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15 soil samples were collected, and 79 actinomycetes strains were isolated by dilution plate method. 5 strains with antagonistic effects on Colletotrichum gloeosporioides were obtained by plate confrontation and growth rate methods. The antagonistic rate of strain DTJ-24 was as high as 69. 89 %,and had good passage stability. Based on the morphological, biochemical characteristics and 16s rDNA gene sequence analysis,the strain DTJ-24 was identified as Streptomyces lavendulae. It is the first time to report that S. lavendulae have antagonistic effects on strawberry anthracnose. [ABSTRACT FROM AUTHOR]

Compared with traditional voting schemes, e-voting has been widely studied due to the advantages in contrast，including more security，more efficiency and lower cost. In 2012，Sun et al. proposed a multi-candidates e-voting scheme based on the secure sum, however? it did not really achieve the verifiability. In this paper，we present an improved version to satisfy the non-deception requirement and guarantee the correctness of the tally results. [ABSTRACT FROM AUTHOR]

The tomato seedling experiment was conducted to investigate the effect of substrate on the tomato seedling growth from five proportions of tea-leaf wormcast to peat, perlite and vermiculite, namely treatment I（1:5:2:2）, treatment II（2:4:2:2）, treatment III（3:3:2:2）, treatment IV（4:2:2:2）, treatment V（6:0:2:2）, respectively. The botany properties and characters of tomato seedling were observed to discuss the application effect of tea-leaf wormcast substrate. The results showed that in all treatments of the compound substrate of tea-leaf wormcast, except of treatment I, the tomato seedling indexes were superior to the control treatments（conventional seedling substrate in market）, and the treatments had the best effect, followed by treatment V. With the increasing proportion of tea-leaf wormcast, the plant height, stem diameter, SPAD value, and root morphology index of tomato seedlings firstly increased, and then decreased obviously. The substrate with the appropriate proportion of tea-leaf wormcast could obviously improve the quality of tomato seedlings, and the treatment IV was the best, which could be recommended for the actual production of tomato seedling. [ABSTRACT FROM AUTHOR]

目的探讨CT定向硬通逍技术在基底节区高血丨玉脑出血忠者中的应用效采方法 CT证实为基底节 区高血压脑出血患者133例，出血量25 ~60 mL，随机分为3组,其中内科治疗42例(保守组)，开颅血肿淸除术治 疗45例(手术组)，CT定向硬通逍技术治疗46例(微创组)。比较3组颅外并发症(呼吸道感染、秘路感染、消化逍 出血、低钠血症、肾功能不全、脑心综合征)发生率，治疗后3个月病死率及日常生活活动能力(ADL)结果微 创组呼吸道感染、尿路感染、肾功能不全、脑心综合症发生率低于保守组和手术组均<0. 05)与保守组和手术 组比较，微创组ADL1〜3级以上患者多(/>均<0.05)，微创组病死率低于保守组(/>均<0.()5)。结论 CT定向 硬通逍技术治疗基底节区高血压脑出血可降低颅外并发症发生率，改善日常生活活动能力。 [ABSTRACT FROM AUTHOR]

The study was to investigate the effect of combined application of exogenous glutamine and lanthanide polysaccharide (Gln-RIP) on intestinal morphology and absorption function in colostrum-free littermates by gavage. A total of 120 young rats were divided into five groups, with six replicates in each group. The rats in group A were fed with colostrum, the rats in group B were fed with normal milk + 0.9% saline, the rats in group C were fed with normal milk + 1 g/kg Gln, the rats in group D were fed with normal milk + 1 g/kg Gln+20 mg/kg RIP, and the rats in group E were fed with normal milk+1 g/kg Gln+40 mg/kg RIP. Gross anatomical techniques, D-xylose absorption assay, HE staining technique and Leica microscopic image processing system were applied to analyze the height of intestinal villi and depth of crypt in the colostrum-free litter group and colostrum group by gavage with different doses of Gln-RIP. The results showed that at 21 d, the weight of rats in group C, group D and group E was significantly higher than that in group A and group B (P<0.05). From 0 to 21 d, the length of small intestine increased with age. On 21 d, the height of duodenal villus in group D and group E was significantly higher than that in group B (P<0.05), and the jejunum crypt depth in group B and group D was significantly higher than that in group A (P<0.05). On 21 d, duodenal V/C value in group B was significantly lower than that in group E (P<0.05). On 21 d, the AV value in group A was significantly higher than that in group B (P<0.05), and that in group B was significantly lower than that in group E (P<0.05). The experiment indicates that Gln-RIP can promote the development of intestinal morphology and enhance the absorption function of small intestine in colostrum-free rats. [ABSTRACT FROM AUTHOR]

