胆管癌肿瘤微环境与免疫治疗.

The tumor microenvironment plays an important role in the proliferation, invasion and metastasis of cholangiocarcinoma cells. Complicated functional axis determines cholangiocarcinoma heterogeneity and its malignant potential. Targeting some factors in the tumor microenvironment might help reshape immune system of the tumor microenvironment to enhance natural anti - tumor immune responses. As a consequence, the improved immune environment and enhanced immune function will have great clinical potential in prediction of immune response to immunotherapy and identification of novel therapeutic strategies, which can provide a new potential direction for further investigation of targeted therapy of cholangiocarcinoma. [ABSTRACT FROM AUTHOR]