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A Phase I study conducted in Marseille, France evaluated the combination of nivolumab, an immunotherapy drug, with three different metronomic chemotherapy regimens in children and adolescents with relapsing/refractory solid tumors. The study aimed to assess the feasibility and safety of the regimens. Sixteen patients were enrolled, and no dose-limiting toxicities were observed. Grade 3 adverse events were reported in 50% of patients, and the 6-month progression-free survival and overall survival rates were 12% and 44%, respectively. The study concluded that a randomized Phase II trial is currently underway to further evaluate the addition of nivolumab to the triple metronomic chemotherapy. [Extracted from the article]

A study conducted by Aix-Marseille University in Marseille, France, examined the educational outcomes of siblings of childhood leukemia survivors. The study found that siblings did not have a higher risk of educational delays at the end of middle school compared to the general population. However, certain factors such as older siblings, family financial difficulties, and a history of repetition in survivors were associated with a higher risk of repeating a grade. The researchers suggest that paying attention to siblings can help identify vulnerable families and provide appropriate resources to avoid long-term repercussions. They also recommend developing supportive and targeted interventions to improve education and the healthcare system. [Extracted from the article]

A recent study conducted by researchers at Aix-Marseille University in Marseille, France, examined the effects of medial opening wedge high tibial osteotomy (MOWHTO) on posterior tibial slope (PTS) and patellar height (PH). The study found that there were no significant changes in PTS or PH after MOWHTO when accurate preoperative planning and precise intraoperative freehand technique were used. The research involved 62 patients who underwent MOWHTO and were evaluated preoperatively and at a 2-year follow-up. The findings suggest that MOWHTO can maintain PTS and PH when performed correctly. [Extracted from the article]

Researchers at Aix-Marseille University have conducted a study on collisions against obstacles while skiing to better understand the impact conditions applied to the human body during these accidents. The study analyzed 201,805 snow sports accidents in France between 2014 and 2019, focusing on 3,393 collisions against obstacles. The research found that head protection is a priority due to the high frequency of head impacts, and trunk impacts also appeared to be at risk. The study's findings can be used to improve the design of safety measures, revise standards, and layout ski slopes more effectively. [Extracted from the article]

A recent study conducted in Marseille, France, examined the effects of nusinersen treatment on children with spinal muscular atrophy (SMA) over a period of 36 months. SMA is a rare genetic neuromuscular disorder that causes muscle atrophy. The study found that 93% of the patients showed improvement in motor skills over the course of the treatment. Patients with three copies of the SMN2 gene were more likely to have better outcomes in terms of respiratory, nutritional, and orthopedic complications compared to those with two copies. However, children with two copies of SMN2 had worse motor, respiratory, and orthopedic outcomes after 3 years of treatment. This research has been peer-reviewed. [Extracted from the article]

Researchers from the Service of Cardiology in Marseille, France conducted a study on the use of Micra AV leadless pacemakers after transcatheter aortic valve implantation (TAVI). The study aimed to assess the outcomes of patients who received Micra AV pacemakers after TAVI. The study found that the implantation of Micra AV pacemakers after TAVI was associated with a low complication rate and good device performance at the one-month follow-up. This research provides valuable real-world data on the use of Micra AV pacemakers in this specific patient population. [Extracted from the article]

A study conducted at University Hospital Nord in Marseille, France compared the Perkins applanation tonometer and the iCare rebound tonometer for measuring intraocular pressure (IOP) in children under general anesthesia. The study found that the IOP measurements obtained with both tonometers were highly correlated, although the iCare tonometer tended to overestimate IOP, especially for high values. However, no underestimation of IOP was found with the iCare tonometer, suggesting its potential for glaucoma screening in children. The study was published in the Journal Francais d'Ophtalmologie and has been peer-reviewed. [Extracted from the article]

A recent report from Aix-Marseille University in Marseille, France suggests that patients with long COVID may experience brain fog due to astrocyte dysfunction and glutamatergic dysregulation. The researchers found a glucose hypometabolic pattern in the brains of these patients, which may be indicative of primary astrocyte dysfunction. The study proposes that therapeutics targeting astrocytic glutamate regulation could potentially help alleviate neurological symptoms in long COVID patients. This research has been peer-reviewed and published in Medical Hypotheses. [Extracted from the article]