The experiment was to determine the slaughter performance and meat quality of Ji'an cattle and systematically evaluate meat potential. Six Ji'an cattle steers with intensive fattening were selected to measure their body size, carcass characteristics and meat quality. The results showed that the body weight of Ji'an cattle steers was 332.58 kg, wither height was 112.83 cm, cross height was 112.50 cm, body length was 118.67 cm, oblique length was 121.17 cm, heart girth was 181 cm, and cannon circumference was 17.33 cm. There were significant correlations between wither height, cross height, body length, oblique length, head length and body weight (P<0.05). The test beef carcass weight was 188.2 kg, dressing percentage was 56.62%, the meat percentage was 43.60%, dressing percentage of carcass was 77.01%, meat to bone ratio was 4.35, the eye muscle area were was 78.94 cm2 . After the right half carcass was cut, high-grade meat was 10.81 kg, accounting for 11.48%, hind leg meat was 20.39 kg, accounting for 21.66%, high-quality meat was 31.20 kg, accounting for 33.14%. The cooked meat rate of the longissimus dorsi was 66.73%, the tenderness was 67.59 N, and the pH45min was 5.89, the moisture content was 66.96%, the ether extract was 11.57%, the crude protein was 20.25%, the total amino acids were 17.73%, the essential amino acids were 6.97%, and the ratio of the essential amino acids to the total amino acids was 39.33. The study indicates that Ji'an cattle have high dressing percentage and high-grade meat yield, high intramuscular fat content, low tenderness and good carcass characteristics and meat quality. [ABSTRACT FROM AUTHOR]

In recent years, a large number of light oil and gas reservoirs have been discovered in the paleogene sand sub-section of the northern belt of the Dongying Sag, and their oil and gas phase characteristics and reservoir formation patterns still lack in-depth understanding. Through the study of oil and gas geochemistry, fluid inclusion, and burial history-thermal evolution history, combined with crude oil cracking experimental products and oil and gas PPT simulation in the deep reservoir of the four lower sub-sections of sand, the deep oil and gas genesis, phase evolution and reservoir formation mode in this area are discussed. The results show that with the increase of the degree of cracking of crude oil, the critical condensation temperature gradually decreases. At higher pressures (20 MPa), the cleavage of the heavy hydrocarbon gas group was inhibited, the molar fraction of methane in the fluid composition decreased, and the critical condensation pressure of the fluid envelope decreased with nonlinear fluctuations. The characteristics of natural gas composition and carbon isotope show that the mirror plastoid reflectivity (R) of natural gas maturity parameter is between 0.9% and 1.5%, and the natural gas samples detected are the mixed causes of crude oil cracking gas and kerogen degradation gas. The absolute content of amantane and steroid detected in crude oil indicates that the deep crude oil samples detected are in a highly mature state, but are still in the early stages of cracking, and the crude oil cracking gas is moved upwards by the off-site crude oil cracking of the deep depression. The simulation of burial history, thermal evolution history and the uniform temperature of fluid inclusions in the reservoir show that there are mainly two stages of oil and gas injection in the sub-reservoir of the FS2 wellsha four sub-sections, namely crude oil (including kerogen degradation gas) charge at the end of the sand three-stage sedimentation stage and crude oil cracking gas injection from the deep reservoir in the early sedimentation of the Minghua Formation. Late high-maturity crude oil crack gas filling caused evaporative fractionation and gas washing, which was an important reason for the formation of deep light reservoirs in the region, and eventually secondary unsaturated condensate gas reservoirs and volatile reservoirs were formed [ABSTRACT FROM AUTHOR]

To explore the clinical value of hierarchical and multi-point suspension technique during laparoscopic pyeloplasty ( LP ) for children with congenital ureteropelvic junction obstruclion ( UPJO ) . Methods Taking 138 children with UPJO as the resrch object who received LP treatment in Qilu Hospital of Shandeng University from March 2017 to Decembe1· 2020. The hierarchical and multi-point suspension technique wa5 applied. There were 114 boys and 24 girls with an average age of 34. 8 ( 1 - 168 ) month. The lesion side was left ( n = 98) and right ( n = 40). Postoperative ultrasonic follow-ups were performed for outcome evaluations. Results All operations were successful. Average opera Live duration was ( 108. 5 ± 27. 7) min, intraoperative anastomotic time ( 40. 1 ± 6. 2 ) min, volume of blood loss ( 5 - 25) ml and average postoperative hospitalization stay 5. 9 days. Four cases of postoperative urinary infection improved after susceptible anti-inflammatory treatment based upon the results of urine culture. One child of lymphatic leakage improved after delayed removal of abdominal drainage tube and symplomatic supports. For two cases of hematuria,symptoms disappeared after removal of double J stent. During a follow-up period of 6 to 12 months, clinical symptoms disappeared and ultrasonic re-examination revealed that hydronephrosis disappeared or decreased, and renal cortex thickened to varying degrees. Conclusion During laparoscopic pyeloplasty, application of hierarchical and multi-point suspension technique offers a better operative field and a satisfactory outcome. IL can effectively lower the difficulty of suturing and significantly shorten operative duration. And beginners may master it quickly and easily. [ABSTRACT FROM AUTHOR]

Objective To investigate the apoptotic effect of petasin on myeloma RPMI 8226 cells and the mechanisms. Methods The inhibition of petasin on the proliferation of myeloma RPMI 8226 cells was tested by trypan blue assay. Apoptosis of RPMI 8226 cells was measured by terminal-deoxynueleotidyl transferase mediated dUTP nick end labeling (TUNEL) assay and Hoechst 33258 staining assay. Effects of petasin on caspase-3, 8 and 9 expressions, phosphorylation of ERK1/2, MEK(p-ERK1/2; p-MEK) and p38MAPK(p-p38MAPK) protein were analyzed by Western blot. Results Incubation by petasin for 24h, 48h or 72h could significantly inhibit the proliferation of myeloma RPMI 8226 cells (P<0.01, P<0.01, P<0.01). Petasin induced the apoptosis of myeloma RPMI 8226 cells in time- and concentration-dependent manners (P<0.05, P<0.05). Caspase inhibitor pretreatment could significantly inhibit the apoptosis of myeloma cells. After cultured with petasin for 72h, the expressions of caspase-3, 8 and 9 were obviously enhanced (P<0.05, P<0.01, P<0.05) and phosphorylation of p-p38MAPK of RPMI8226 cells was significantly increased (P<0.01). However, phosphorylation of p-ERK1/2 and p-MEK was decreased significantly (P<0.01, P<0.05). Conclusion Petasin can inhibit the proliferation of myeloma RPMI 8226 cells and induce apoptosis. The mechanism may be related to the activation of caspase-3, 8 and 9 proteins and the changes in phosphorylation of p38MAPK, ERK1/2 and MEK. [ABSTRACT FROM AUTHOR]

