk-based formulations for diabetic wound healing. The study highlights the benefits of Silk fibroin (SF) and Silk sericin (SS) in promoting tissue regeneration and providing anti-inflammatory, anti-oxidant, and anti-bacterial properties. The research emphasizes the potential of combining SF and SS to enhance therapeutic impact and improve diabetic wound management. This peer-reviewed study aims to advance the standard of care in diabetic wound treatment through innovative approaches. [Extracted from the article]

A research study conducted at Yichang Hospital of Traditional Chinese Medicine in Hubei, People's Republic of China, explored the use of ultrasound and contrast-enhanced ultrasound (CEUS) in evaluating renal function damage and blood flow changes in diabetic nephropathy patients. The study included 124 patients who received Shenkang injection (SKI) treatment or conventional treatment. Results showed that SKI treatment led to significant improvements in renal function indicators, urinary albumin levels, plasma viscosity, and blood flow parameters compared to conventional treatment, suggesting SKI as an effective clinical option for diabetic nephropathy patients. The research has been peer-reviewed and published in the International Journal of Radiation Research. [Extracted from the article]

A recent study conducted at Emory University focused on the sex-based outcomes of subcutaneous implantable cardioverter-defibrillator (S-ICD) procedures. The research found that female patients had a higher rate of pocket-related complications compared to male patients due to differences in chest wall anatomy. Despite similar rates of diabetes and other health factors, women had a significantly higher risk of pocket-related issues post-implantation. The study concluded that women experienced more complications, potentially due to anatomical differences, and that these complications decreased after 2018, particularly in women. [Extracted from the article]

A study conducted at Manipal Academy of Higher Education in Karnataka, India, focused on developing a disposable paper-based thin film solid-phase microextraction sampling kit to quantify ketone bodies for diabetes research. The study aimed to improve the detection of beta-hydroxybutyric acid (BHB) ketone bodies in diabetes ketoacidosis (DKA) by utilizing a cost-effective paper-based patch coupled with gas chromatography-mass spectrometry. The research demonstrated the feasibility of using these paper-based patches as a sampling kit for screening DKA, offering a simpler and more efficient alternative to traditional sample preparation methods. The study was supported by the Research Society for the Study of Diabetes in India and can be further explored in the journal RSC Advances. [Extracted from the article]

A study conducted at the University of Ha'il in Saudi Arabia explores the potential of aldose reductase inhibitors (ARIs) as therapeutic targets for diabetes-related disabilities. Diabetes mellitus is known to increase mortality and morbidity rates due to complications such as neuropathy, nephropathy, retinopathy, and cataract formation. The research highlights the importance of understanding AR's function and structure to develop more effective ARIs for mitigating diabetic complications, although challenges remain in translating preclinical success to clinical effectiveness. Overcoming these challenges could significantly improve patient outcomes and reduce the global burden of diabetes-related mortality and morbidity. [Extracted from the article]

A recent study conducted by researchers at the University of Kentucky focused on analyzing risk factors associated with complications in septorhinoplasty using Polydioxanone (PDS) plates, particularly looking at the impact of smoking and diabetes. The study found that current smoking was significantly associated with increased early complications in patients undergoing septorhinoplasty with PDS plates, while diabetes did not show a significant difference in complication rates. The research concluded that diabetic patients did not have an increased risk of complications. This study provides valuable insights into the factors affecting outcomes in septorhinoplasty procedures. [Extracted from the article]

Researchers from Hungkuang University in Taichung, Taiwan, have found that miR-200b-3p accelerates diabetic wound healing by reducing inflammation and promoting angiogenesis. In a study on diabetic mice, miR-200b-3p was more effective than miR-146a-5p in improving wound healing, with reduced expression of inflammatory genes and increased expression of genes related to tissue repair. This research provides valuable insights into potential treatments for diabetic foot ulcers and highlights the importance of microRNAs in promoting healing. [Extracted from the article]

A recent study conducted by investigators at the Public Health Foundation of India focused on assessing the cost-effectiveness of a multicomponent quality improvement care model for individuals with type 2 diabetes in South Asia. The study involved 1146 participants from urban clinics in India and Pakistan and found that the multicomponent strategy resulted in better multiple risk factor control, albeit at higher costs. The research concluded that future studies should confirm the long-term cost-effectiveness of intensive multifactorial intervention for diabetes care in diverse healthcare settings in low- and middle-income countries. [Extracted from the article]

