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Objective To investigate the effect and potential mechanism of early exercise intervention on cerebral myelin in cerebral ischemia rats. Methods A total of 18 SD rats were randomly divided into the sham group, the middle cerebral artery occlusion resting group (MCAO-SED) and the middle cerebral artery occlusion exercise group (MCAO-EX), with 6 rats in each group. Except the sham group, the middle cerebral artery occlusion model was prepared by modified Longa line embolization method in other groups. After modeling, rats in the MCAO-EX group were placed on a treadmill for exercise intervention for 28 days. Neurological function was assessed by modified neural function deficit score (mNSS). Infarct volume was detected by MRI scanning (T2), myelin basic protein (MBP) expression was detected by immunofluorescence. Myelin sheath structure was detected by transmission electron microscopy. Western blot assay was used to detect endoplasmic reticulum stress-related protein expression. Apoptosis was detected by TUNEL staining. Results After 28 days of intervention, compared with the MCAO-SED group, the nerve function recovered well in the MCAO-EX group, infarct volume decreased, myelin integrity increased, MBP fluorescence intensity expression increased and MBP expression level increased. The expression levels of ATF6, p-IRE1, p-PERK and cleaved caspase 3 were significantly decreased, and apoptosis was reduced. Conclusion Early exercise can inhibit endoplasmic reticulum stress-induced apoptosis, promote cerebral myelin repair, reduce infarct size and improve nerve function. [ABSTRACT FROM AUTHOR]

Nanxun Bridge is a self-anchored suspension bridge with double towers and double cables. It spans the class III waterway of Changhushen with a span of (3+45+100+45+3) m. In order to eliminate the construction risk of temporary ground anchors of self-anchored suspension bridges in soft foundations, the segmental installation of steel girders by cable cranes is optimized to the large segmental installation of steel girders by less support method, and temporary anchoring and temporary cable strands are eliminated. The girder before cable technology is adopted, the horizontal force of the main cable is balanced by the axial horizontal force of the longitudinal steel girder of the main span, and the cable, end cross beam and longitudinal steel box girder are self -stabilized by the stress system. The construction procedure of the main cable erection and derrick tension is simple, and the cable strands are accurate, which improves the installation accuracy of the cable system, saves the engineering cost of temporary anchorage and temporary cable strands, and shortens the construction period. [ABSTRACT FROM AUTHOR]

In order to explore the microscopic mechanism of heavy metals migration in ice water medium of Lake Ulansuhai, indoor unidirectional icing simulation was carried out on water samples of different heavy metals (Fe、As、Cr、Cu、Zn、Mn、Cd、Hg、Pb) in Lake Ulansuhai during the icebound period, and the distribution characteristics of substances in the ice layer and sub ice water layer were summarized. The calculation was carried out according to the first principle, and its microscopic mechanism was analyzed from the perspective of binding energy. The binding energy of heavy metals with water is greater than the binding energy of heavy metals with ice. A large binding energy means that heavy metals are more stable in water. That is to say heavy metals are more stable in water than in ice, driving them to migrate from ice layer to sub ice water layer. [ABSTRACT FROM AUTHOR]

Using titanium tetrachloride as the raw material, TiCl4 was prepared into a 0.5mol/L aqueous solution in an ice water bath under weakly alkaline conditions. The precipitate was obtained by low-temperature hydrolysis, and the precipitate was dried in a vacuum oven at 80 °C and roasted at low temperature of 400 °C for 12 hours to obtain white powder. Structural characterization was carried out through X-ray diffraction (XRD). The morphology was characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The obtained sintered products were combined with metal lithium electrode materials and polyethylene separators to construct a semi battery system for battery performance testing. The results showed that titanium tetrachloride was used as the raw material to achieve slow hydrolysis under low temperature conditions, and then subjected to long-term low-temperature calcination to obtain a white powder of nanoscale rutile type TiO2, which has advantages such as small particle size, good dispersibility, narrow particle size distribution, and good sphericity. This product has a first discharge specific capacity of 169 mAh/g at 0.2 charge and discharge, and a discharge specific capacity of 69 mAh/g at 5 C, with a capacity retention rate of 91.69%, respectively. Its electrochemical performance is much higher than that of commercial TO2. Research has shown that the method of preparing TiO2, based on slow hydrolysis low-temperature sintering mechanism is a simple, low-cost, and suitable process for large-scale production. [ABSTRACT FROM AUTHOR]

MgCl2/2-Ethylhexanol/TiCl4system was used to synthesize spherical Ziegler-Natta catalyst for ethylene polymerization, and the composite internal electron donor was added in the synthesis process:nhexyl acetate/diisobutyl phthalate was compared with tetraethoxysilane, ethyl acetate and diisobutyl phthalate as electron donors, respectively.The catalysts and polymers containing different internal electron donors were analyzed by means of X-ray diffraction (XRD), scanning electron microscopy (SEM) and differential scanning calorimetry (DSC), and the catalytic performance of the catalysts was evaluated by ethylene polymerization.The results showed that under the conditions of temperature 80℃, pressure0.5 MPa and time 2 h, the catalytic activity of the catalyst containing complex internal electron donornhexyl acetate/diisobutyl phthalate was higher than that of other single internal electron donor catalysts, and the catalytic activity was 1.24×105g PE/(molTi·h). [ABSTRACT FROM AUTHOR]

Predicting and controlling uneven settlement is a key problem to be solved in subgrade widening engineering. In view of the different treatment processes and load processes of the new and old subgrade, finite element analysis and other methods were used to explore the appropriate new subgrade treatment process, the joint stress and mutual influence mechanism of the new and old subgrade, predict the settlement during the construction period and after construction, propose the un even settlement control scheme, and successfully apply it to the reconstruction and expansion project of Hudi Avenue. The experience can be used for reference in the implementation of similar projects. [ABSTRACT FROM AUTHOR]

The finite-time guaranteed cost control problem is studied for impulsive stochastic Markov jump systems with time-varying delays. By selecting mode-dependent Lyapunov functionals, using techniques such as Linear Matrix Inequality (LMI) and average dwell time, we obtain some new sufficient conditions to ensure finite-time stability and the upper bound performance index of the system, hence design a guaranteed cost controller with state feedback. Finally, the LMI toolbox of Matlab is used for data simulation, and the corresponding mean-square trajectory plots are obtained. Numerical examples show that the obtained simulation results are consistent with the theoretical results, which verifies the effectiveness of the proposed approach. [ABSTRACT FROM AUTHOR]

A total of 36 gold-silver ore bodies have been delineated in the Jihua medium-scale shallow medium- low temperature hydrothermal gold - silver deposit, all of which occur in the NE fault structural alteration zone. Silver physical phase analysis shows that silver is mainly composed of silver sulfide and native silver. Silver and gold are generally coexisting in the same body, and both grades are positively correlated. The mineral assemblage of the main mineralization stage is characterized by quartz - pyrite chalcopyrite-gold-silverite. 4 alteration zones were divided along the horizontal (lateral) direction of the ore body. In order to determine the material migration during hydrothermal alteration, the standardized Isocon diagram method was used to calculate the material migration characteristics of altered fractured rocks. The results showed that Fe, Si, Mg, Ti, Cu, As, Mo, Co, Cr, La, Li, Ni, and V showed immigration characteristics during the alteration process; Na, Ca, Ba, Sr, and Nb migrated out. The emigration of Ca, Ba, and Sr indicates the characteristics of silicon-rich and decalcified ore-forming hydrothermal fluids; by analogy with the previous research results of Qiucun Gold Deposit, Dongyang Gold Deposit, and Dadongkeng Gold Deposit in the same area, the 4 deposits are all formed by the gold and silver metallogenic system in central Fujian. They may be the regional metallogenic model of the subduction and retreat of the ancient Pacific plate, the migration of ore-bearing fluid along the volcanic mechanism, and acid dike channel to the shallow fault zone to precipitate mineralization. The research can provide ideas for the search for gold - silver deposits in the region. [ABSTRACT FROM AUTHOR]