Objective: To summarize clinical experience of red man syndrome in anti-infective therapy after cardiac surgery. Methods: The data of red man syndrome in anti-infective therapy after cardiac surgery from January 2013 to August 2020 were retrospectively collected from Nanjing Drum Tower Hospital for study. Clinical characteristics and factors influencing the occurrence of red man syndrome were analyzed. Results: In anti-infecive therapy after cardiac surgery, there were totally 6 patients with red man syndrome, of whom 4 developed the syndrome during the treatment course of vancomycin or after application of the drug, one developed the syndrome induced by teicoplanin after using the drug for 23 days and 5 days after drug withdrawal, and one occurred following application of cephalosporins for 13 days. With effective treatment, all the 6 patients recovered and were discharged from hospital. Conclusion: Red man syndrome is quite common in the process of anti-infective therapy after cardiac surgery, which is mostly caused by vancomycin allergy. Early manifestations are local red rash, papule or maculopapular rash, with itching. If not actively treated, rash can spread to all parts of the body, or even cause shock with critical conditions. Early attention and active salvage measures could help patients to be out of danger. [ABSTRACT FROM AUTHOR]

Based on the lattice Boltzmann method, the numerical simulation of droplet impacting on orifice plates with different wettabilities was carried out. The effects of the Weber number (We), the wettability of the orifice surface and the orifice size on different states of droplets passing through orifice plates during impacts were studied. The numerical simulation results show that, different phenomena will occur in the processes of droplets impacting on the orifice plates. If the orifice plate is hydrophilic, the droplet will not detach from the orifice plate surface, but adhere to the lower surface of the orifice plate for a relatively low We number, and then the droplet will rise for a certain distance in the orifice channel under the action of capillarity, forming the liquid plugging phenomenon. For relatively high We numbers, droplets will pass through the orifice plates and rupture will occur. If the orifice plate is hydrophobic, the droplet will not pass through the orifice plate and migrate to the lower surface for a relatively low We number, and will finally stabilize in the orifice channel. For higher We numbers, droplets will pass through the orifice plates, and then break up, leaving droplet remains on the surfaces of the orifice plates. For various orifice sizes, the droplet will be more difficult to pass through the plate for a smaller orifice size or a lager orifice plate thickness. [ABSTRACT FROM AUTHOR]

Objective　To investigate the effect of bronchoscopic alveolar lavage on the maintenance of borderline donor lung in brain death. Methods　The brain death patients meeting the inclusion criteria and admitted to Ganmei Hospital of Kunming Medical University from September 2017 to December 2019 were randomly divided into the fiberoptic bronchoscopy alveolar lavage group （experimental group) and the control group on the basis of routine maintenance. Statistical analysis was carried out through the comparison of chest film, arterial blood gas (oxygenation index）, fiberoptic bronchoscopy and other indexes between the two groups. Result　The scores of oxygenation index, chest radiograph and fiberbronchoscope performance of the two groups after the experiment were all lower than those before the experiment the differences were statistically significant （P < 0.05）, and there was statistically significant difference in effective rate between the two groups (P < 0.05) . The effective rate of the experimental group was higher than that of the control group. Conclusion　Fiberbronchoscope alveolar lavage can be used as an effective technique to maintain the donor lung and has a wide application prospect. [ABSTRACT FROM AUTHOR]

Objective: To analyze the efficacy and safety of percutaneous microwave coagulation therapy on the recurrent liver cancer nearby the great vessels. Methods: 80 cases of patients with recurrent liver cancer nearby the intrahepatic great vessels (hepatic veins, hepatic arteries and portal vein and inferior vena cava) who were treated in our hospital from January 2011 to December 2015 were selected and randomly divided into observation group and control group. The patients in observation group received percutaneous microwave coagulation therapy, and the patients in control group underwent remove surgery. AFP, ultrasound were examined before and after the treatment, and the postoperative complications were observed. Results: In observation group after treatment, AFP level was obviously reduced, even turned to negative in some cases and the effective ratewas 92.5%, higher than that of control group (85.9%) with statistical significance (P<0.05). In the observation group after treatment, the tumor stopped growth in 15 cases, and the tumor sizewas reduced in 21 cases, and there were 4 cases with the intrahepatic metastasis tumor or expansion; in control group, the tumor stopped growth in 14 cases, and the tumor size was reduced in 19 cases, and 7 cases were ineffective. The efficacy to control the tumor size in observation group was obviously higher than that of the control group (P<0.05); and the complication rate of observation group was 22.5 % (9/40), significantly lower than 35.0 % of the control group (14/40) (P<0.05). Conclusions: Percutaneous microwave coagulation therapy is safe and effective in the treatment of recurrent liver cancer nearby hepatic veins, hepatic arteries and portal vein and inferior vena cava, so it can be used for clinical treatment of patients with recurrent liver cancer intrahepatic vessels. [ABSTRACT FROM AUTHOR]

