Researchers at Southern Medical University Target Diabetes Research (Rxra/mr Signaling Promotes Diabetic Kidney Disease By Facilitating Renal Tubular Epithelial Cells Senescence and Metabolic Reprogramming).

Researchers at Southern Medical University in Guangdong, China, have identified the role of retinoid X receptor alpha (RXR alpha) in promoting cell senescence and metabolic dysregulation in diabetic kidney disease (DKD). Through experimental validation, they found that inhibiting RXR alpha/mineralocorticoid receptor (MR) signaling could alleviate cell senescence in metabolic disorders. This study sheds light on a novel mechanism for targeting cell senescence and metabolic dysregulation in DKD, providing valuable insights for future research in this area. [Extracted from the article]