慢性阻塞性肺疾病(COPD)是以不可逆气流受限为特征的呼吸系统慢性气道炎症性疾病, 发掘可靠的生 物标志物是 COPD 早期诊断并及时干预的重要手段. 目前 COPD 的诊断主要依赖于病史采集和肺功能检测, 临床 上尚缺乏敏感度和特异度较高的早期生物标志物以辅助诊断. 组学技术是-种将高通量技术应用于生命科学研究 的方法, 包括代谢组学、蛋白质组学、转录组学等多个方面的技术, 可对生物体各阶段的代谢产物、蛋白质和基因表 达情况进行研究. 近年来, 组学技术的发展和应用为COPD的诊断带来了新思路, 通过组学技术对COPD发生发展 动态变化过程的探索, 可为COPD的诊断及鉴别提供支持. [ABSTRACT FROM AUTHOR]

Using the vertical pipe test data of riverbed sediment in the downstream section of the main stream of Hotan River, the paper carried out the application and evaluation of different vertical pipe test parameter calculation methods. The HTST01 test point was selected for vertical permeability test, and the HTST02 test point was selected for horizontal and vertical permeability tests, respectively. The rationality of the permeability coefficient value obtained by the traditional calculation method and the difference between its calculation results and the linear graphical method were analyzed. The results indicate that: the array of permeability coefficients obtained by traditional calculation methods approximately follows a non-standard normal distribution with certain skewness and kurtosis, all of which have moderate variability. The use of arithmetic mean values for parameter values has certain rationality and applicability. When using random calculation values, the error size of parameter values has contingency and uncertainty. The straight line graphical method can effectively avoid the generation of random errors, but the calculation results obtained by it differ from the arithmetic mean of traditional calculation methods to some extent. The average relative error value is 10.59%, and the maximum relative error value exceeds 27.00%. In the application process of vertical pipe tests, the influence of the rationality of parameter values obtained by calculation methods should not be ignored. [ABSTRACT FROM AUTHOR]

目的：调查医养结合机构内老年人辅助器具使用现状及其影响因素, 为老年人辅助器具服务体系建立与健全提供参 考依据。方法：采用方便抽样法, 运用医养结合机构老年人辅助器具使用与需求现状调查问卷调查重庆市17家医养结合机 构2653名老年人, 采用Logistic回归进行影响因素分析。结果：医养结合机构老年人辅助器具使用率为74.44%、需求率为83.79%、满意率为29.42%。矫形器和假肢类辅助 器具使用率与需求率最高, 就业和职业培训辅助器具最低；Logistic回归分析显示, 性别、文化程度、年龄、经济收入、残疾人证情况、慢性病数量、肢体功能障碍、视觉功能障碍、听觉功能障碍、认知功能、日常生活活动能力等是老年人 辅助器具使用的影响因素。结论：医养结合机构老年人辅助器具使用人数多、需求高、影响因素复杂且满意度低, 应推进各部门辅助器具服务网 络资源整合, 推动职业化体系建设, 加大人才培养力度, 促进辅助器具知识宣传与普及落地化, 加大辅助器具产品创 新与研发力度, 健全辅助器具服务体系。 [ABSTRACT FROM AUTHOR]

To explore the correlation between comorbidities of chronic non-communicable diseases (chronic diseases), phase angle (PhA), and muscle mass decline associated with sarcopenia in the elderly, and the predictive value of chronic discuse comorbidities and PhA in muscle mass decline in the elderly. Methods By retrospectively screening inpatients aged 60 years who were admitted to the Department of Geriatrics, Renji Hospital, Shanghai Jiao Tong University School of Medicine from August 1, 2018 to July 31, 2019, basic information and medical history of the patients (gender, age, number of medications used, number of comorbidities, presence of osteoporosis, smoking history, etc.) were collected, as well as laboratory examination indicators (hemoglobin, albumin, serum creatinine, serum uric acid, ferritin, vitamin D, triacylglycerol, total cholesterol, high-density lipoprotein, low-density lipoprotein, etc.). The age-adjusted Charlson comorbidity index (aCCI) was calculated. The InBody 510 bioelectrical impedance body composition detector was used to test the body composition. Body mass index (BMI), skeletal muscle mass index (SMI), and PhA were collected. Some patients underwent measurement of grip strength. Muscle mass decline was diagnosed by using the SMI values recommended by the 2019 Asian Working Group for Sarcopenia (AWGS) (€7.0 kg/m² for males and 65,7 kg/m for females). According to the measured SMI values, patients were divided into a group with normal muscle mass and a group with muscle mass decline. Univariate and multivariate Logistic analyses were employed to investigate the risk factors associated with muscle mass decline related to sarcopenia in the elderly. Additionally, the receiver operator characteristic (ROC) curve and the area under the curve were utilized to predict the significance of these factors in muscle mass decline. Results A total of 359 chronic disease patients were enrolled, including 226 males and 133 females. There were 241 cases in the normal muscle mass group and 118 cases in the muscle mass decline group. The incidence of muscle mass decline related to sarcopenia in the elderly was 32.9%. The univariate Logistic regression analysis showed thuat age (OR-1.036, 95%CI 1.013-1.060), comorbidities (OR-1.117, 95%(71.025-1217), aCCI (OR-1.123, 95%C7 1.031-1.222), and high-density lipoprotein (OR-3.688, 95%CI 2.065-6.622) were positively correlated with the risk of muscle mass decline in the elderly. BMI (OR-0.514, 95%CI 0.443-0.597), PhA (OR-0.195. 95%C70.126-0303), hemoglobin (OR-0.984, 95%CI 0.972-11.996) and triacylglycerol (OR-0.606, 95%CI 0.424-0.866) were negatively correlated with the risk of muscle mass decline in the elderly. Multivariate Logistic regression model indicated that PhA (OR-0.338, 95%CI 0.119-0.959) and HMI (OR-0,634, 95%CI 0.476-0.844) were negatively correlated with the risk of muscle mass decline in elderly. The area under the ROC curve for predicting muscle mass decline velated to sarcopenia in elderly by using BMI and PhA was 0.893 (95%(70.855-0.931) and 0.786 (95%CI 0.736-0.837), respectively. The sensitivity was 0.724 and 0.676, respectively. The specificity was 0.916 and 0.762, respectively. When IIMI combined with PhA predicted muscle mass decline in the elderly, the area under the ROC curve was 0.917 (95%C7 0.883-0.951). The sensitivity was 0.867, and the specificity was 0.860. elderly is found. Conclusinn aCCI is correlated with muscle mass decline associated with sarcopenia in the elderly. As BMI and PhA decrease, the risk of muscle mass decline in the elderly increases. The combination of BMI and PhA has a high predictive value in muscle mass decline in the elderly. No predictive value of chronic diseases comorbidities in muscle masa decline related to sarcopenia in the [ABSTRACT FROM AUTHOR]

The interactions of chiral Ru (Ⅱ) polypyridyl complexes 1 and 2 with DNA were explored theoretically. Firstly, the DNA-docking models of chiral complexes 1 and 2 were constructed and optimized. The sequence of DNA binding affinity of chiral Ru (Ⅱ) complexes 1 and 2, i.e. Kb (Λ-1) ＜ Kb (Δ-1) ＜ Kb (Λ-2) ＜ Kb (Δ-2), was explained by the calculated DNA-binding energies. Besides, the sequence of DNA-cleavage efficiencies (?) of these complexes, i.e., ? (Λ-2) ＞ ? (Δ-2) ＞ ? (Λ-1) ＞ ? (Δ-1), were explained by the calculated electron-transfer activation energies and nature charges. Finally, the cause of DNA photolysis was analyzed by the molecular orbitals of docking structures. [ABSTRACT FROM AUTHOR]