In order to improve the global search ability and local development ability of the Sparrow Search Algorithm, Coyote Genetic Sparrow Search Algorithm (CGSSA) is proposed for the shortcomings of low optimization performance and insufficient diversity. The number of predictors in the optimization process is dynamically set by linear differential decline method. Then the selection factor is set after the algorithm update process, and a certain number of poor individuals in the algorithm are mutated according to the law of shock attenuation, and the individuals before and after the mutation are selected. The experimental results show that the CGSSA algorithm not only has better optimization performance in terms of convergence speed, search accuracy and stability, but also has better classification and robustness when it is combined with the BP neural network and applied to the classification task in machine learning. [ABSTRACT FROM AUTHOR]

Phyllanthus acidus, an evergreen shrub or tree in Euphorbiaceae, is mainly distributed in Thailand, Vietnam, Myanmar, Laos, etc. It is also introduced and cultivated in Xishuangbanna and Yuanjiang areas of Yunnan Province, China. The fruits are edible and the plant has been widely used to treat various diseases, such as hypertension, asthma, diabetes, dermatitis, fever, smallpox, and so on, by the local people of its growing areas. Moreover, the young leaves are utilized as edible vegetables in Indonesia, Thailand and India. Phytochemical studies yielded sesquiterpenes, diterpenes and triterpenes from roots and stems, and flavonoids as the major chemical constituents from the leaves. Some constituents showed obvious anti-hepatitis B virus(HBV), anti-bacterial, anti-inflammatory, hepatoprotective and anti-hypertensive activities. For example, parts of the norbisabolane sesquiterpenes displayed potential anti-HBV activities, with IC50 values of 0.8-36 μmol·L-1 against HBV surface antigen(HBsAg)and HBV excreted antigen(HBeAg), and the results indicate that the ketal group at C-5 and sugar moieties at C-13 play important roles in the selectivity of HBsAg and HBeAg. This paper reviews the research progress of chemical constituents and pharmacological activities of the plant from 1966 to 2020, which provides scientific evidence and reference for its future study, spread, application and development. [ABSTRACT FROM AUTHOR]

目的 了解肥胖相关指标及胰岛素抵抗相关的代谢紊乱之间的关系。 方法 选取1965年出生、长期居留镇江市、2012年4~10月参加该院健康体检的成年人共461人（其中男237人，女224人），测量其身高、体质量、颈围、腰围、臀围、腰臀比（WHR）、BMI、血脂、空腹和餐后2小时胰岛素、空腹和餐后2小时血糖及其他相关指标，并进行相关性分析。 结果 颈围与WHR、腰围及BMI呈显著正相关（男：r=0.412、0.717、0.691，女：r=0.389、0.591、0.643，P<0.01）。颈围、WHR、腰围及BMI等肥胖相关指标的增高趋势分别与高血压、血脂异常、糖耐量异常及高胰岛素血症的增高趋势相吻合，且无性别差异，随着颈围的增加，上述疾病的发生率也相应增加。 结论 颈围与肥胖相关指标及胰岛素抵抗相关的代谢紊乱有关。颈围测量可作为中心性肥胖的有效测量指标及临床胰岛素抵抗相关的代谢紊乱的有效筛查指标。 [ABSTRACT FROM AUTHOR]

Objective To compare the clinical effectiveness and the improvement of mental behavior in children of adenoid hypertrophy with the two different operation approaches．Methods 120 children were randomized into control group （60 cases） and trial group （60 cases）．The control group received traditional adenoidectomy while the trial group received nasal endoscopic-assisted transoral adenoidectomy．We compared clinical symptoms of nasal obstruction，rhinorrhea，night snore，acouesthesia in the two groups after operation 3 months．We also compared the improvement of mental behavior in children between preoperative and postoperative 3 months．Results The main clinical symptoms were improved obviously in the two groups 3 months after operation．The trial group was better than the control group （P＜0.05）．The abnormal behavior detection rate and total coarse points in the two groups 3 months after operation were significantly lower than preoperation. There was significant difference between the two groups （P ＜0.05）．Conclusion Nasal endoscopic-assisted transoral adenoidectomy is an ideal way to cure adenoid hypertrophy in children, thereby worthy of further promotion and application. [ABSTRACT FROM AUTHOR]

Objective To analyze the efficacy and safety of apatinib in extensive-stage small cell lung cancer (ES-SCLC), and to provide a reference for the clinical treatment of ES SCLC. Methods Twenty-two patients with advanced ES-SCLC admitted to the hospital from September 2015 to February 2018 were selected as the research subjects. 12 first-line patients received apatinib combined with chemotherapy and apatinib single-agent maintenance treatment after chemotherapy. 10 patients and above were treated with apatinib monotherapy, 21 days of treatment was one cycle, and the full analysis set included all patients who had been treated for at least one cycle. Observation and analysis of 22 patients' medication status, efficacy, death, and occurrence of adverse drug reactions. The primary endpoint of treatment is the objective response rate, and the secondary endpoints are progression-free survival (PFS), disease control rate, overall survival (OS) and treatment safety. Results The median OS of 22 patients was 11.1 months, and the median PFS was 5.6 months. Among the 22 patients, 1 case was complete remission, 9 cases were partial remission, 8 cases were stable, and 4 cases progressed: occurred in 22 patients. There were 14 cases (63.6%) of various types of adverse reactions, 5 cases (22.7%) of grade ≥||. The main types of adverse reactions were hand-foot skin reactions, hypertension, and proteinuria. The common adverse reactions of grade ≥ were hypertension and hand-foot skin. reaction. Conclusion Choosing apatinib as the first-line and maintenance treatment of ES-SCLC has good safety, obvious overall curative effect, and has the value of promotion and application. [ABSTRACT FROM AUTHOR]

