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Researchers at Jinan University in Guangzhou, China have published a report on pharmaceutics, focusing on the measurement of drug release kinetics. The study aimed to develop a method for real-time visualization and quantification of drug release from microspheres in vitro. The researchers used fluorescence imaging with the FRET system to monitor drug release and found a correlation between fluorescence alterations and drug release profiles. This research has implications for enhancing therapeutic effectiveness and minimizing side effects. [Extracted from the article]

A study conducted by researchers at the University of Limerick in Ireland explores the effects of atomisation gas flow rate on the properties and bioactivity of particles used in pulmonary inhalation of biotherapeutics. The study aims to develop techniques that engineer particles to specific target profiles while minimizing protein denaturation. The results show that optimizing the interplay between atomisation gas flow rate and excipient concentration can produce free-flowing powder with retained bioactivity approaching 100%, low moisture content, and small particle size. This research provides valuable insights for the design of protein-specific spray-drying parameters for inhalable biotherapeutics. [Extracted from the article]

A recent study conducted at the University of Greifswald in Germany focused on the development of long-lasting mucoadhesive oral dosage forms for the treatment of esophageal diseases. The researchers utilized the EsoCap device for targeted local application of films in the esophagus. They also explored different formulation strategies, such as varying film thicknesses and polymer grades, to increase the retention time of the films. The study highlights the importance of biorelevant test systems and the potential of viscous saliva formulations in extending the mucosal contact time. For more information, the full research article can be accessed through the provided link. [Extracted from the article]

Researchers from the University of Chile have developed a new type of core-shell micromotor for use in photothermal therapy (PTT). The micromotor combines magnetic and photothermal properties and is synthesized using iron (Fe) and reduced graphene oxide (rGO). The micromotors respond to magnetic forces and near-infrared (NIR) light, achieving a high photothermal conversion efficiency. Preliminary results show low cytotoxicity and strong accumulation, suggesting that these micromotors have potential for combined photothermal therapy. [Extracted from the article]

A recent study conducted by researchers at the University of Banja Luka in Bosnia and Herzegovina focused on the design of novel TRPA1 agonists, which are compounds that can activate TRPA1 channels in the body. The researchers aimed to investigate the role of TRPA1 channels in carvacrol-induced vasodilation and design new compounds based on carvacrol's structure with improved activities. Through in vitro and in silico studies, the researchers found that carvacrol-induced vasodilation is partly mediated by the activation of TRPA1 channels. They also identified a specific compound, D27, as the best candidate for further synthesis and experimental evaluation. This research has implications for the treatment of hypertension and the development of new vasodilator drugs. [Extracted from the article]

A study conducted by Rentschler Biopharma SE in Laupheim, Germany, has developed a clonal and high-yield mammalian cell line for the manufacturing of a hyperactive human DNase I with an extended plasma half-life using PASylation technology. The research aims to improve clinical outcomes by restoring plasma DNase activity in a thrombo-inflammatory state. The study resulted in a stable TurboCell CHO-K1-based cell line suitable for the production of PASylated DNase I, which exhibited a 14-fold higher DNA-degrading activity than the approved recombinant form of DNase I. The protein product also demonstrated a sustained pharmacokinetic profile with a 22-fold slower clearance in rats. [Extracted from the article]

Researchers from Dankook University have conducted a study on the pharmacokinetics and enterohepatic circulation of 2-(quinoline-8-carboxamido)benzoic acid (2-QBA) in mice. 2-QBA is a quinoline alkaloid that has been suggested as a potential treatment for Parkinson's disease. The researchers developed an analytical method using liquid chromatography-tandem mass spectrometry (LC-MS/MS) to measure the concentration of 2-QBA in mouse plasma. They found that the oral bioavailability of 2-QBA ranged from 68.3% to 83.7% and identified glucuronide metabolites of 2-QBA. The study suggests that the reabsorption of orally administered 2-QBA contributes to its high oral bioavailability and could enhance its efficacy as a drug. [Extracted from the article]

Researchers from the Petru Poni Institute of Macromolecular Chemistry in Iasi, Romania have developed a method for creating pharmaceutical formulations of the antibiotic enrofloxacin (ENR) using polymer-free electrospinning. ENR is commonly used in veterinary medicine but has limited water solubility and low bioavailability. The researchers used custom-prepared cyclodextrin-oligolactide (CDLA) derivatives to improve the solubility of ENR and incorporated significant amounts of the antibiotic into CDLA nanofibrous webs. The formulations were found to have antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, and the presence of CDLA did not inhibit the antibacterial activity of ENR. Further development of these formulations is recommended. [Extracted from the article]