As a lipopeptide produced by various strains of Bacillus spp., surfactin is composed of a cyclo-heptapeptide head group connected to β-hydroxy fatty acids with a chain length of 12 to 17 carbon atoms by endosomal bonds. It is a very powerful biosurfactant and has significant biological functions. In this paper, we reviewed the structure, biosynthesis model and the role of surfactin lipopeptides in biological control of plant diseases. Surfactin is synthesized by non-ribosomal peptide synthetases, which endows the structural diversity of surfactin family members. Previous studies found that the action mechanism of surfactin lipopeptides in biological control of plant disease mainly are in four ways. 1）It caused damage to the cell membrane of pathogen, resulting in its cell membrane rupture or osmotic pressure imbalance. 2）It inhibited the reproduction of pathogen. 3）It induced systemic resistance（ISR）in plants. 4）It promoted the colonization of biocontrol strains or the formation of their biofilms. The current information about surfactin using genetic engineering techniques is also highlighted to guide the biosynthesis of surfactin and to develop new derivatives. Surfactin is rich in physical and chemical properties due to its high structural diversity, which can be associated with a variety of biological activities and may have a wider range of applications in different fields. With the increasingly in-depth research on the biosynthesis of surfactin, more new lipopeptides with high performance and wide application will be developed, which will provide the basis for further research and biocontrol application of surfactin. [ABSTRACT FROM AUTHOR]

This paper reviews the diagnostic criteria, epidemiology, hazards, mechanisms, risk factors, risk assessment and targeted care of urinary tract infection (UTI) in patients with ureteral dermatostomy. The paper proposes the necessity of constructing and promoting a scientific and feasible early risk warning score for urinary tract infection in patients with ureteral dermatostomy for these potential risk factors. The aim is to provide a reference for the study of risk factors of urinary tract infection in ureteral cutaneous stomy patients, the development of an early warning model, and the formulation and implementation of clinical decision-making. [ABSTRACT FROM AUTHOR]

Lanthanide ion-doped upconversion luminescent nanomaterials with unique nonlinear Anti-Stokes luminescence have broad applications in life sciences, photonic transport, programmable control, and information encoding and decoding. Rare-earth-doped orthogonal luminescent nanocrystals are a major emerging research direction in the field of luminescence in recent years, which is based on the upconversion luminescence mechanism to realize the multifunctional integration of orthogonal luminescence on a single nanoparticle in a reasonable core-shell structure design, broadening the optional range and spatio-temporal tunability of spectra to further promote its application in related fields. This review summarizes the recent progress in the design optimization of synthetic rare-earth-doped orthogonal luminescent nanocrystals, and systematically discusses the regulation process of achieving orthogonal luminescence via energy transfer of rare-earth ions based on core-shell structures construction, as well as presents its applications in frontier fields such as information security anti-counterfeiting, bioimaging and therapy. Furthermore, the current challenges and future prospects of orthogonal luminescence are also summed up. [ABSTRACT FROM AUTHOR]

Objective To investigate the impact of ephedrine on knee osteoarthritis (KOA) in rats by regulating AMPK/NF-κB signaling pathway. Methods KOA rat models were established and grouped into Sham group, KOA group, Ephedrine group (40.0mg/kg), and Ephedrine group (40.0mg/kg)+Compound C group (0.2mg/kg). After drug grouping intervention, the knee joint width and pain threshold of rats were measured respectively,the pathological changes of cartilage tissue were observed with safranine O-solid green staining and Mankin score was performed,the levels of TNF-α, IL-1β and COX-2 in synovial fluid were detected by ELISA,the expression of IL-1β and MMP-13 proteins in cartilage tissue was detected by immunohistochemistry,Western blot was applied to detect the level of AMPK/NF-κB pathway related proteins. Results Compared with Sham group, the cartilage tissue of KOA group was seriously damaged,the knee joint width, Mankin score, levels of TNF-α, IL-1β, COX-2 in joint fluid, and levels of IL-1β, MMP-13, and p-NF-κB p65/NF-κB p65 in cartilage tissue were significantly higher, and the pain threshold and the level of p-AMPK/AMPK in cartilage tissue were significantly lower (P<0.05);compared with KOA group, the pathological damage of cartilage tissue in Ephedrine group was reduced,the knee joint width, Mankin score, levels of TNF-α, IL-1β, COX-2 in joint fluid, and levels of IL-1β, MMP-13, and p-NF-κB p65/NF-κB p65 in cartilage tissue were significantly lower, and the pain threshold and the level of p-AMPK/AMPK in cartilage tissue were significantly higher (P<0.05); compared with the Ephedrine group, the injury of cartilage tissue in the Ephedrine+Compound C group was aggravated,the knee joint width, Mankin score, levels of TNF-α, IL-1β, COX-2 in joint fluid, and levels of IL-1β, MMP-13, and p-NF-κB p65/NF-κB p65 in cartilage tissue were significantly higher, and the pain threshold and the level of p-AMPK/AMPK in cartilage tissue were significantly lower (P<0.05). Conclusion Ephedrine can inhibit NF-κB signal pathway, inhibit inflammatory reaction and improve cartilage injury in KOA rats by activating AMPK pathway. [ABSTRACT FROM AUTHOR]

Objective To explore; th(i preeliertive; value; of machine learning methods for hyperlipidemia in the e;lele;rly, and analyze; the; risk factors for hyperlipidemia in the; clelcrly. Methods The; stratified random edustcr sampling meitheiel was uscel te» se;le;e;t 5 759 edelcrly people; aged 60 anel above; in 27 communities in 9 e'ountics anel municipalities of Weifang City, anel the; health examination data of these; edelcrly people; in 2020 was collected. Missing or unusual data were; excluelcel, anel 4 534 edeler adults were; eventually inedueicel in the; stuely. Ten important risk factors we;re; scree;ne;el out by univariate; analysis, which was used to construct support vce;tor machines, decision trees, XGBoost, CATBoost anel LightGBM risk preeliertion moeleds, anel AUG (Area unelcr ROC curve), accuracy, accuraeiy, recall, anel Fl value; were; uscel te) evaluate; its performance. Results The; comprehensive; performance; e»f the; CATBoost machine; learning rnoele;! was the; best anel its AUC, precision, accuraey, recall anel Fl values were; 0. 82, 76. 49%, 92. 46%, 78. 68%, anel 0. 85, respectively. In the; process of CATBoost rnoele;! prediesting the; risk e»f hypcrlipielcmia in the; edelcrly, nine; variables were; more; important for the; pre;elie;tion e»f hyperlipidemia risk, anel their importance; was in the; orde;r of high te; bottom; systedie; blooel pressure;, waist circumference, fasting blooel glucose, boely mass inelex, diastolic blooel pressure;, smoking, age;, alcohol consumptiem, anel gender. Moreover, after rnoele;! optimization, it was found that only including these; nine; factors coulel be;tte;r pre;elie;t risks. Conclusion The; risk preeliertion mode;! of hypcrlipielcmia in the; clelcrly based on the; CATBoost machine; learning me;thod has a gejeiel prediction e;ffe;ct, which can provide; a reference; for the; pre;ve;ntie)n anel treatment of hypcrlipielcmia in the; clelcrly. [ABSTRACT FROM AUTHOR]