To solve the problems that the blur in the mosaic image and the ghosting appears after motion image mosaic. In the stage of image registration, the method used the perceptual hash similarity metric to select the weight ωi,j with the best transformation effect for calculating the local projection transformation matrix. Then, it used the frame difference method and the region growing algorithm to segment the moving object. The difference region is single sampled while the other regions were linear weighted fusion. Finally, this paper constructed a special aerial images dataset for image mosaic and conducted experiments based on it. The experimental results show that the proposed method requires low extra computation time and effectively suppress the blur and image abnormality in overlapping area, eliminate ghosting of images with moving objects, which significantly improve the quality of UAV’s aerial image mosaic. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of compound Houtou capsule combined with teprenone on gastrointestinal hormones, inflammatory factors and expression of transforming growth factor-β(TGF-β) and Smad3 in patients with gastric ulcer. Methods: 120 patients with gastric ulcer who were treated in our hospital from January 2017 to January 2020 were selected. According to the method of envelope lottery, they were randomly divided into observation group and control group with 60 cases in each group. Both groups were given esomeprazole orally. On this basis, the control group was treated with tepreidone, and the observation group was given compound Houtou capsule combined with teprenone. The changes of gastrointestinal hormones, inflammatory factors and the expression of TGF-β and Smad3 in gastric antral mucosa of the two groups were observed before and after treatment. The ulcer healing, adverse reaction rate and recurrence rate were compared between the two groups. Results: The total effective rate of ulcer healing of the observation group were significantly higher than those of the control group, the difference was statistically significant (P<0.05). After treatment, the levels of motilin (MTL), gastrin (GAS), C-reactive protein (CRP), interleukin-6 (IL-6) and interleukin-8 (IL-8) of the two groups were all lower than those before treatment, and the levels of the above indicators of the observation group were lower than those of the control group (P<0.05). After treatment, the expression levels of TGF-β and Smad3 of the two groups were decreased compared with those before treatment (P<0.05), and the expressions of TGF-β and Smad3 of the observation group were lower than those of the control group (P<0.05). The recurrence rate of the observation group was significantly lower than that of the control group (P<0.05), but there was no significant difference in the incidence rate of adverse reactions between the two groups (P>0.05). Conclusion: Compound Houtou capsule combined with teprenone can significantly improve the levels of gastrointestinal hormones and inflammatory factors in patients with gastric ulcer, reduce the expression of TGF-β and Smad3 in gastric antral mucosa, promote ulcer healing, and have good safety and low recurrence rate. [ABSTRACT FROM AUTHOR]

Objective To explore the relationship between insulin resistance, glucose and lipid metabolism related molecules and colorectal polyps. Methods A total of 262 healthy people who underwent colonoscopy in Shandong cancer hospital from June 2019 to September 2020 were selected. The levels of serum vascular cell adhesion molecule-1 (VCAM-1), fibroblast growth factor 19 (FGF19), insulin like growth factor (IGF-1), fasting blood glucose and fasting blood insulin were detected by enzyme-linked immunosorbent assay (ELISA). Insulin resistance index (HOMA-IR) was calculated, and the influencing factors of occurrence, pathological type, size and number of polyps were analyzed. Results Among 262 cases, 116 cases were polyp free, 113 cases were adenomatous polyp and 33 cases were inflammatory polyp. HOMA-IR, VCAM-1 and FGF19 in polyp group were 2.904±1.754, (334.415±139.573) ng/ ml and (135.865± 98.470) pg/ ml, respectively, which were higher than 2. 369 ± 1. 306, (302.480± 99. 946) ng/ ml and (110.694±76.044) ng/ ml in non-polyp group, respectively (P < 0.05). Multivariate Logistic regression analysis showed that the gender (OR =4.269, 95%CI: 1.963-9.405) and FGF19 (77.0-131.4 pg/ ml: OR = 2.385, 95%CI: 1.155-4.926) were independent factors of colorectal polyps. The gender (OR =3.799, 95% CI: 1.650-8.748) and FGF19 (77.0-131.4 pg/ ml: OR = 2.290, 95%CI: 1.072-4.891) were independent factors of colorectal adenomatous polyps. The gender(OR = 6.725, 95% CI: 1.853-24.410) and fasting plasma glucose (=6.5 mmol/ L: OR =0.047, 95%CI: 0.009-0.245) were independent factors of colorectal inflammatory polyps. The gender (OR = 3.539, 95% CI: 1.293-9.689) was an independent factor for the occurrence of single polyp. The gender (OR =5.063, 95% CI: 2.048-12.515), FGF19 (77.0-131.4 pg/ ml: OR =2.502, 95%CI: 1.102-5.681), fasting plasma glucose (=6.5 mmol/ L: OR = 0.282, 95%CI: 0.095- 0.839) were independent factors of multiple polyps. The gender (OR =3.416, 95% CI: 1.134-10.289) and fasting insulin (=9.4 µU/ ml: OR = 9.480, 95% CI: 1.485-60.521) were independent risk factors for colorectal polyps<0.5 cm. The gender (OR=3.151, 95%CI: 1.244-7.984) and fasting plasma glucose (=6.5 mmol/ L: OR =0.310, 95%CI: 0.102-0.941) were independent risk factors for colorectal polyps with the size of 0.5-0.9 cm. The gender (OR =22.649, 95%CI: 4.154-123.485), age (55 to 64 years old: OR = 4.473, 95%CI: 1.070-18.704; =65 years old: OR = 5.815, 95%CI: 1.300-26.009), BMI (=28 kg/ m2: OR = 5.310, 95%CI: 1.224-23.032) and FGF19 (77.0-131.4 pg/ ml: OR =7.474, 95%CI: 1.903-29.351) were independent factors for colorectal polyps with size = 1.0 cm. Gender stratification analysis showed that FGF19 was an independent factor for the occurrence of male polyps (77.0-131.4 pg/ ml: OR =6.109, 95%CI: 1.688-22.104) and adenomas (77.0-131.4 pg/ ml: OR =6.401, 95%CI: 1.717-23.864). The age (55 to 64 years old: OR = 3.783, 95%CI: 1.052-13.611) and VCAM-1 (=352.8 ng/ ml: OR = 4.341, 95%CI: 1.142-16.493) were independent risk factors of female polyps. The age (55 to 64 years old: OR = 5.743, 95%CI: 1.205-27.362, =65 years old: OR =6.885, 95%CI: 1.143-41.467), VCAM-1 (=352.8 ng/ ml: OR =6.313, 95%CI: 1.415-28.159) and IGF-1 (=7.6 ng/ ml: OR = 5.621, 95%CI: 1.069-29.543) were independent factors of female adenoma. Conclusions The occurrences of colorectal polyps and adenomatous polyps are related to insulin resistance and glucose and lipid metabolism. Serum FGF19 is an independent influencing factor for the occurrence of colorectal polyps and adenomatous polyps, and is a potential serological diagnostic marker and therapeutic target for colorectal polyps and adenomatous polyps. [ABSTRACT FROM AUTHOR]