A new study on pharmaceutics conducted in Beijing, China has found that the encapsulation of sodium sulfobutylether-b-cyclodextrin (SBE-b-CD) is influenced by both the degree of substitution (DS) and the presence of strong-bonded water (SBW). The study revealed a positive correlation between DS and SBW, with molecular polarizability being a possible mechanism. The study also explored the impact of SBW on encapsulation and found that for SBE-b-CD with DS of 2 and 3, an increase in enthalpy hindered guest entry, while for SBE-b-CD with DS of 4 and 7, the influence of SBW was minimal. The research aims to enhance the understanding of factors affecting the encapsulation of SBE-b-CD for quality control and functional development purposes. [Extracted from the article]

A recent study conducted by researchers at Teva Pharmaceutical Industries Ltd. explores the development and therapeutic application of long-acting injectable products for chronic or long-term treatments. The study focuses on TV-46000, a subcutaneous injectable formulation of risperidone used to treat schizophrenia in adults. The researchers used physiologically-based pharmacokinetic modeling and in vitro-in vivo correlation to predict the pharmacokinetic profile of TV-46000 in humans. The results suggest that the release profile of TV-46000 is species-dependent and cannot be directly extrapolated from dog to human. The study concludes that this alternative approach combining modeling methods is valuable for complex injectable formulations where traditional methods are not applicable. [Extracted from the article]

A recent study conducted at Argonne National Laboratory in Illinois has found that amorphous Indomethacin, a drug used for pain relief, has enhanced bioavailability compared to its crystalline forms. The study used Empirical Potential Structure Refinement (EPSR) to accurately model the molecular structure of different amorphous Indomethacin samples. The results showed that the majority of molecules in amorphous Indomethacin are non-bonded or bonded to one neighboring molecule via a single hydrogen bond, unlike the doubly bonded dimers found in the crystalline state. The study also found a significant variation in hydrogen bonding between different amorphous forms, leading to a diversity of chain structures. These findings were supported by NMR studies of the hydrogen bond dynamics in amorphous Indomethacin. For more information, the full research article can be accessed for free at the link provided. [Extracted from the article]

A recent report published by AbbVie Deutschland GmbH & Co. KG discusses the challenges of developing drugs with complex chemical structures, known as 'beyond rule of five' (bRo5) compounds. These compounds often have difficult physicochemical properties, making it challenging to measure their permeability using the Caco-2 assay. The researchers implemented a novel assay that improved the measurement of permeability for bRo5 compounds, achieving comparable performance to the standard assay for predicting human absorption. This optimized equilibrated Caco-2 assay provides a high-throughput method for measuring cellular permeability in the bRo5 chemical space. [Extracted from the article]

A recent study conducted by researchers at Zhejiang Chinese Medical University in Hangzhou, China, has developed a novel treatment for androgenetic alopecia (AGA), a common condition characterized by hair loss. The researchers created a minoxidil-incorporated engineered exosomes biopotentiated hydrogel (Gel@MNs) that can effectively deliver minoxidil to the hair follicles. In an AGA mouse model, Gel@MNs demonstrated accelerated hair regeneration without causing significant skin irritation. The study suggests that this hybrid exosome-embedded hydrogel has promising potential for the clinical treatment of AGA. [Extracted from the article]

A researcher from Heilongjiang University of Chinese Medicine has conducted a systematic review of biomaterials used in wound healing, focusing on their immune-modulatory properties. The review highlights the importance of immune regulation in wound healing and explores the impact of various factors on the immune response during healing. The study examines a range of biomaterials, including hydrogels, collagen scaffolds, and 3D-printed constructs, and discusses their immunomodulatory approaches. The research concludes by discussing recent advancements and prospects in biomaterials that accelerate skin wound healing through immune modulation. [Extracted from the article]

Researchers at the State University of Campinas (UNICAMP) in Brazil have developed a versatile nanostructured lipid carrier (NLC) for the incorporation and stability of the anesthetic drug butamben. NLCs are composed of liquid lipids, solid lipids, and surfactants, allowing for the encapsulation of lipophilic drugs. The researchers optimized the surfactant system and found that stable NLCs were obtained using specific surfactants. The study also found that the addition of a hydrophilic excipient helped in stabilizing the system and decreasing particle size. The research concluded that while some NLC formulations showed phase separation or precipitation, they could be freeze-dried to avoid these issues in an aqueous medium. [Extracted from the article]

