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Design and Synthesis of Orally Bioavailable Benzimidazole Reverse Amides as Pan RAF Kinase Inhibitors
- Source :
- ACS medicinal chemistry letters. 5(9)
- Publication Year :
- 2014
-
Abstract
- Benzimidazole reverse amides were designed and synthesized as Pan RAF kinase inhibitors. Investigation of the structure–activity relationship of the compounds revealed that they were potent in vitro and exhibited desirable in vivo properties.
Details
- ISSN :
- 19485875
- Volume :
- 5
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- ACS medicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....631da30643ffa236aa0d6a9d30aec126