Lithium niobate crystals have many physical properties, such as nonlinear effect, electro-optic effect, acousto-optic effect, photorefractive effect, piezoelectric effect, and pyroelectric effect, et al. They have been widely used in surface acoustic wave (SAW) device, electro-optic device, acousto-optic device, and so on. After over 60 years of development, lithium niobate single crystal is still active in the material science and application. With the continuous development of material properties, plenty of new functions, new devices, and new applications come out. Especially in recent years, the development of lithium niobate single crystal films provides a key material for the new generation of information and communication technology in the aspects of thin film filter and integrated electro-optic modulation. In this review paper, the growth of lithium niobate crystals, the preparation of crystal films, and the new applications of lithium niobate crystals in recent years are briefly reviewed, and the prospective application of lithium niobate crystals is discussed. [ABSTRACT FROM AUTHOR]

There were many terms with different meanings to refer to menstruation in ancient books on Chinese medicine. To sort out the changes in the names of menstruation and their connotations is very important for correct understanding of the theoretical connotations of menstruation in medical literature. This article reviews a wide range of literature ranging form the four major TCM classics to important literature related to TCM gynecology in the Ming and Qing dynasties, collects and summarizes the names and interpretations of menstruation, and identifies four different theoretical connotations of the names of menstruation in different literature. Some names describe the phenomenon of uterine bleeding, some emphasize the periodic physiological phenomena of uterine bleeding, some refer solely to the blood discharged during menstruation and others mean the fine substances that run in the body to nourish the body. [ABSTRACT FROM AUTHOR]

To study the dissipation rate and the final residue level of fluazinam in wax gourd, the dissipation dynamics and final residue trials of 500 g/L SC were carried out in Beijing, Shandong, Anhui, Hunan, Yunnan and Guangdong Provinces. Among them, dissipation dynamic trials were set up in Beijing and Anhui. Samples were extracted with acetonitrile, cleaned up by primary secondary amine (PSA), detected by ultra performance liquid chromatography-tandem mass spectrometry(UPLCMS/MS), and quantified by external standard method. The results showed that, among the spiked levels of 0.01-1 mg/kg, the recoveries ranged from 89% to 109%, the relative standard deviations (RSDs) ranged from 2.8% to 12%, and the limit of quantification (LOQ) was 0.01 mg/kg. The half-lives of fluazinam on wax gourd were between 2.04 to 2.17 days in Beijing and Anhui, respectively. The final residue trials in six provinces showed that the residue level of fluazinam on wax gourd was between