Researchers at the University of Szeged in Hungary have published a new report on pharmaceutics. The study focuses on the discovery of new bioactive compounds in the African plant Centrapalus pauciflorus, which has traditionally been used in medicine for chest pain and stomach aches. The researchers isolated three new meroterpenoids from the plant, as well as a known compound. These compounds showed moderate but selective activity against certain cancer cell lines. The findings suggest that these compounds could be potential targets for the development of new drugs. [Extracted from the article]

A study conducted by researchers at China Pharmaceutical University has developed a new method for delivering small interfering RNA (siRNA) therapeutics to cancer cells. The researchers created a family of ferrocenyl amphiphilic dendrimers (Fc-AmDs) that respond to high levels of reactive oxygen species (ROS) in cancer cells. One specific dendrimer, Fc-C [ [8] ] -AmD 8A, demonstrated optimal siRNA delivery and gene silencing. This research represents a novel on-demand delivery system for cancer cell-specific siRNA delivery and opens new possibilities for designing self-assembly nanosystems for drug delivery. [Extracted from the article]

A recent study conducted by the University of Torino in Italy has found that essential oils, when used in combination with traditional antifungal agents, show promise in fighting resistant clinical isolates of Candida auris, a pathogen that has become a global health concern. The study found that certain essential oils, such as thyme, cinnamon, geranium, clove bud, lemongrass, and mentha of Pancalieri, were effective in preventing the growth of C. auris. Additionally, combinations of these essential oils with antifungal drugs, such as micafungin, fluconazole, and 5-flucytosine, showed synergistic effects against the pathogen. These findings suggest that these essential oil combinations could potentially be used as a therapeutic alternative to reduce the dose of individual components and limit side effects, offering a potential solution to the challenge of resistance in C. auris infections. [Extracted from the article]

A study conducted by researchers at the University of Barcelona explores the development of multitarget compounds for the treatment of Alzheimer's disease. The researchers focused on simplifying the structure of a lead compound to improve its drug metabolism and pharmacokinetic properties. Through a stepwise process of structural simplification, they were able to create new analogs that exhibited enhanced potency on multiple targets related to Alzheimer's disease, as well as improved safety and pharmacological properties. This research provides valuable insights into the optimization of drug leads through structural simplification. [Extracted from the article]

Researchers from the University of Minho in Portugal have developed electrospun fibers that can inhibit the activity of enzymes and bacteria in diabetic ulcers. The fibers, made from a blend of polycaprolactone (PCL) and polyethylene glycol (PEG), were loaded with elastase-targeting peptides AAPV and WAAPV. The study found that WAAPV effectively regulated proteolytic enzymes by inhibiting human neutrophil elastase (HNE), while both peptides demonstrated antibacterial efficacy against Staphylococcus aureus and Escherichia coli. These findings suggest that the WAAPV-loaded fibers have potential applications in the management of diabetic ulcers. [Extracted from the article]

A recent study conducted by Sinopharm Group in Beijing, China has found that milk exosomes can be isolated on a large scale at a low cost and have various benefits for the skin. Exosomes are small membrane vesicles that are secreted by most cells and can regulate the condition of recipient cells. Milk exosomes have been found to promote the synthesis and reconstruction of stratum corneum lipids, enhance skin barrier function, provide protection for the skin, reduce skin irritation and redness, exhibit antioxidant activity, inhibit melanin production, and aid in skin whitening. These findings have implications for the use of milk exosomes in cosmetics, skin healthcare, and other fields. [Extracted from the article]

Researchers from Simulations Plus Inc. have developed a new method to facilitate the development of generic ophthalmic drug products with complex formulations. The study focuses on the use of ocular physiologically based pharmacokinetic (O-PBPK) models to predict human exposure following the administration of ophthalmic suspension. The researchers successfully demonstrated the utility of the O-PBPK model to predict human ocular exposure after the topical administration of Besifloxacin (Bes) suspension. The findings suggest that this modeling and simulation approach can aid in the development of ophthalmic generic drug products. [Extracted from the article]

A report from Jinan University discusses the role of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs) in regulating tyrosine phosphorylation in proteins. PTKs were once considered promising targets for cancer therapy, but face challenges such as drug resistance and side effects. The report highlights the potential of PTPs as viable therapeutic targets and discusses strategies and prospects for PTP-targeted therapy. The research suggests that with advances in allosteric inhibition and alternative drug strategies, PTPs are now considered "druggable" targets. [Extracted from the article]