A report from La Conception University Hospital in Marseille, France, discusses the psychological impact of living kidney donation. The researchers conducted a systematic literature review, analyzing both qualitative and quantitative studies on the topic. The quantitative studies found that donor quality of life remained unchanged or improved, regret rates were low, and donor-recipient relationships remained stable or improved. However, qualitative studies revealed a more complex experience, with some donors regretting their decision but still recommending donation. The researchers emphasize the need for a better understanding of the impact on donors to provide better care. [Extracted from the article]

A recent study conducted in Marseille, France, examined the prevalence of psychiatric disorders among individuals detained for sexual offenses. The study found that the majority of the 142 male patients included in the analysis had at least one psychiatric disorder, with personality disorders being the most common. Other disorders observed included schizophrenic disorder, bipolar disorder, depressive disorder, pedophilic paraphilia, and addictive disorders. The study concluded that there is a need for structured assessment of recidivism risk to improve the management of sexual offenders. [Extracted from the article]

A recent study conducted by researchers at Aix-Marseille University in Marseille, France, has found that a specific modification to the RNA genome of the human immunodeficiency virus type-1 (HIV-1) impairs its ability to undergo reverse transcription. The modification, known as 2'-O-methylation, negatively affects the activity of the reverse transcriptase enzyme, which is crucial for viral replication. This finding suggests that the fine-tuning of RNA methylation during viral replication plays a role in the antiviral effects observed. The study provides new insights into the mechanisms of HIV-1 replication and may have implications for the development of future therapeutic strategies. [Extracted from the article]

A recent study conducted by Aix-Marseille University in Marseille, France, examined the efficacy and safety of maintenance olaparib and bevacizumab in older patients with newly diagnosed advanced ovarian cancer. The study found that the addition of olaparib to bevacizumab maintenance improved progression-free survival (PFS) in these patients. The research compared baseline clinical and molecular data, as well as PFS, between older and younger patients. The study concluded that older patients achieved similar PFS benefits compared to younger patients, with a similar safety profile. [Extracted from the article]

A recent study conducted by Aix-Marseille University in Marseille, France, examined the safety and feasibility of ureteroscopy (URS) for the treatment of urinary stones in children aged 5 years or younger. The study included 83 patients who underwent a total of 96 procedures. The researchers found that URS was a complex but minimally invasive procedure with reasonable efficacy and low morbidity in this age group. However, they noted that intrarenal stones treated by retrograde intrarenal surgery (RIRS) in young children may require additional procedures to achieve complete stone clearance. [Extracted from the article]

A study conducted in Marseille, France, evaluated the impact of continuous glucose monitoring (CGM) on the everyday life of young children with type 1 diabetes (T1D) and their parents. The study found that parents whose children used CGM reported improved sleep compared to those whose children used flash glucose monitoring (FGM). Additionally, a significant number of parents reduced their working hours or stopped working following their child's T1D diagnosis. The research highlights the importance of evaluating social needs, particularly of mothers, at the initial diagnosis of T1D in children. [Extracted from the article]

A recent report from Aix-Marseille University in Marseille, France, discusses the use of intraventricular baclofen (IVB) as a treatment for pediatric patients with generalized dystonia. The study presents four cases in which IVB resulted in significant improvements in mobility and motor function. The researchers also conducted a literature review to further explore the potential of IVB as a treatment modality. The findings of the study provide valuable insights for palliative management in similar cases. [Extracted from the article]

A recent study from Aix-Marseille University in Marseille, France, highlights the importance of medullary thyroid cancer, which accounts for less than 5% of thyroid cancers but is known for its heterogeneity and aggressive behavior. The study reveals that in 25% of cases, medullary thyroid cancer may be associated with a rare genetic tumor syndrome called multiple endocrine neoplasia type 2 (MEN-2). The research also discusses the discovery of mutations in the RET proto-oncogene, which were identified 30 years ago and are responsible for MEN-2. The study emphasizes the significance of the first drug targeting this pathway, coinciding with the 30th anniversary of the RET discovery. [Extracted from the article]