Objective To investigate the relationship between total prostate specific antigen (TPSA), free prostate specific antigen/total prostate specific antigen [RAT(FIT)], Gleason score, other factors and the whole-body bone phme imaging which was used to evaluate the bone metastasis of prostate cancer (PCa), and the diagnostic value of the abnormal concentration of bone imaging agent for single lesion. Methods A retrospective analysis of 99Tc100 -methylene diphosphonate (99Tc100-MOP) whole-body bone imaging data of 93 patients with confirmed PCa in The First Hospital of Shanxi Medical University from Jan 2018 to Jan 2019 was conducted. The hone metastasis was diagnosed by whole-body bone imaging. The factors related to PCa bone metastasis, including age, TPSA, RAT (FIT), Gleason score were analysed by Chi-square test and logstic two-class regression. The optimal cut-off point of TPSA was defined by receiver operating characteristic (ROC) curve. The region of interest (ROI) Techni clue was used to repeatedly delineate the lesion (T) and the background area (NT) outside the bone and calculate the abnormal concentration value of bone imaging agent (T-NT)INT, and the ROC curve was used to determine its diagnostic value. Results The result of Chi-square analysis showed that Gleason score, TPSA and RAT (F/T) were associated with hone metastasis (P<0.05). Logistic regression analysis showed that TPSA and RAT (F/T) were associated with hone metastasis (P<0.01). TPSA >92.82 ng/ml was the best diagnosis for bone metastasis, and the sensitivity and specificity were 77.1%. and 81.0%, respectively. There were 320 sites of high concentration of imaging agents in the whole-body bone imaging of PCa patients (194 in the metastatic group and 126 in the non-metastasis group). The (T-NT)/NT in the hone metastasis group was 7111±0.29, the non-bone metastasis group was 2.69±0.20. (T-NT)/Nf >3.52 was the best diagnosis for bone metastasis of single lesion, and the sensitivity and specificity were 86.1% and 80.2%, respectively. Conclusions Gleason score, RAT (FIT) and TPSA arc important risk factors of PCa hone metastasis. TPSA >92.82 ng/ml is the most supportive diagnosis for PCa bone metastasis. The abnormal concentration of bone imaging agent >3.52 owns the best diagnosis effect for the single lesion of PCa. [ABSTRACT FROM AUTHOR]

The traditional research paradigms based on digitalization and full-text retrieval are not sufficient for history, philology and linguistic studies within the paradigm of digital humanities. For quantitative analysis and visualization, the words, time, places, persons and events in the ancient texts need to be constructed into a historical digital database. By applying the natural language processing technology of ancient Chinese, the word segmentation, parts-of-speech, time, person ID, location ID and GIS information are annotated with manual checking. Thus, the Zuozhuan digital humanity knowledgebase is constructed. Then the key persons, social networks, personal traveling tracks and distances in Zuozhuan are calculated, which may propose new methods to related ancient texts annotation, structural humanity knowledge base construction in history and philology research. Finally, the potential improvements and applications of the database are discussed furthermore. [ABSTRACT FROM AUTHOR]

Objective ： To validate and evaluate the accuracy of the four warfarin stable -dosage prediction models in the pa¬tients with valve surgery .Methods ： A total of 266 patients with maintenance dosage after oral administration of warfarin were selected as study subjects .The CYP2 C9 and VKORC1 gene polymorphisms were detected by gene chips .The predicted dosages of warfarin were calculated by IWPC model >Gage model,guideline model and Tan model ,and the accuracy of each model was validated and evaluated .Results: Except for the Tan model，the difference between the predicted dosages of the three models and the actual maintenance dosage was statistically significant ( P<0 .05 ) .The Tan model could predict accurate dosages for 46 .2% of the patients ,with a relatively good linear relationship (r2=0 .276 ) and minimal absolute deviation (MAD - 0 .0 ) .The results of the group study showed that the prediction accuracy of each model in the low dosage group was relatively poorer .The predic¬ted dosage of the guideline model and the Tan model were best fit with the actual dosage in the medium dosage group .For the high-dosage group，the IWPC model was more accurate than other models .Conclusion: Not considering valve surgery，the cur¬rently-used warfarin dosage prediction models were not so accurate in the patients with early heart valve surgery .Heart valve surgery could have a significant impact on the use of warfarin dosage .For those patients after heart valve surgery，it was better to use the dosage prediction model established on the basis of the population with the same features. [ABSTRACT FROM AUTHOR]

BACKGROUND: There are abundant rare earth elements in Hetian jade. The accurate determination of the content of rare earth elements is of great significance for revealing the source of ore-forming materials, the nature of ore-forming fluids and the genesis of the deposit. OBJECTIVES: To compare the different acid systems in microware digestion and investigate the elimination test of polyatomic interferences, so as to develop a method for the determination of REE in Hetian jade by inductively coupled plasma-mass spectrometry（ICP-MS） with microwave digestion.METHODS: After comparing the efficiency of HNO3-HF acid dissolution and Li2B4O7-LiBO2 fusion, the Hetian jade samples were digested by HNO3-HF. Fifteen rare earth elements were determined by ICP-MS. 103Rh and 49In are used as internal isotopes to complement matrix effect and correct sensitivity drift, in order to reduce matrix effect. RESULTS: The detection limits of the method were 0.0008-0.0091μg/L, whereas the recoveries were 101.0%-120.0%. The relative standard deviation was 0.55%-1.83%（n=11）.CONCLUSIONS: This method uses less acid and has a low blank value. It is applied to the analysis of Hetian jade in different regions. The distribution pattern of rare earth elements is characterized by right-inclined light rare earth enrichment, which provides constraints on the genesis of the jade deposit. [ABSTRACT FROM AUTHOR]

