50 results on '"Cynthia M. Shafer"'
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2. Supplementary Figure Legends from Novel Potent and Selective Inhibitors of p90 Ribosomal S6 Kinase Reveal the Heterogeneity of RSK Function in MAPK-Driven Cancers
3. Supplementary Table 2 from Novel Potent and Selective Inhibitors of p90 Ribosomal S6 Kinase Reveal the Heterogeneity of RSK Function in MAPK-Driven Cancers
4. Supplementary Figures 1 - 4 from Novel Potent and Selective Inhibitors of p90 Ribosomal S6 Kinase Reveal the Heterogeneity of RSK Function in MAPK-Driven Cancers
5. Data from Novel Potent and Selective Inhibitors of p90 Ribosomal S6 Kinase Reveal the Heterogeneity of RSK Function in MAPK-Driven Cancers
6. Supplementary Table 1 from Novel Potent and Selective Inhibitors of p90 Ribosomal S6 Kinase Reveal the Heterogeneity of RSK Function in MAPK-Driven Cancers
7. Imidazo[1,2- a ]pyridin-6-yl-benzamide analogs as potent RAF inhibitors
8. Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3
9. Discovery of a Selective and Potent Inhibitor of Mitogen-Activated Protein Kinase-Interacting Kinases 1 and 2 (MNK1/2) Utilizing Structure-Based Drug Design
10. Discovery and optimization of novel pyridines as highly potent and selective glycogen synthase kinase 3 inhibitors
11. Design and synthesis of potent RSK inhibitors
12. Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Orally Bioavailable and Brain Penetrant Mutant IDH1 Inhibitors
13. Discovery of Potent and Selective RSK Inhibitors as Biological Probes
14. Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor
15. 2-Amino-7-substituted benzoxazole analogs as potent RSK2 inhibitors
16. Drug discovery considerations in the development of covalent inhibitors
17. Design and synthesis of 6,6-fused heterocyclic amides as raf kinase inhibitors
18. Design and synthesis of 5,6-fused heterocyclic amides as Raf kinase inhibitors
19. Allyl Silane Additions to Highly Electrophilic 5,6-Dihydro-2H-1,4- oxazinones
20. Design, Structure−Activity Relationships and in Vivo Characterization of 4-Amino-3-benzimidazol-2-ylhydroquinolin-2-ones: A Novel Class of Receptor Tyrosine Kinase Inhibitors
21. Design and Synthesis of Orally Bioavailable Benzimidazoles as Raf Kinase Inhibitors
22. 4-(1H-Indazol-5-yl)-6-phenylpyrimidin-2(1H)-one analogs as potent CDC7 inhibitors
23. 3-Benzimidazol-2-yl-1H-indazoles as potent c-ABL inhibitors
24. LHMDS mediated tandem acylation–cyclization of 2-aminobenzenecarbonitriles with 2-benzymidazol-2-yl acetates: a short and efficient route to the synthesis of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones
25. Discovery of RAF265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma
26. Design, structure-activity relationship, and in vivo characterization of the development candidate NVP-HSP990
27. Design and Synthesis of Orally Bioavailable Benzimidazole Reverse Amides as Pan RAF Kinase Inhibitors
28. Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancers
29. First Total Synthesis of Bengazole A
30. Synthesis of the C1C9 core of bengazole A: Harnessing the ambident nucleophilicity of 2-lithiooxazole
31. Mechanism of SeO2 promoted oxidative rearrangement of 2-substituted oxazolines to dihydrooxazinones: Isotopic labeling and kinetic studies
32. Oxidative Rearrangement of 2-Substituted Oxazolines. A Novel Entry to 5,6-Dihydro-2H-1,4-oxazin-2-ones and Morpholin-2-ones
33. 3D Pharmacophore Model-Assisted Discovery of Novel CDC7 Inhibitors
34. ChemInform Abstract: Oxidative Rearrangement of 2-Substituted Oxazolines. A Novel Entry to 5,6-Dihydro-2H-1,4-oxazin-2-ones and Morpholin-2-ones
35. ChemInform Abstract: Practical Synthesis of 2,6-Dideoxy-D-lyxo-hexose (′′2-Deoxy-D-fucose′′) from D-Galactose
36. ChemInform Abstract: First Total Synthesis of Bengazole A
37. ChemInform Abstract: A Practical Synthesis of 1,3-Oxazole
38. ChemInform Abstract: Allyl Silane Additions to Highly Electrophilic 5,6-Diyhdro-2H-1,4-oxazinones
39. Synthesis and structure-activity relationships of bengazole A analogs
40. Inhibition of Cdc7/Dbf4 kinase activity affects specific phosphorylation sites on MCM2 in cancer cells
41. Design and Structure—Activity Relationship of Heterocyclic Analogues of 4-Amino-3-benzimidazol-2-ylhydroquinolin-2-ones as Inhibitors of Receptors Tyrosine Kinases
42. Design and structure-activity relationship of 3-benzimidazol-2-yl-1H-indazoles as inhibitors of receptor tyrosine kinases
43. Correction to Design and Synthesis of Orally Bioavailable Benzimidazole Reverse Amides as Pan RAF Kinase Inhibitors
44. Design and structure-activity relationship of heterocyclic analogs of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones as inhibitors of receptor tyrosine kinases
45. Monosubstituted Oxazoles. 1. Synthesis of 5-Substituted Oxazoles by Directed Alkylation
46. First synthesis of bengazole A
47. Practical synthesis of 2,6-dideoxy-D-lyxo-hexose ('2-deoxy-D-fucose') from D-galactose
48. Corrigendum to 'Synthesis and structure–activity relationships of bengazole A analogs' [Bioorg. Med. Chem. Lett. 19 (2009) 2928]
49. A Practical Synthesis of 1,3-Oxazole
50. Design and Synthesis of Orally Bioavailable Benzimidazoles as Raf Kinase Inhibitors.
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