A recent study conducted by researchers at the University of Bisha explores the use of microneedles for drug delivery, diagnostics, and cosmetic treatments. The study focuses on the design and manufacture of customized microneedle arrays using laser ablation. The researchers found that the laser pulse width and interval significantly affect the diameter and height of the microneedles. This research lays the groundwork for the development of customized microneedles for therapeutic applications such as dermal sensors, drug delivery, and vaccine delivery. [Extracted from the article]

Researchers at the Institute for Medicinal Plants Research in Belgrade, Serbia, have conducted a study on the development of encapsulation systems for preserving the polyphenols in everlasting flower extract. The researchers formulated spray-dried encapsulates using cyclodextrins and conventional carriers, and evaluated their technological, physicochemical, and phytochemical properties. The study found that the combination of cyclodextrins with whey protein provided the highest encapsulation efficiency and preservation potential for the extract. Overall, the research suggests that the use of cyclodextrins and conventional biopolymers in the spray-drying process can enhance the functional properties of everlasting flower extract. [Extracted from the article]

A recent study conducted by researchers at Minia University in Egypt explored the use of cyclodextrins and arginine to improve the solubility and tolerability of retinoic acid, an FDA-approved anti-aging formula. The researchers used molecular docking, solubility, thermal and spectral analyses, cytotoxicity, and scratch assays to investigate the effects of these substances. The results showed that cyclodextrins and arginine significantly enhanced the solubility of retinoic acid and reduced its irritation potential without compromising its efficacy. This research provides valuable insights for the development of more effective and patient-friendly anti-aging solutions. [Extracted from the article]

A recent study conducted at Ghent University in Belgium evaluated the potential of different grades of polyvinyl alcohol (PVA) as binders during continuous twin-screw wet granulation (TSWG) in pharmaceutics. The study found that PVA 4-88 was the most effective binder for both water-soluble and water-insoluble formulations due to its high total surface energy, low viscosity, good wettability, and good water solubility. The research concluded that PVA could be the preferred binder during twin-screw granulation, but process robustness must be controlled by the included excipients. This information is available in the journal article "Evaluation of Polyvinyl Alcohol as Binder during Continuous Twin Screw Wet Granulation" published in Pharmaceutics. [Extracted from the article]

A recent study conducted by researchers at the University of Kragujevac in Serbia aimed to develop a topical cream loaded with pine tar for the treatment of diabetic wounds. The researchers prepared an oil-in-water emulsion with 1% pine tar and assessed its stability and safety. The cream showed good physicochemical properties and remained stable for cutaneous application. The study found that the cream led to a remarkable increase in wound closure rate and improved redox status and hydroxyproline levels, suggesting its potential as a promising tool for the management of diabetic wounds. [Extracted from the article]

A recent study conducted by researchers at the Federal University of Bahia in Brazil explored the pharmacokinetics and lung penetration of a compound called 6-methoxyseselin, derived from Zanthoxylum tingoassuiba. The compound demonstrated various therapeutic properties, including antiasthmatic effects. The study involved administering the compound through inhalation and intravenous routes in mice, and the results showed favorable pharmacokinetic profiles and high lung penetration factors. This research suggests that 6-methoxyseselin has potential for further drug development as a new anti-asthmatic medication. [Extracted from the article]

A recent report published by researchers at the State University of New York (SUNY) highlights the lack of knowledge regarding the excretion of antidepressants into breast milk and its potential effects on infants. This lack of understanding often leads to depressed lactating mothers avoiding pharmacological treatment. Clinical lactation studies are the most accurate method to predict the excretion of antidepressants into breast milk, but there are limited trials and studies due to ethical and enrollment issues. To address this knowledge gap, alternative methods are needed to estimate the concentration of antidepressants in breast milk. The researchers provide a comprehensive review of cost-effective and ethically feasible methods that can be used to assess the safety and transfer of antidepressants into breast milk before conducting clinical studies. [Extracted from the article]

A recent report from the Graduate School of Engineering in Osaka, Japan, discusses the use of dendrimers as nanocarriers in drug delivery systems. The researchers synthesized carboxy-terminal phenylalanine-modified dendrimers and investigated their association with T-cells. They found that PAMAM-n-hexyl-Phe showed the highest association with Jurkat T-cells, while DGL-CHex-Phe had higher association but was insoluble in water. The researchers also loaded model drugs onto these dendrimers and found that PAMAM-CHex-Phe exhibited efficient T-cell association and drug loading properties. The study suggests that these dendrimers have potential applications in drug delivery systems. [Extracted from the article]