A recent report from the Department of Internal Medicine discusses the occurrence of euglycemic ketoacidosis associated with SGLT-2 inhibitors in non-diabetic patients. This life-threatening condition is characterized by euglycemia, metabolic acidosis, and ketonemia, and is a known adverse event in diabetic patients using SGLT-2 inhibitors. The study highlights the importance of recognizing the signs and symptoms of this condition, especially as the use of SGLT-2 inhibitors expands beyond diabetes treatment to other conditions like congestive heart failure. The research emphasizes the need to understand the risk factors and pathophysiology of euglycemic ketoacidosis in non-diabetic patients to effectively manage and treat this serious condition. [Extracted from the article]

Researchers at Indiana University have conducted a study on the crosstalk between exocrine and endocrine cells in the pancreas, highlighting the impact of exocrine diseases on endocrine function. The study suggests that communication between these compartments is crucial in understanding pancreatic physiology and disease states, with implications for diabetes development. The research emphasizes the need for further investigation into the mechanisms underlying cellular communication in the pancreas to advance our understanding of pancreatic function and disease progression. [Extracted from the article]

A study conducted at the Beijing Institute of Technology in China focused on developing thermoresponsive self-healing hydrogel dressings for diabetic wound healing. The hydrogel dressings were designed to deliver curcumin and exhibited properties such as thermoresponsive sol-gel irreversibility, efficient self-healing, and pH/glucose responsive drug release. The research aimed to address challenges in treating diabetic wounds by providing a novel strategy for managing chronic diabetic wounds effectively. The study was supported by the Beijing Institute of Technology Soft Materials Research Project and has been peer-reviewed. [Extracted from the article]

A recent study conducted at Qatar University explored the potential anti-diabetic effects of curcumin, a natural polyphenol found in turmeric. The research utilized network pharmacology, molecular docking, and simulation techniques to identify key molecular targets and pathways involved in curcumin's effects on diabetes. The study identified 60 common targets for curcumin in diabetes, highlighting key hub genes and interactions that could serve as potential biomarkers for future advancements in diabetes treatment. This research provides valuable insights into the molecular mechanisms underlying curcumin's anti-diabetic properties, offering a new paradigm for effective diabetes treatment. [Extracted from the article]

Researchers at Kunming Medical University conducted a study on early biliary infection (EBI) following I-125 particle stent implantation in patients with malignant biliary obstruction. The study included 178 patients, of which 19.7% developed EBI within 30 days post-implantation. Risk factors for EBI included diabetes, gallstones, high-level obstruction, intraoperative biliary bleeding, and postoperative intrahepatic pneumobilia, while a longer interval from percutaneous transhepatic biliary drainage to stent implantation was found to be protective. The research aims to guide interventions to reduce biliary infections post-stent implantation and shorten hospital stays for affected patients. [Extracted from the article]

A recent study conducted at the Ulsan National Institute of Science and Technology in South Korea has developed a high-efficiency, prevascularization-free macroencapsulation system for subcutaneous transplantation of pancreatic islets to treat Type I diabetes. This system, which involves a multilayer sheet design, has shown promising results in improving insulin secretion function and stabilizing blood glucose levels in diabetic mice. The research suggests that this macroencapsulation system could advance the treatment of Type I diabetes and potentially be effective for islet xenotransplantation in subcutaneous tissue. [Extracted from the article]

A recent study conducted by researchers at Wake Forest University in Winston-Salem, North Carolina, explores the impact of statin therapy on the incidence of diabetes in primary prevention. The study found that there is a modest, dose-dependent increase in the risk of diabetes from statin therapy. However, this risk is outweighed by the cardiovascular protection offered by statin therapy, and therefore should not deter clinicians from recommending statin initiation in primary prevention. The study concludes that further research is needed to better understand the underlying mechanisms of this relationship. [Extracted from the article]

A recent study conducted at Southmead Hospital in Bristol, United Kingdom, explored the prevalence and content of advance care planning for individuals undergoing lower limb amputation due to peripheral arterial disease or diabetes. The study found that only 40.5% of patients had advance care planning discussions, which primarily focused on resuscitation. The research also revealed that patients who engaged in advance care planning had higher mortality rates and longer hospital stays. The study highlights the need for improved advance care planning for individuals undergoing amputation and suggests that discussions should encompass a broader range of options beyond resuscitation. [Extracted from the article]

