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Design and synthesis of 5,6-fused heterocyclic amides as Raf kinase inhibitors
- Source :
- Bioorganic & Medicinal Chemistry Letters. 21:3286-3289
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- Two scaffolds based on 5,6-fused heterocyclic backbones were designed and synthesized as Raf kinase inhibitors. The scaffolds were assessed for in vitro pan-Raf inhibition, activity in cell proliferation and target modulation assays, and pharmacokinetic parameters.
- Subjects :
- Models, Molecular
Binding Sites
Molecular Structure
Chemistry
Stereochemistry
Organic Chemistry
Clinical Biochemistry
Pharmaceutical Science
Raf kinase
Amides
Biochemistry
In vitro
Enzyme Activation
Structure-Activity Relationship
Heterocyclic Compounds
Drug Design
Drug Discovery
Molecular Medicine
raf Kinases
Enzyme Inhibitors
Molecular Biology
Cell Proliferation
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....547fbcd3db3efa6a58bf107e5a7a92d3
- Full Text :
- https://doi.org/10.1016/j.bmcl.2011.04.023