Objective: To study the relationship between the angiomotin (Amot) and Yes-associated protein 1 (YAP1) expression and clinicopathological parameters and prognosis in type I endometrial cancer (EC) tissues. Methods: 75 type I EC patients who were diagnosed and treated in Affiliated Hospital of Xuzhou Medical University from January 2014 to June 2017 were selected as the study object (EC group), 30 patients with pathologically confirmed atypical hyperplasia endometrial tissue specimens diagnosed and treated during the same period were selected as the atypical hyperplasia endometrial group, and 30 patients with pathologically confirmed normal endometrial tissue specimens during the same period were selected as the normal endometrial group. The Amot and YAP1 protein expressions in each group were detected by immunohistochemistry. Spearman rank correlation was used to analyze the correlation between Amot and YAP1 protein expression in type I EC cancer tissues. The differences of Amot and YAP1 protein expression in cancer tissues of type I EC patients with different clinicopathological characteristics were compared. Kaplan-Meier analysis (Log-rank test) was used to analyze the relationship between the expression of Amot and YAP1 protein and the survival prognosis of type I EC patients. Univariate and multivariate COX regression analysis was used to analyze the factors affecting the survival prognosis of type I EC patients. Results: The positive rates of Amot and YAP1 protein expression in type I EC tissues were 80.00%(60/75) and 85.33%(64/75), respectively, which were significantly higher than those in atypical hyperplasia endometrial tissue 43.33% (13/30) and 46.67% (14/30), and the difference was statistically significant (all P＜0.05). The positive rates of Amot and YAP1 protein in atypical hyperplasia endometrial tissue were significantly higher than those in normal endometrial tissue with 16.67% (5/30) and 20.00% (6/30), and the difference was statistically significant (all P＜0.05). There was a significant positive correlation between Amot and YAP1 protein expression in type I EC cancer tissues(P＜0.05). The positive rates of Amot and YAP1 protein expression in EC type I patients with different International Federation of Gynecology and Obstetrics (FIGO) stages, histological grades and lymph node metastasis were statistically significant (P＜0.05). The cumulative survival time of Amot-positive expression typeⅠEC patients was significantly lower than that of Amot-negative expression typeⅠEC patients (P＜0.05). The cumulative survival time of patients with YAP1-positive expression of typeⅠEC was significantly lower than that of patients with YAP1-negative expression of typeⅠEC (P＜0.05). Amot-positive expression, YAP1 positive expression, FIGO stage Ⅲ and lymph node metastasis were independent risk factors for poor prognosis in patients with EC type I (P＜0.05). Conclusion: The Amot and YAP1 protein positive expression increased in type I EC cancer tissues, which are related to FIGO stage, histological grade and lymph node metastasis. The positive expression of Amot protein and YAP1 protein is one of the risk factors affecting the poor prognosis of patients with type I EC. [ABSTRACT FROM AUTHOR]

Illumina Miseq high-throughput sequencing technology was used to investigate the differences in endophytic fungal and bacterial community structure between healthy and diseased needles of Taxus cuspidata in artificial and natural forests. The results showed that the changes of fungal OTU (Operational Taxonomic Units) were small and the changes of bacterial OTU were large. The natural forest had more fungal OTU number than the artificial forest, and the difference of bacterial OTU number was smaller. There were 9 fungal OTUs in the four groups, accounting for 9. 37% of the total fungal OTU. There were 34 identical bacterial OTUs in the four groups of samples, accounting for 4. 19% of the total bacterial OTU. At the phylum level, the fungal community composition in the samples before and after infection was basically the same, but degree of relative abundance was significantly different. Compared with the natural forest, the relative abundance of Ascomycota was higher in the artificial forest. Ascomycota was dominant in the four groups of samples. The bacterial community structure and relative abundance changed greatly before and after infection. There were more bacterial species in artificial forests than in natural forests. At the genus level, Genolevuria was the most dominant fungus in healthy leaves of plantations. Dothiora was the most dominant fungus in diseased leaves of plantations, Buckleyzyma was the most dominant fungus in known genera of healthy leaves of natural forests. Genolevuria was the most dominant fungus in the known genera of diseased leaves in natural forests. Ralstonia was the most dominant bacteria in healthy leaves of plantations, 1174-901-12 was the most dominant bacteria in diseased leaves of plantations, Sphingomonas was the most dominant bacteria in known genera of healthy leaves of natural forests. Massilia was the most dominant bacterium in the known genus of natural forest leaf disease. It was speculated that Alternaria and Seimatosporium may cause leaf blight of Taxus cuspidata [ABSTRACT FROM AUTHOR]

Taking agricultural waste straw as raw material, magnetic biochar was first prepared by pyrolysis, and then magnetic iodine-containing biochar nanocomposites with photo-response were prepared by solvothermal method. In order to test the application effect of the prepared materials, the adsorption and photocatalytic degradation of the dye rhodamine B（Rh B） in water were studied using the prepared materials as adsorbent and photocatalyst. The results show that the prepared composite has the structural characteristics of magnetite Fe3O4. After combining with iodine, the saturation magnetization of the sample decreases, but it can still be absorbed by the external magnetic field. The prepared samples have larger specific surface area, total pore volume and larger pore size. The material has an irregular shape and structure, and elements such as Fe, O and I are evenly distributed in the matrix structure of the main biochar. The results of adsorption-photocatalysis experiments show that the prepared composite has high adsorption and photocatalysis properties, making the maximum degradation rate of Rh B reach 94.71%. It realizes the purpose of “turning waste into treasure” and “treating waste with waste”, and provides methods and guidance for the effective utilization of other agricultural and forestry wastes and urban garbage, which has a good practical application prospect.  [ABSTRACT FROM AUTHOR]

Taking the inappropriate practices in existing research pointed out by a leading expert in clinical prediction models as examples, this paper introduced common misunderstandings in clinical prediction model research, explained why specific practices will jeopardize the model quality, and how to avoid repeating the same mistakes in future studies. The feasibility of using ChatGPT to provide methodological guidance is discussed by evaluating the answers given by ChatGPT. [ABSTRACT FROM AUTHOR]

In order to understand the recent epidemic status of brucellosis in cattle and sheep (referred to as brucellosis) in Baiyun Obo mining area, and provide references for the prevention and control of brucellosis in livestock, the tiger red plate agglutination test (RBPT) method was used to detect the serum of cattle and sheep in Baiyun Obo mining area from 2018 to 2022 to analyze the prevalence of brucellosis. The results showed that from 2018 to 2022, a total of 38 farmers and 5435 serum samples were tested, and 25 (sheep) positive serum were tested, with an average individual positive rate of 1.83%. Among them, there were three positive farmers, and the average positive rate of farmers was 5.36%. The positive rates of (sheep) individuals in each year were 0, 0, 1.12%, 0.71% and 0. The positive rates of farmers were 0, 0, 16.67%, 9.09% and 0. The positive rates of 2018 and 2019 were 0, which suddenly increased in 2020 and followed by a downward trend. According to the statistics of different livestock species, the average individual positive rate of cattle and sheep was 0 and 0.36%, respectively. The results found that the incidence of brucellosis in Baiyun Obo mining area from 2018 to 2022 was at a low level, and the average individual positive rate was only 1.83%, indicating that the prevention, control and purification of brucellosis in the whole region had a significant effect. The study also found that the incidence of brucellosis in female animals was higher than that of male animals, and the onset of brucellosis was mostly from July to August, which was different from the common time distribution of brucellosis. [ABSTRACT FROM AUTHOR]

The surface tension, wetting emulsification time and salt thickening effect of the mixed solution were tested after the compounding of sodium fatty alcohol polyoxyethylene ether sulfate (AES) and sodium dodecylbenzene sulfonate (LAS). The results showed that the surface properties of the mixed solution were most suitable for multi-system use when AES accounted for about 20% of the total active content; the viscosity of the AES/LAS mixed solution was significantly enhanced in the presence of NaCl. [ABSTRACT FROM AUTHOR]

