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Design and structure-activity relationship of 3-benzimidazol-2-yl-1H-indazoles as inhibitors of receptor tyrosine kinases
- Source :
- Bioorganicmedicinal chemistry letters. 16(13)
- Publication Year :
- 2006
-
Abstract
- 3-Benzimidazol-2-yl-1H-indazole analogs were developed as inhibitors of receptor tyrosine kinases (RTK). The synthesis and SAR of this series is reported.
- Subjects :
- Models, Molecular
Indazoles
Stereochemistry
Clinical Biochemistry
Receptor Protein-Tyrosine Kinases
Pharmaceutical Science
Mice, Nude
RTK class III
Crystallography, X-Ray
Biochemistry
Tropomyosin receptor kinase C
Receptor tyrosine kinase
Mice
Structure-Activity Relationship
Cell Line, Tumor
Drug Discovery
Structure–activity relationship
Animals
skin and connective tissue diseases
Molecular Biology
Cell Proliferation
biology
Dose-Response Relationship, Drug
Molecular Structure
Chemistry
fungi
Organic Chemistry
Stereoisomerism
body regions
Drug Design
ROR1
biology.protein
Molecular Medicine
Benzimidazoles
Tyrosine kinase
Proto-oncogene tyrosine-protein kinase Src
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 16
- Issue :
- 13
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....3f89cec437c69fff8a427e4420d7d12e