A recent study conducted by investigators from the Birla Institute of Technology in Ranchi, India, explores the potential of phenylethanoid glycosides (PhGs) from Clerodendrum glandulosum (CG) for diabetic wound healing. The study utilizes in-silico approaches to identify the potential targets of PhGs and their associated disease IDs. The research concludes that PhGs present in CG have the potential to treat diabetic wounds, but further in-vitro and in-vivo investigations are needed. This study provides valuable insights into the molecular pathways and interactions involved in diabetic wound healing. [Extracted from the article]

A study conducted at the Cleveland Clinic Foundation examined the impact of diabetes and preoperative glycemic control on wound morbidity following open complex abdominal wall reconstruction (AWR). The study included diabetic patients who underwent the procedure and compared their outcomes to non-diabetic patients. The results showed that diabetic patients had higher rates of wound morbidities and overall complications compared to non-diabetic patients. However, there was no significant difference in rates of surgical site infection, surgical site occurrence, and reoperation among the different levels of glycemic control. The researchers concluded that this data is important for shared decision-making when considering AWR for symptomatic ventral hernias in diabetic patients. [Extracted from the article]

A recent study conducted by researchers from Zhejiang University in Hangzhou, China, explored the effects of hyperbranched poly-l-lysine (HBPL) titanium surfaces on osseointegration, bacteriostasis, and anti-inflammation. The study involved three different animal models and found that the HBPL-Ti surfaces demonstrated enhanced osseointegration, bacteriostasis, and anti-inflammatory effects. The surfaces showed improved bone volume, bone-implant contact, and trabecular number in beagles, reduced bleeding and plaque index in an infected model, and increased bone volume and downregulated inflammatory markers in diabetic rats. This research has been peer-reviewed and may have implications for implant applications. [Extracted from the article]

Researchers at Delta University for Science and Technology in Gamasa, Egypt have developed a localized delivery approach for the drug Roxadustat (ROX) to enhance wound healing in diabetic patients. The study focused on chronic non-healing wounds, which are a major complication for individuals with diabetes. The researchers incorporated ROX-loaded cubosomes into a thermosensitive hydrogel, which showed promising results in accelerating wound closure and improving tissue characteristics in diabetic rats. This localized delivery approach holds significant promise as a novel therapeutic strategy for promoting wound healing in clinical settings. [Extracted from the article]

A study conducted by researchers at Tongji University in Shanghai, China has developed a chromium-based magnetic resonance probe for in situ gastric pH imaging. The probe, called Cr(OH)3@HSA, was designed to monitor gastric fluid pH levels in a non-invasive and real-time manner. The researchers found that the probe accurately detected abnormal gastric pH levels and evaluated the efficacy of gastric antiacids. However, they also discovered that chromium picolinate, a common dietary supplement for diabetes, could interfere with the magnetic resonance signal in the gastrointestinal tract, suggesting that diabetic patients should avoid chromium-based supplements prior to MRI procedures. [Extracted from the article]

A report from University Hospital Cleveland discusses the impact of visceral and hepatic fat on cardiometabolic health in relation to diabetes research. The research highlights the significant role that body fat distribution plays in the consequences of obesity, particularly in cardiovascular disease. While the association between hepatic fat and cardiovascular disease is less clear, emerging therapies such as sodium glucose co-transporter-2 (SGLT2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists have shown promise in reducing visceral and hepatic fat and improving cardiometabolic risk. Lifestyle modifications, pharmacologic interventions, and surgical interventions are all potential treatment options. [Extracted from the article]

A recent study conducted by the University of Gothenburg in Sweden examined the progression of HbA1c levels in children and adolescents with type 1 diabetes from 2010 to 2019. The study found that there was a gradual decrease in mean HbA1c levels over the two-year period, reaching levels comparable to recent intervention studies. The researchers also noted a correlation between HbA1c levels at 3 and 6 months with levels at 12, 18, and 24 months. The study suggests that the decrease in HbA1c levels may be attributed to increased use of diabetes technology and a lower HbA1c target. [Extracted from the article]