Objective: To compare and analysis the application values of four-dimensional volumetric ultrasonography and color Doppler ultrasonography in the diagnosis of fetal anomalous pulmonary venous connection (APVC). Methods: A retrospective analysis method was used. From January 2019 to January 2022, 60 cases of pregnant women with abnormal fetal pulmonary vein drainage who were diagnosed and treated in our hospital were selected as the research subjects. Four-dimensional volume ultrasound and color Doppler ultrasound were given to diagnosis, and to record the images characteristics and determine the diagnostic values. Results: In the 60 pregnant women, there were 51 cases were diagnosed as fetal pulmonary venous drainage by color Doppler ultrasonography, and the diagnostic sensitivity was 85.0 %. Four-dimensional volume ultrasonography judged 59 cases of fetal pulmonary vein ectopic drainage, the diagnostic sensitivitye was 98.3 %. The diagnostic sensitivity of fetal pulmonary vein ectopic drainage by four-dimensional volume ultrasonography were significantly higher than that by color Doppler ultrasonography (P<0.05). The diagnostic specificity of both color Doppler ultrasonography and four-dimensional volume ultrasonography were 100.0 %. There were 32 cases were diagnosed as supracardiac type and 28 cases were inferior cardiac type. The pulmonary vein drainage route of supracardiac type was pulmonary vein-vertical vein-right superior vena cava (22 cases), pulmonary vein-vertical vein - Left superior vena cava (10 cases), the subcardiac type of pulmonary vein drainage route is pulmonary vein-vertical vein-left brachiocephalic vein-right superior vena cava (6 cases), pulmonary vein-vertical vein-portal vein (22 cases). There were 32 cases of cardiac malformation, and the combined malformation rate was 53.3 %; There were 51 cases of pregnant women terminated their pregnancy, 9 cases of pregnant women continued pregnancy, 8 cases of pregnant women were died in the neonatal period without treatment, and 1 case was died at 3 months of age. Conclusion: Compares with color Doppler ultrasound, the application of four-dimensional volume ultrasound in the diagnosis of fetal pulmonary venous drainage can improve the diagnostic sensitivity, can effectively reflect the pulmonary venous return, and can guide early clinical intervention. [ABSTRACT FROM AUTHOR]

Once the drainage pipe is blocked,its water delivery capacity will be reduced, and the operation of the drainage system in the area will be affected seriously. For pressure flow drainage pipes, computational fluid dynamic (CFD) simulations were carried out to analyze the relationship between the pressure distribution and the blockage height / length / location when analyzing the blockage characteristics under different situations. It was concluded that in the benchmark working condition, the flow velocity increases in the region from 0 to 3 m above the blockage position and decreases in the region from 0 to 5 m below the blockage position, and a water tongue is formed below the region. The abrupt change of influence on pressure exists within 5 m after the blockage position along the flow direction of the pipeline. The clogging causes a pressure in the front position of the blockage, and a pressure loss occurs in the rear. After the instantaneous blockage, there is no significant influence on the flow state and pressure in the far point. [ABSTRACT FROM AUTHOR]

With the rapid increase in the prevalence rate of nonalcoholic fatty liver disease（NAFLD）, new treatment methods are needed to prevent disease progression to liver fibrosis, liver cirrhosis, and liver cancer. Although great efforts have been made to clarify the pathological mechanisms of NAFLD disease progression, there are still no effective treatment methods at present. Bile acids（BAs） regulate systemic metabolism by activating nuclear receptors and G protein-coupled receptors and have been identified as important signaling molecules involved in lipid, glucose, and energy metabolism. Dysregulation of BA homeostasis is associated with the severity of NAFLD. This article summarizes the important ligands in BA metabolism and their role in the progression of NAFLD, in order to provide a basis for the treatment of NAFLD by targeting BA messengers. [ABSTRACT FROM AUTHOR]

Breast cancer is the most common malignant tumor in women and the main cancer causing death in females. Breast cancer therefore seriously threatens women's health and life span. Although there are a variety of comprehensive and multidisciplinary treatments for different types of breast cancer, the overall prognosis of advanced breast cancer remains unsatisfactory. The incidence of breast cancer is increasing year by year, and the age of onset is gradually decreasing, making the discovery of a breakthrough in breast cancer treatment a major problem that needs to be solved urgently. A large number of studies have shown the growth of breast cancer cells can be inhibited by inducing ferroptosis. Acid sphingomyelinase has also been confirmed to be involved in cell death induced by ferroptotic agonists. This article reviews the progress in the use of acid sphingomyelinase and ferroptosis in the treatment of breast cancer, and summarizes the mechanism of ferroptosis in breast cancer cells and its correlation with acid sphingomyelinase. This review will provide a theoretical foundation for seeking new therapeutic targets for breast cancer. [ABSTRACT FROM AUTHOR]

Silicon photonics is the core technology in the post-Moore ’ s era, characterized by the deep integration of optoelectronics and microelectronics. Silicon photonics can leverage the existing complementary metal-oxide-semiconductor (CMOS) infrastructure to fabricate low power consumption, high integration density, fast transmission speed, and highreliability silicon photonic chips which are widely employed in data centers and communication systems. At present, most optoelectronic devices like Si-based photodetectors and Si-based optical modulators have realized on-chip integration except for the Si-based lasers as essential light sources. The directly epitaxial III-V materials on silicon substrates is recognized as one of the most promising solutions to achieve low-cost and large-size monolithic integration of Si-based lasers, still facing many significant challenges. In this paper, the research progress of Si-based light sources is presented from the aspects of directly epitaxial on-axis III-V/ Si (001) substrates, on-axis Si-based laser materials, epitaxy technology and monolithic integration at first. Then the achievements in Si-based directly epitaxial quantum well lasers and quantum dot lasers in our group are reported in detail, including the growth of antiphase domains-free GaAs/ Si (001) substrates, epitaxial materials of InGaAs/ AlGaAs quantum well lasers and InAs/ GaAs quantum dot lasers, and fabrication of novel coplanar electrode structures of silicon photonic chips in parallel mode. [ABSTRACT FROM AUTHOR]

Objective To summarize the clinical efficacy of programmed management for H-type congenital tracheoesophageal fistula (H-TEF). Methods From March 2017 to March 2022, clinical data were retrospectively reviewed for 10 H-TEF children under programmed management.Six neonates developed recurrent cough after feeding and 4 infants had recurrent pneumonia.One case was associated with congenital heart disease and another had hemivertebra deformity of thoracic vertebra.After a definite diagnosis was confirmed by esophagography and/or fiberbronchoscope, gastric tube feeding was initiated.After inflammatory parameters normalized completely or partially and pneumonic change disappeared on chest film, a catheter was placed in fistula under a guidance of fiberbronchoscope.The position of fistula was confirmed by bedside radiography; H-TEF was repair through a cervical approach when fistula was located above T2 level and thoracoscopically below T2. Results Seven cases were confirmed by esophagography and 3 cases by fiberbronchoscope.Catheter was successfully deployed in fistula in all cases before surgery.Seven cases of fistula above T2 were repaired through a right cervical route and 3 cases of fistula below T2 underwent thoracoscopy.Feeding through a gastric tube resumed the next day and esophagography 1 week later.There was no leakage or recurrence during a follow-up period of (8-60) month.Three cases of hoarseness occurred after cervical surgery and recovered at (1-6) month.No dysphagia or recurrence was noted. Conclusion An integrated strategy for H-TEF yields satisfactory outcomes under programmed management. [ABSTRACT FROM AUTHOR]

Too many types of congenital esophageal atresia with a great diversity and variability bring dilemmas to clinical management. In clinical cases of first-stage end-to-end esophageal anastomosis, operative failure and error occur frequently due to inaccurate preoperative examinations and evaluations. Subsequent treatment becomes extremely difficult so that therapeutic efficacy is poor. Subsequent complications and sequelae adversely affect the quality of life. Based upon an etiological analysis of actual clinical cases, this review proposed practical and feasible clinical measures of avoid surgical failures and operative errors to improve the therapeutic outcomes of esophageal atresia. [ABSTRACT FROM AUTHOR]

Objective: To explore the relation of fear of missing out to social network site use and self-esteem in the college students. Methods: Totally 732 college students in Shandong Province were selected and tested with the Fear of Missing Out scale ( FoMOs), Social Network Site Intensity Scale ( SNSIS), and Self-Esteem Scale (SES). Results: The scores of FoMOs and SN SIS were higher in the urban college students than in the rural college students ( Ps < 0. 05). Regression analysis showed that after controlling the place of residence and grade, the interaction between social network site use and self-esteem negatively predicted the fear of missing out of college students ({3 = - 0. 02, P <0. 001) . A simple slope analysis showed that high self-esteem individuals ( B = 0. 22) could alleviate social network site use of fear of missing out, while low self-esteem individuals ( B = 0. 38) could improve the fear of missing out level in the use of social network site. Conclusion: It suggests that self-esteem may moderate the relationship between social network site use and fear of missing out in college students. [ABSTRACT FROM AUTHOR]