A new study from Aix-Marseille University in Marseille, France, examines the progress made in the management of atrial fibrillation (AF) over the past two decades. AF is the most common sustained arrhythmia encountered in clinical practice. The study discusses the clinical classification of AF, associated cardiovascular diseases, modifiable risk factors, and complications such as stroke and transient ischemic accidents. It also explores advancements in prevention, treatment strategies, and the use of implantable devices and non-vitamin K antagonists. The research concludes that significant progress has been made in both pharmacological and non-pharmacological management of AF. [Extracted from the article]

A recent study conducted by researchers at Aix-Marseille University in Marseille, France, explores the prevention and management of post-thyroidectomy cervical hematoma (PTCH). PTCH occurs in less than 5% of patients but can be fatal or result in severe neurological complications. The study recommends preoperative prevention in line with the French Society of Anaesthesia and Resuscitation's guidelines, intraoperative prevention focused on careful hemostasis, and postoperative measures such as maintaining normal blood pressure and controlling pain, coughing, nausea, and vomiting. The research emphasizes the importance of training medical teams to recognize and manage hematoma cases urgently. [Extracted from the article]

A report from Timone Hospital in Marseille, France discusses the importance of neuropsychological assessment in pediatric epilepsy surgery. The researchers conducted a systematic review of the literature and developed a consensus strategy for the evaluation of cognitive function in children undergoing epilepsy surgery. The goal of this procedure is to anticipate the functional risks of surgery, support postoperative outcomes, and consider the plasticity and vulnerability of the immature brain. This research provides a guide for pre- and post-surgical work-up in French centers with pediatric epilepsy surgery programs. [Extracted from the article]

A recent study conducted by researchers at Aix-Marseille University in Marseille, France, aimed to determine the prevalence of cardiovascular disease (CVD) and venous thromboembolism (VTE) risk factors in patients with ulcerative colitis (UC). The study included 1,071 patients with UC and found that more than one-third of patients had no cardiovascular risk factors, and around three-quarters had one or fewer risk factors. Additionally, more than 90% of patients had no strong VTE risk factors and one or fewer moderate risk factors. The researchers concluded that physicians should be aware of these factors in their patients. The study was supported by Pfizer and has been peer-reviewed. [Extracted from the article]

A report from Marseille, France discusses the use of artificial intelligence (AI) in the diagnosis of prostate cancer. The researchers developed a computerized artificial neural network analysis system called ANNA/C-TRUS, which analyzes transrectal ultrasound (TRUS) images of the prostate. The study found that ANNA/C-TRUS improved the diagnostic performance of conventional TRUS in detecting prostate cancer. However, further studies with more patients are needed to confirm these results. The use of AI in prostate cancer diagnosis shows promise and may help improve detection rates. [Extracted from the article]

A new study conducted at the University Hospital Center in Marseille, France, proposes a new method for calculating the intraocular lens (IOL) power in pediatric cataracts. The study collected data from children under the age of 15 who underwent cataract surgery with IOL implantation between 2005 and 2020. The researchers used a logarithmic regression model to predict axial length growth and aimed for emmetropia (normal vision) at the age of 15. The results showed that the estimated refractive error using the new logarithmic formula was closest to emmetropia at the last follow-up. This research has been peer-reviewed and published in Acta Ophthalmologica. [Extracted from the article]

A study conducted by Aix-Marseille University in Marseille, France aimed to determine the 30-day mortality rate and risk factors associated with death after renal trauma. The study analyzed data from 1,799 cases of renal trauma over a 10-year period and found a 30-day mortality rate of 3.27%. The study identified several factors that were independent predictors of death, including age over 40, hemodynamic instability, anemia, bilateral renal trauma, arterial contrast extravasation, and concomitant visceral and bone injuries. The findings of this study can help clinicians identify high-risk patients. [Extracted from the article]