A new study conducted by researchers at Santa Clara University explores the quality control of genetically engineered exosomes, which are nanoscale vesicles derived from human cells that show promise for targeted drug delivery. The researchers used advanced gene fusion and transfection techniques to generate two sets of genetically engineered samples and employed dual-omics analysis to assess exosome quality. The study found that the engineered exosomes had increased levels of engineering scaffolds and identified various RNA species and proteins loaded onto the exosomes. The findings establish a framework for the quality control of engineered exosome products, facilitating their clinical translation and therapeutic applications in nanomedicine. [Extracted from the article]

A recent report from the First Hospital of Shanxi Medical University in Taiyuan, China discusses the use of astatine-211 (211At) as a potential radionuclide for targeted alpha therapy of cancer. The report highlights the challenges associated with the in vivo stability of 211At-labeled radiopharmaceuticals and provides an overview of current strategies for 211At radiolabeling. The review also discusses the preclinical and clinical applications of 211At-labeled radiopharmaceuticals, including small molecules, peptides, and antibodies. The researchers emphasize the need for further research and development in this field to fully realize the potential of 211At-based targeted alpha therapy in cancer treatment. [Extracted from the article]

A recent study conducted by researchers at Benemerita Autonomous University of Puebla in Mexico has explored the potential anticancer properties of citrulline, an amino acid found in the body. The researchers synthesized two new mixed complexes of citrulline with 1,10-phenanthroline and 2,2'-bipyridine, which showed promising results in in vitro toxicity studies on cancer cell lines. Docking studies with DNA also indicated potential anticancer activity. This research provides new insights into the field of pharmaceutics and may contribute to the development of novel anticancer therapies. [Extracted from the article]

Researchers at the Catholic University of Korea have conducted a study on the drug Zastaprazan, a novel potassium-competitive acid blocker used for the treatment of erosive esophagitis. The study found that Zastaprazan is highly metabolized in human, mouse, and dog hepatocytes, but moderately metabolized in rat and monkey hepatocytes. The cytochrome P450 enzymes CYP3A4 and CYP3A5 were found to play major roles in the metabolism of Zastaprazan, while drug transporters had a minimal impact on the absorption, distribution, and excretion of the compound. These findings suggest that drug-metabolizing enzymes may have a significant role in determining the pharmacokinetics of Zastaprazan. [Extracted from the article]

A recent report from the Faculty of Nursing and Health Sciences discusses research on the extraction of biologically potent compounds from Vaccinium myrtillus leaf waste. The study aimed to optimize the extraction process, characterize the extracted compounds, and investigate their biological potential. The researchers found that the optimal extraction conditions involved a plant material:medium ratio of 1:30 g/mL, 50% ethyl alcohol, and 2 minutes of microwave irradiation. The extracts showed high inhibition of Staphylococcus aureus growth, antioxidant capacity, stimulative influence on keratinocyte viability, and anti-inflammatory activity. The findings suggest that these bilberry extracts have potential applications in pharmacy and cosmetics. [Extracted from the article]

A recent study conducted by researchers at the University of Pittsburgh explores the use of polymeric microparticles (MPs) as a potential solution to the limitations of standard pharmaceuticals and their delivery methods. The study focuses on identifying critical processing parameters in the manufacturing process of double-emulsion poly(lactic-co-glycolic) acid MPs and their impact on various quality attributes. The results highlight the importance of understanding the manufacturing and characterization of these MPs, which could enhance their translation into clinical applications. This research provides valuable insights for the development of new drug delivery systems. [Extracted from the article]

A recent study conducted by Charles River Laboratories International Inc. in Budapest, Hungary, explores the use of in vitro models to predict brain penetration of drugs. The researchers used cell lines overexpressing MDR1 of human, mouse, rat, or cynomolgus monkey origin to investigate species differences. The study found good correlations between the cell lines and limited species specificities, suggesting that this assay system has the potential for early-stage brain penetration screening. However, the comparison between orthologs is complex and requires an understanding of modes of transporter inhibition. [Extracted from the article]

Researchers at the University of Alberta have conducted a study on drug absorption through chylomicrons, which has implications for pharmacokinetics and pharmacodynamics. The study aimed to understand the in vivo intestinal lymphatic uptake of drugs using an in vitro model. The researchers found that coconut oil had superior emulsification in artificial chylomicron media, leading to heightened uptake. They also discovered that the zeta potential of Intralipid® influenced intestinal lymphatic uptake. Further research is needed to explore the translation of these findings in vivo. [Extracted from the article]