BACKGROUND: In oral implant repair, soft tissue level implants are different from bone level implants, which adopt non-embedded surgical methods. A good neck design can promote bone bonding or reduce marginal bone absorption and facilitate the formation of stable soft tissue sealing. Therefore, the neck structure design of implants is one of the key factors for the success of implant repair. OBJECTIVE: To simulate and analyze the stress distribution of implant components and implant-bone interface during the restoration of mandibular molars with four different smooth collar implants using three-dimensional modeling and finite element analysis software. METHODS: The cone-beam CT image data of a patient undergoing mandibular first molar implantation were selected, and the mandible model was established by Mimics 21.0 software. The mandible model was imported into Solidworks 2018 software. Smooth neck implant models were constructed as follows: the standard conventional cervical implant (2.8 mm in height, 4.8 mm in diameter), standard wide cervical implant (2.8 mm in height, 6.5 mm in diameter), aesthetic conventional neck implant (1.8 mm in height, 4.8 mm in diameter), and aesthetic wide neck implant (1.8 mm in height, 6.5 mm in diameter). The four models were repaired with pure titanium base table and zirconia full-crown screw fixation. The von-Mises stress distribution of implant components and the implant-bone interface in four groups of different smooth collar implants were compared and analyzed under vertical and oblique loadings. RESULTS AND CONCLUSION: (1) Whether it was vertical loading or oblique loading, the peak values of von-Mises stress were located in the neck region of the implant, and the peak values of von-Mises stress at the implant-bone interface were located in the cortical bone region of the neck region of the implant. (2) When using the same smooth collar implant, compared with the vertical loading group, the peak values of Von-Mises stress were greater in the four different smooth collar implants in the oblique loading group. (3) Under vertical or oblique loading, the maximum von-Mises stress of the standard implant group was greater than that of the standard implant group, and the maximum von-Mises stress of the aesthetic implant group was lower than that of the aesthetic implant group. (4) The maximum von-Mises stress on the implant-bone interface in the wide-neck standard implant group was lower than that in the other smooth cervical implant groups, regardless of vertical or oblique loading. (5) The results showed that the stress distribution of implant components and implant-bone interface was different with different smooth collar implants. [ABSTRACT FROM AUTHOR]

In order to study the effects of microstructure and mechanical properties of 20Cr carburized steel high-speed linear guide under different aging treatment conditions, the microstructure, phase composition and residual stress of linear guide before and after aging treatment were analyzed by scanning electron microscopy (SEM), Х-ray diffractometer（XRD) and X-ray stress tester. The results show that after aging treatment, the martensite structure in the surface layer of 20Cr carburized steel is gradually refined, the fine carbides is precipitated and some residual austenite decompose, the surface hardness of the guide rail increases and the maximum hardness is 729.3HV1/5. Affected by the transformation of residual austenite structure and the change of ferrite content, the residual stress of the carburized layer of the guide rail is eliminated to varying degrees. After heated to 200 °C for 13 h, the residual stress relief effect on the surface of the guide rail is the most obvious, the residual stress value is reduced to-127.17 MPa and the elimination rate is as high as about 54.05%,and there is a polynomial function relationship between the residual stress and the depth of the carburized layer. [ABSTRACT FROM AUTHOR]

In the process of bearing fault diagnosis of wind turbine, the fault diagnosis method based on deep learning is limited by limited labeled samples, which has problems such as difficulties in model convergence and low recognition accuracy. For this purpose, a parallel convolutional neural network（P-CNN) and feature fusion-based fault diagnosis method for small sample wind turbine bearings was proposed. Firstly, the vibration signal of the bearing was decomposed into several intrinsic mode functions (IMF） components and residual components by ensemble empirical mode decomposition（EEMD). Then, the short time Fourier transform (STFT) was performed on them, and they were respectively converted into time-frequency characteristic maps, and multiple identical convolutional neural network branches were constructed as feature extractors. Finally, the extracted time-frequency domain features were fused in the fusion layer and used as the input of the final classifier to achieve fault identification of wind turbine bearings, the applicability and effectiveness of this method was validated using different size bearing datasets from Case Western Reserve University. The results show that the parallel convolutional neural network (P-CNN) and feature fusion-based fault diagnosis method has an average accuracy of 94.5% when containing only 160 samples, which has higher accuracy and stronger robustness compared to support vector machine (SVM) 、FaultNet and deep convolutional neural networks with wide first-layer kernel (WDCNN). [ABSTRACT FROM AUTHOR]

BACKGROUND: In oral implant restoration, patients with single missing maxillary anterior teeth often have alveolar bone absorption and defect due to different reasons. To avoid the risk of bone grafting, inclined implants are often used to avoid the alveolar bone absorption area. The angle abutment is used to restore the normal overcovering relationship of patients. The size and distribution of the influence of different abutment materials on the occlusal force transfer of the implant and the surrounding bone were studied. OBJECTIVE: To compare the influence of time on the peak value of bone stress around the implant with three abutment materials under simulated dynamic loading under three implantation conditions. METHODS: Cone beam CT data of a healthy adult undergoing implant restoration of maxillary central incisor were selected. Minics software was used to cut the jaw bone. Solidworks 2018 was used to establish the implant, jaw bone, and angle abutment (angle 0°, 15°, and 25°). Base stations materials included pure titanium, zirconium dioxide, and alumina), central screw, and zirconium dioxide full porcelain crown model. Assembly was complete, for embedded in the original maxillary fang root cutting direction 0° angle, then simulated palate to tilt 15° and 25°, no implanted implant thread exposure. According to different implant angles, they were divided into 0°, 15°, and 25° groups. Dynamic loading was performed for 0.2 seconds, to obtain the time-dependent relationship between the peak value of equivalent stress of bone around the implant prosthesis of each material abutment. RESULTS AND CONCLUSION: (1) All abutment implant restorations had the same peak distribution of surrounding bone stress when they were subjected to occlusal force, all of which were located in the bone cortex of the implant neck. The fastest time period for the increase of bone stress around abutment implant restorations of each material was within 0.025-0.05 seconds. The range of high stress value of cortical bone in the 15° group was larger than that in the 0° group. The initial stress value of cortical bone of implant in the 25° group was significantly higher than that of the other two groups. The residual stress value of cortical bone was higher after loading. After titanium abutment implantation, the bone stress around the prosthesis had the largest increase, and the range of high stress value was relatively concentrated. (2) In the 15° group, the peak value of bone stress around the implanted prosthesis on the abutment of the three materials was located in the neck of the implant. The increase in bone stress around the titanium abutment implanted prosthesis was relatively large but not obvious, and the distribution range of high stress was relatively consistent. Compared with the other two groups, the high stress value of the 25° group was more concentrated; the initial stress value was higher and the range of change was greater, among which the bone stress around the implanted prosthesis on the dialumina abutment increased the most within 0-0.1 seconds. At 0.2 seconds, the peak value of bone equivalent stress of zirconia abutment decreased to 0, and high residual stress remained in the bone around the implants of the other two abutments. (3) It is concluded that based on the analysis of the distribution of different influences of the implant angle and abutment material on the bone interface, the bone stress of the implants using zirconia abutment was relatively stable at all time points in the three groups. [ABSTRACT FROM AUTHOR]

