Back to Search
Start Over
Design and Synthesis of Orally Bioavailable Benzimidazoles as Raf Kinase Inhibitors
- Source :
- Journal of Medicinal Chemistry. 51:7049-7052
- Publication Year :
- 2008
- Publisher :
- American Chemical Society (ACS), 2008.
-
Abstract
- A series of arylaminobenzimidazoles was designed and synthesized as Raf kinase inhibitors. Exploration of the structure-activity relationship resulted in compounds that are potent in vitro and show desirable in vivo properties.
- Subjects :
- Models, Molecular
Administration, Oral
Biological Availability
Crystallography, X-Ray
Chemical synthesis
Mice
Structure-Activity Relationship
In vivo
Cell Line, Tumor
Drug Discovery
Animals
Humans
Structure–activity relationship
Cytotoxicity
Protein Kinase Inhibitors
Cell Proliferation
chemistry.chemical_classification
Dose-Response Relationship, Drug
Molecular Structure
biology
Chemistry
Stereoisomerism
Xenograft Model Antitumor Assays
In vitro
Protein Structure, Tertiary
Enzyme
Biochemistry
Enzyme inhibitor
Drug Design
Mitogen-activated protein kinase
biology.protein
Molecular Medicine
Benzimidazoles
Female
raf Kinases
Subjects
Details
- ISSN :
- 15204804 and 00222623
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Journal of Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....eac8364ed63d780ab22bc8612199bc9a