A recent study conducted by researchers at Tabriz University of Medical Sciences in Iran explored the functional mechanisms of crocin, a water-soluble carotenoid found in saffron, in protecting cardiovascular health under oxidative stress. The study utilized in vitro and in vivo models to investigate the effects of crocin on human umbilical vein endothelial cells (HUVECs) and mice hearts. The results indicated that crocin exhibited protective effects on HUVECs and cardiac cells, inhibiting inflammation and modifying gene expression profiles. The research suggests that crocin acts as a direct free radical scavenger and has anti-inflammatory properties, potentially benefiting cardiovascular health. [Extracted from the article]

A recent study conducted by Guizhou Medical University in China investigated the effect of the pharmaceutical excipient PEG400 on the pharmacokinetics of baicalin, a compound found in traditional Chinese medicine. The study found that PEG400 influenced the concentration of baicalin in hepatocytes and increased its bioavailability. Additionally, PEG400 had an inhibitory effect on the efflux transporters involved in the metabolism of baicalin in the liver. These findings suggest that PEG400 can improve the effectiveness of baicalin by affecting its transporters. [Extracted from the article]

A research article from Dongguan, People's Republic of China, discusses the use of metal-organic frameworks (MOFs) in the diagnosis and treatment of kidney diseases. The article highlights the importance of addressing kidney-related diseases and the challenges faced in current technologies. MOFs have shown promise in detecting biomarkers related to kidney disease and can be used as adsorbents for uremic toxins during hemodialysis. They can also serve as intelligent drug delivery carriers and be combined with nano-chelation technology to address trace element imbalances. The article concludes by discussing the current challenges and prospects of MOFs in the field of kidney disease diagnosis and treatment. [Extracted from the article]

A recent study conducted by Pfizer Inc. examined the trends in amorphous solid dispersion (ASD) drug products approved by the U.S. Food and Drug Administration (FDA) between 2012 and 2023. The study found that 48 drug products containing ASDs were approved during this period, with 36 unique amorphous drugs represented. The majority of these drugs contained antiviral and antineoplastic agents. The study also discussed the manufacturing processes, dosage forms, and patient-centric dosing options of these ASD drug products. Overall, the study provides valuable insights into the formulation and manufacturing of ASDs and their use in therapeutic categories. [Extracted from the article]

A recent study conducted by the Agency for Science Technology and Research (ASTAR) in Singapore investigated the effect of process parameters on the microstructure, stability, and sensorial properties of an emulsion cream formulation. The study found that an oil phase above 15% and less than 10% emulsifying wax resulted in less stable emulsions. The researchers also discovered that a holding temperature of 35 °C improved both the stability and active release performance of the emulsion. This research provides valuable insights into the relationship between process parameters and the quality attributes of emulsion cream systems, which can aid in the design and optimization of manufacturing processes. [Extracted from the article]

A study conducted at the University of Pavia in Italy explores a new approach for predicting the absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of candidate drugs. The study utilizes attention-based graph neural networks (GNNs) to process a graph-based representation of molecules derived from Simplified Molecular Input Line Entry System (SMILE) notation. The model is tested using benchmark datasets and demonstrates effectiveness in predicting ADMET properties, providing a valuable tool for high-throughput screening and enhancing the likelihood of drug success in the development pipeline. The research article is available for free at the journal Pharmaceutics. [Extracted from the article]

Researchers at Chungbuk National University in South Korea have proposed a method to improve the dispersibility and aerodynamic performance of inhalable microparticles used in dry-powder inhalers (DPIs). By incorporating L-leucine (LEU) into hot-melt extrusion (HME), the researchers were able to enhance the dispersibility of the microparticles while maintaining their high aerodynamic performance. The study found that higher ratios of LEU in the HME formulations resulted in improved aerodynamic performance and particle size. This research shows promise for the development of inhalable particles that can improve drug dispersion and delivery. [Extracted from the article]

A study conducted by researchers at Chungbuk National University in South Korea explored the fabrication of mini-tablets using 3D printing technology and their correlation with release kinetics. The researchers successfully created mini-tablets of various polyhedral shapes containing theophylline, a drug used to treat respiratory conditions. They found that the Higuchi model and the surface area to volume ratio (SA/V) had the highest correlation (R2 = 0.995) in terms of release kinetics. This research suggests that 3D printing can be used to develop personalized or pediatric drug products by modifying the size or shape of the drug while maintaining the same release profile. [Extracted from the article]