Shear keys play an important role in the safety of immersed tunnel joints. Based on the Ruyifang Immersed Tunnel project, the elastic damage model of concrete was introduced to characterize the joint shear force and the load-structure method was used, in which the effect of stratum on the immersed tunnel was made equivalent to the load on the immersed tunnel, to further build a three-dimensional FEM refined model for immersed tunnel joints to investigate the stress, shear force and damage of shear keys under two differential settlement conditions, i.e., vertical compression shear and transverse torsion. The results show that the terminal corners of the shear keys are all under compression, and the stress of the shear keys under the vertical compression-shear is greater than that under the transverse torsion; Under the compression shear, the shear keys of the middle walls and lateral walls bear most of the vertical shear force and the increase in the shear force begins to slow down when the differential settlement is greater than 25 mm. The vertical shear force is mainly shouldered by shear keys of the lateral wall with larger settlement and the two middle walls under the transverse torsion, while the horizontal shear keys bear most of the horizontal shear force. The damage value increases obviously when the differential settlement is greater than 25 mm for compression shear condition, causing the shear failure combined with tension and compression. The damage of shear keys under transverse torsion condition is less than that under the compression shear condition, thus, the shear key is in a safe state. [ABSTRACT FROM AUTHOR]

In order to improve the theoretical system of piston pump performance analysis, the effect of different speed on the oil film lubrication properties of piston pair in eccentric state was studied. Firstly, the mathematical models of the plunger pair oil film thickness field, pressure field and temperature field were built. Then, the Reynolds equation and the energy equation were discretized used the finite volume method and solved by successive over relaxation（SOR）algorithm. Finally, the oil film properties of the plunger pair were simulated by MATLAB software. The effect of speed on the pressure field and temperature field of the oil film in the oil pressure area in one cycle was obtained. The research results indicate that the eccentric load of the plunger produces a squeeze effect. As the speed increases, the peak value of the oil film pressure increases more rapidly. When speed is 3 000 r/min, the peak pressure reaches 63.87 MPa. The shape of the temperature field of the plunger pair oil film at different speeds is basically the same. The higher the speed is, the greater the plunger eccentricity is, and the faster temperature increases. When speed is 3 000 r/min, the local temperature peak at the oil film reaches 62.2 ℃. The results provide a theoretical basis for further improving the lubrication performance of the plunger pair of the plunger pump. [ABSTRACT FROM AUTHOR]

Background and purpose: Perineural invasion is a prognostic factor in colorectal cancer. It is unclear whether perineural invasion is a prognostic factor in in node-negative (ypⅠ-Ⅱ) rectal cancer patients who received neoadjuvant radiotherapy because there may be varying degrees of tumor regression. This study aimed to investigate prognostic value of perineural invasion in node-negative rectal cancer patients who received neoadjuvant radiotherapy. Methods: A total of 5 222 patients who received neoadjuvant radiotherapy and were diagnosed with stage ypⅠ-Ⅱ rectal cancer from the Surveillance, Epidemiology, and End Results (SEER) database between 2000 and 2018 were identified and clinicopathological features and cancer-specific survival outcomes were retrospectively analyzed. Chi-square analysis was used to compare clinicopathological features between two groups. Kaplan- Meier survival analysis and the log-rank test were used to estimate the 5-year cancer-specific survival. Multivariable Cox regression analyses were used to identify the independent prognostic factor. Results: Compared with patients without perineural invasion, patients with perineural invasion were more likely to be black, have elevated carcinoembryonic antigen (CEA), stage Ⅱ disease, tumor＜5 cm and poorer differentiated tumors (P＜0.05). Patients without perineural invasion had superior cancer-specific survival than those with perineural invasion (5-years survival rate: 85.3% vs 68.9%). The survival difference was more evident in patients with stage ypⅡ cancer. Multivariable Cox regression analyses demonstrated that perineural invasion was an independent prognostic factor in node-negative rectal cancer patients who received neoadjuvant radiotherapy. Conclusion: Perineural invasion is associated with oncological outcomes of node-negative rectal cancer patients who received neoadjuvant radiotherapy, thus it could serve as a prognostic factor in these patients. [ABSTRACT FROM AUTHOR]

Objective To analyze the relationship between blood pressure variability (BPV) and hyperuricemia in patients with essential hypertension. Methods A total of 197 patients with essential hypertension were divided into the non-hyperuricemia group (n=143) and the hyperuricemia group (n=54) according to whether they were accompanied by hyperuricemia. The participants were divided into four groups according to the serum uric acid (SUA) quartile, the group Q1 (n=49) with SUA≤282.35 µmol/L, the group Q2 (n=50) with 282.35 µmol/L < SUA≤332.40 µmol/L, the group Q3 (n=49) with 332.40 µmol/L < SUA≤406.65 µmol/L, the group Q4 (n=49) with SUA > 406.65 µmol/L. All patients completed 24- hour ambulatory blood pressure monitoring within 3 days of admission. The general data, biochemical indexes and blood pressure related indexes were collected and compared between the two groups. LASSO regression was used to screen the predictors of hyperuricemia. Multivariate Logistic regression analysis was used to test risk factors of hyperuricemia. Results The prevalence of hyperuricemia in patients with essential hypertension was 27.4%. Compared with the non-hyperuricemia group, the proportion of males and hypertension grade were higher in the hyperuricemia group, and the levels of body mass index (BMI), triglyceride (TG), serum creatinine (Scr), blood urea nitrogen (BUN) and uric acid (SUA) were increased. Glycated hemoglobin A1c (HbA1c), high density lipoprotein cholesterol (HDL-C), uric acid excretion fraction (FEUA) and estimated glomerular filtration rate (eGFR) were decreased in the hyperuricemia group (P＜0.05). With the increase of hypertension grade, the proportion of the Q2 group gradually decreased, while the proportion of the Q4 group gradually increased, and the difference in trend change was statistically significant (χ2 =4.578, P＜0.05). Compared with the nonhyperuricemia group, the mean daytime diastolic blood pressure (DDBPX), mean nighttime diastolic blood pressure (NDBPX), weighted standard deviation of diastolic blood pressure (DBPwSD) and heart rate variability (HRV) were significantly increased in the hyperuricemia group (P＜0.05). LASSO regression was used to select hypertension grade, DBPwSD, TG, eGFR and FEUA as independent variables. Logistic regression analysis demonstrated that elevated levels of DBPwSD and TG were risk factors for hyperuricemia, and elevated levels of eGFR and FEUA were protective factors for hyperuricemia. Conclusion Diastolic BPV is an independent risk factor for hyperuricemia in hypertensive patients. [ABSTRACT FROM AUTHOR]

Shanggong Gold Deposit is located in the north of Xiongershan Gold Field. Based on the study of the regional geological background, geological characteristics, and characteristics of ore-forming fluids of Shanggong Gold Deposit, it is considered that the evolution of ore-forming fluids of Shanggong Gold Deposit has 4 stages. The ore inclusions are dominated by gas-liquid two-phase inclusions, which commonly occur with the gas-liquid ratio of 5 %-10 % and possibly occur with 5 %-30 %;the most favorable metallogenic temperature is 200 ℃-300 ℃;the fluid is with a medium-high salinity, mainly between 5 % and 10 %,8.9 % on average; the ore-forming pressure is 80-93 MPa; the ore-forming fluid mainly belongs to the NaCl-CO,CO2-H2O system containing halogen and alkaline water solution. When the temperature decreases and the ore-forming stage proceeds to the post-mineralization stage, the ore-forming solution changes from weak acidity to weak alkalinity. The results can be used as a reference to study the characteristics of ore-forming fluids in similar gold deposits in the region. [ABSTRACT FROM AUTHOR]

The stagnation cap model is used to study the heat transfer characteristics of contaminated bubbles in shear-thinning fluids. The results show that the effect of rheological index on the bubble heat transfer is relatively small but the Reynolds number and the contamination degree of bubble interface has the great influence on it; with the increase of Reynolds number and/or the decrease of stagnation cap angle, the thermal boundary layer around the bubble becomes thinner and the heat transfer becomes good; and the average Nusselt number increases with the decrease of stagnation cap angle and the increase of the Reynolds number. [ABSTRACT FROM AUTHOR]