A report from Aix-Marseille University in Marseille, France discusses the use of animal models, specifically rodents, to study the effects of adverse post-natal environments on the developing brain. The researchers focused on maternal separation (MS) paradigms and compared the effects of short (15 min, 3 times/day) vs. long (3 h, 1 time/day) separation on maternal behavior and offspring development. The results showed that short separation enhanced maternal care, while long separation resulted in poor caregiving. Additionally, the study found that MS had profound effects on social tasks and that interactions during the early post-natal period are crucial for emotional processing and brain development. [Extracted from the article]

A recent study conducted by researchers at Aix-Marseille University in Marseille, France, has found that the neutrophil:lymphocyte ratio (NLR) can be a predictive marker for the risk of death and cardiovascular events in patients with chronic kidney disease (CKD) who are undergoing hemodialysis (HD). The study involved 183 patients and found that higher NLR values were associated with increased levels of the uremic toxin indoxyl sulfate (IS) and a higher incidence of mortality and cardiovascular events. The researchers suggest that the NLR could be a useful marker for monitoring the risk of clinical events in CKD patients. [Extracted from the article]

A recent report from Aix-Marseille University discusses the potential benefits of cannabis in treating nonalcoholic fatty liver disease (NAFLD). The researchers highlight the endocannabinoid system (ECS) as a key target for treating NAFLD and suggest that the cannabis plant, with its diverse active compounds, could be a major prospect in the treatment of this condition. However, the report also acknowledges the need to overcome scientific and nonscientific barriers in order to further explore this potential treatment option. The research has been peer-reviewed and published in the journal Cannabis and Cannabinoid Research. [Extracted from the article]

A recent report from researchers at Aix-Marseille University discusses the neurological causes of vertigo in children. While vertigo is common in childhood and adolescence, the epidemiology changes with aging. The leading causes of vertigo in children are audiovestibular disorders, such as vestibular neuritis and migraine equivalent, rather than severe causes like ischemic stroke. The report emphasizes the importance of clinicians being aware of the signs of severity and conducting appropriate diagnostic approaches. [Extracted from the article]

Investigators at Aix-Marseille University Report Findings in Lordosis (Do Age-related Variations of Sagittal Alignment Rely On Spinopelvic Organization? Keywords for this news article include: Marseille, France, Europe, Bone Diseases and Conditions, Health and Medicine, Kyphosis, Lordosis, Musculoskeletal Diseases and Conditions, Orthopedics, Spinal Curvatures, Spinal Diseases and Conditions, Aix-Marseille University. Keywords: Marseille; France; Europe; Bone Diseases and Conditions; Health and Medicine; Kyphosis; Lordosis; Musculoskeletal Diseases and Conditions; Orthopedics; Spinal Curvatures; Spinal Diseases and Conditions EN Marseille France Europe Bone Diseases and Conditions Health and Medicine Kyphosis Lordosis Musculoskeletal Diseases and Conditions Orthopedics Spinal Curvatures Spinal Diseases and Conditions 2625 2625 1 11/06/23 20231110 NES 231110 2023 NOV 10 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on Musculoskeletal Diseases and Conditions - Lordosis. [Extracted from the article]

Keywords: Marseille; France; Europe; Anemia; Aplastic Anemia; Bone Marrow Diseases and Conditions; Health and Medicine; Hematologic Diseases and Conditions; Hematology; Hemic and Lymphatic Diseases and Conditions; Risk and Prevention EN Marseille France Europe Anemia Aplastic Anemia Bone Marrow Diseases and Conditions Health and Medicine Hematologic Diseases and Conditions Hematology Hemic and Lymphatic Diseases and Conditions Risk and Prevention 610 610 1 11/06/23 20231109 NES 231109 2023 NOV 9 (NewsRx) -- By a News Reporter-Staff News Editor at Blood Weekly -- Investigators publish new report on Bone Marrow Diseases and Conditions - Aplastic Anemia. According to the news editors, the research concluded: "GRFS was worse in cases of salvage allo-HSCT, most notably in older patients, questioning the utility of allo-HSCT earlier in the disease course.". [Extracted from the article]