Aimed at the internal short circuit problem due to large deformation of the prismatic lithium-ion battery cell under impact loadings, a simplified battery model was first established. Then the motion equations of velocity and displacement based on the membrane factor method were proposed. With the effects of the face-sheet thickness and the densification region on the normalized final deflection, impact response characteristics of prismatic battery cells were investigated in detail. The results show that, the improved motion equations involving the membrane factor can reflect the dynamic response mechanisms of the prismatic battery cell under impact loadings, and the large deflection under high-speed impact can be predicted. With the increase of the face-sheet thickness, the deflection of the battery cell ’s lower part decreases obviously. However, the densification region expands with the face-sheet thickness. The deflection and the [ABSTRACT FROM AUTHOR]

The tumor microenvironment plays an important role in the proliferation, invasion and metastasis of cholangiocarcinoma cells. Complicated functional axis determines cholangiocarcinoma heterogeneity and its malignant potential. Targeting some factors in the tumor microenvironment might help reshape immune system of the tumor microenvironment to enhance natural anti - tumor immune responses. As a consequence, the improved immune environment and enhanced immune function will have great clinical potential in prediction of immune response to immunotherapy and identification of novel therapeutic strategies, which can provide a new potential direction for further investigation of targeted therapy of cholangiocarcinoma. [ABSTRACT FROM AUTHOR]

Objective To investigate the value of DETERMINE score in differentiating right ventricular outflow tract premature ventricular contraction (RVOT-PVC) and arrhythmogenic right ventricular cardiomyopathy (ARVC). Methods Twenty-five patients with ARVC and 59 patients with RVOT-PVC were retrospectively analyzed. Their ECG parameters and characteristics of sinus rhythm were compared. DETERMINE score was calculated based on the number of leads with pathological Q waves, fragmented QRS complex, and T wave inversion. Results ARVC group in sinus rhythm has higher incidences of epsilon waves (12. 00% vs. 0, P < 0. 01), T wave inversion in leads V1 - V3 (68. 00% vs. 37. 29%, P = 0. 010) and ventricular tachycardia with left bundle branch block morphology (52. 00% vs. 16. 95%, P = 0. 001). The single ECG characteristic above is poor in identifying ARVC (sensitivity < 70. 0% ). The DETERMINE score in the ARVC group is significantly higher than that in the RVOTPVC group [(5. 80 ± 2. 56) vs. (0. 58 ± 1. 22), P < 0. 01]. The sensitivity and specificity of higher DETERMINE score( > 3) are separately 92. 0% and 91. 5% while positive and negative predictive values are 82. 8% and 98. 2%, respectively. Conclusion Simple DETERMINE score can be utilized to differentiate ARVC from RVOTPVC. The score system has certain clinical application value. [ABSTRACT FROM AUTHOR]

A field experiment for the AD268 with large leaf and dwarf structure and the XY335 with small leaf and high structure at three planting densities of low (3 plants·m-2), medium (6 plants·m-2) and high (9 plants·m-2) was conducted. This study integrated the vertical distribution of canopy photosynthetically active radiation (PAR), a 3D canopy model, and a canopy photosynthesis model to analyze responses of the extinction coefficients estimated by the logarithmic approach (klog) and the regression approach (knls) to cultivar and density and their differences, and to evaluate the effects on simulating canopy light utilization. The results showed that there was a difference between klog and knls, and this difference was more obvious for AD268 and aggravated with increasing density. The fitness based on knls for canopy light distribution (R2=0.86) was better than klog (R2=0.77). The daily CO2 assimilation, above-ground dry matter accumulation and radiation use efficiency of AD268 simulated by klog and knls did not differ significantly at low densities, but the difference became larger with increasing density. The critical densities at which the difference become larger were 0.7-2.5plants·m-2. [ABSTRACT FROM AUTHOR]

BACKGROUND: Stroke has become one of the thorny diseases facing the world due to its high morbidity, high mortality, high disability rate, and high recurrence rate. However, traditional rehabilitation methods, characterized by slow effect, low efficiency, and dull training, elicit little effects in the treatment of stroke. With the development of science and technology, virtual reality technology which has the characteristics of simplicity, high efficiency, high security, strong interest, low price, and real-time feedback can solve the imbalance of doctor-patient ratio, promote the development of remote rehabilitation medicine, and has extremely important practical significance for the rehabilitation of stroke patients. OBJECTIVE: To study the research hotspots and progress of virtual reality technology in stroke treatment using Citespace V knowledge graph software, and to clarify the structural model of this field and predict the possible development trends of virtual reality technology worldwide in the future. METHODS: A total of 1 374 core articles addressing virtual reality technology published since 2007 were retrieved from Web of ScienceTM, CNKI, CSSCI, and CSCD database and used as data sources. Citespace V knowledge graph software was used to analyze the research status of virtual reality technology in stroke treatment. In addition, the domestic and foreign differences in disciplines, countries, authors, institutions, and research hotspots were compared. Then, the possible development trend in the future was predicted. RESULTS AND CONCLUSION: The foreign countries have formed a multi-disciplinary and multi-domain comprehensive group, focusing on neuroscience, computer science, and biomedical engineering. Domestic disciplines are relatively monotonous, and no obvious discipline group has formed. There is a network of close exchanges and cooperation that has formed between foreign countries/regions, authors, and institutions, forming a high school mentality of countries, authors, and institutions. The cooperation among domestic authors, groups and institutions is poor, with geographical restrictions, and there is a lack of influential academic groups and institutions. There are differences in research contents at home and abroad, and there have been four development stages of this technology in foreign countries. The possible trends of future research abroad are the research, development and evaluation of remote rehabilitation medicine, robot-assisted therapy, and virtual rehabilitation system, highlighting the screening of virtual rehabilitation therapy. The possible future research topics in China may be the effect and evaluation of the combined treatment of specific parts with virtual reality technology and other methods, and the introduction and development of advanced technology. [ABSTRACT FROM AUTHOR]

With the development of shale gas, infilling the existing horizontal well pattern is the key to later development. Continuous exploitation of old wells will cause redistribution of pore pressure and in-situ stress. The redistribution of in-situ stress has a significant impact on the fracture propagation behavior and path. In order to explore the influence mechanism of in-situ stress redistribution on fracture propagation behavior, based on the block discrete element numerical simulation method, the influence characteristics of the change of in-situ stress field on the hydraulic fracture propagation of infill wells were studied. The effects of injection rate, fracturing fluid viscosity, in-situ stress gradient and initial in-situ stress on hydraulic fracture propagation were considered. The results show that the decrease of in-situ stress caused by old wells will lead to the migration of hydraulic fractures from new wells to old wells. Increasing injection rate and fracturing fluid viscosity can reduce hydraulic fracture migration caused by non-uniform in-situ stress. The larger the in-situ stress gradient and the higher the initial in-situ stress field, the higher the hydraulic fracture migration rate. This study has a certain theoretical significance for the formulation of shale gas horizontal well infill program. [ABSTRACT FROM AUTHOR]

To obtain the road potholes condition timely and effectively for improving the driving safety of intelligent vehicles, the non-contact pothole detection method and the active obstacle avoidance control algorithm were designed based on road pothole detection. The road pothole features were extracted by multi-sensor fusion technology, and area calculation and contour extraction of road potholes were conducted based on visual images. By single point ranging laser radar, the pothole depth was measured. The vehicle model and the road pothole model were built by Adams. According to the evaluation index of human comfort, the limit speeds for different size potholes were determined. The active obstacle avoidance algorithm of road pothole was designed based on the fuzzy control theory. The Simulink/Carsim co-simulation was carried out to verify the algorithm. The results show that the algorithm can meet the system design requirements for controlling the vehicle to safely and comfortably pass through the road potholes and effectively reduce the accident rate of vehicles under dangerous conditions. [ABSTRACT FROM AUTHOR]