[Objective】The present paper aimed to study the effects of different moisture treatments on soil water and salt changes and yield of mechanically harvested cotton during boll stage. ' Method (The experimental plot was used in the key laboratory test base of modem water¬saving irrigation corpus of Shihezi university and the water-saving irrigation test station of Shihezi university. Three water gradients were set up by pit test method, and each treatment was repeated three times. At the end of each growth period, the indexes of soil water content, soil salt content and yield were determined, and the effects of diferent water treatments on soil water and salt change and yield of mechanically har¬ vested cotton were analyzed. ' Result】 The results showed that in W2 (the lower limit of bud period was 60 ' , the lower limit of flowering and boiling period was 70 ' ), the water holding capacity of 0 - 60 cmsoil layer in the root layer of water treatment could reach 63. 28 ', which was suitable for crop growth. The range and the salt leaching effect were ideal, forming a desalting desalination zone, and the cotton field yield wa 5482.38 kghm2 , which wa 12.07 ' -30.39 ' higher than otlier treatments, and the water use efficiency wa 1.30 kgm3, which wa also the best. ' Conclusion 】The effects of different water treatments on the change of water and salt and cotton yield were significant, water treatment of W2 (lower limit of bud stage was 60 lower limit of flowering and boll stage was 70 ') was a more reasonable water control strategy [ABSTRACT FROM AUTHOR]

Objective: Establishment and application of reverse transcription-polymerase spiral reaction (RT-PSR) for rapid detection of Mycobacterium tuberculosis (MTB). Methods: The RT-PSR specific primers were designed by the 16S rRNA gene of M. tuberculosis and preliminary establishment of MTB amplification technology by optimizing the reaction conditions. Subsequently, the specificity and sensitivity of RT-PSR, RT-LAMP and real-time PCR method were tested with 2 strains of MTB and 11 other pathogenic bacteria. The diagnostic comparison of sputum samples from 83 tuberculosis patients by RT-PSR, Lowenstein-Jensen culture, RT-LAMP and real-time PCR method. Result (s): The RT-PSR method for MTB detection was successfully established and optimized. Compared with RT-LAMP method, the specificity of both methods was 100%. The sensitivity of RT-PSR was 1 CFU/mL, which was 10 times higher than that of real-time PCR and the detection limit was 0.1 pg/mL. The results of clinical samples showed that the positive rates of RT-PSR and RT-LAMP method were 98.80% (P<0.05) and 96.39% (P<0.05), and the difference was statistically significant when compared with Lowenstein-Jensen culture method. Conclusion (s): Compared with the traditional detection method, the RT-PSR method show good specificity and sensitivity for the diagnosis of MTB in clinical samples, which is suitable for the promotion and application of MTB prevention and treatment in primary medical units [ABSTRACT FROM AUTHOR]

Aiming at the problem that the existing target detection framework based on big data and deep learning is difficult to realize real-time video target detection on low-power mobile and embedded devices, this paper improved the target detection framework SSD based on deep learning, and put forward an improved multi-target detection framework LSTM-SSD which was dedicated to multi-target detection of traffic scenes video. Combining single image detection frame with recursive neural network LSTM network to form an interleaved circular convolution structure, it realized the temporal association of network framelevel information by extracting the feature map between propagation frames by adopting a Bottleneck-LSTM layer, which greatly reduced the network calculation cost. Combining the time-aware information with the improved dynamic Kalman filtering algorithm, the tracking and identification of the targets which were influenced by strong interference such as light change and largearea occlusion in the video could be realized. Experimental results show that the improved LSTM-SSD can achieve good results when dealing with the difficult detection situations such as multi-targets, cluttered background, light changes, fuzziness and large-area occlusion. Compared with other target detection frameworks based on deep learning, the average accuracy rate of all kinds of target identification is increased by 5% - 16%, the average accuracy rate is increased by 4% - 10%, the multi-target detection rate is increased by 4% - 19%, and the detection frame rate reaches 43 fps, basically meeting the requirements of real-time . The balance between the accuracy of the algorithm and the running speed is achieved, and a good detection and identification effect is achieved. [ABSTRACT FROM AUTHOR]

Objective To evaluate the efficacy and safety of high-frequency repetitive transcranial magnetic stimulation(rTMS) over left dorsolateral prefrontal cortex(DLPFC) for the treatment of minimally consciousness state(MCS) due to traumatic brain injury(TBI). Methods From December 2015 to September 2016, 32 MCS patients due to TBI were admitted to the department of neurosurgery, the Seventh Medical Center of PLA General Hospital. They were divided into transcranial magnetic stimulation treatment group and control group. The treatment group received transcranial magnetic stimulation. The control group received sham stimulation during the same period of time. The evaluation index was the change in the score of the revised coma recovery scale（CRS-R） (comparison between groups, baseline vs. treatment endpoint). ResultsThe improvement rate of consciousness in the treatment group was 64.7%, compared with 13.3% in the control group. Compared the baseline, a significant increase of CRS-R score in the treatment group was found than no significant improvement in the control group. No adverse events occurred in all cases during the treatment. ConclusionThe 10 Hz high-frequency repetitive transcranial magnetic stimulation over left dorsolateral prefrontal cortex has a definite awakening regulation effect on MCS patients due to TBI, and stimulation with this parameter is safe. [ABSTRACT FROM AUTHOR]

In order to improve the accuracy of segmentation and counting of insect images，an insect image segmentation and counting method based on convolutional neural network is proposed. Based on the U-Net model，this method constructs an insect image segmentation model named Insect-Net. After inputting the complete insect image and the split insect image into the model, the features of the two images are extracted and merged. The merged features are inputted into a 1 X 1 convolutional layer to get the final segmentation results. After the obtained results are binarized, the contour detection algorithm is used to extract the contours of the insects and count them. The experimental results show that the method has higher segmentation accuracy and counting accuracy in the detection of insects, which are 89. 2% and 94. 4% respectively. The idea of deep learning and convolutional neural network effectively improves the counting accuracy of insect images, and provides a large number of non-background datasets for insect identification classification. [ABSTRACT FROM AUTHOR]

【Objective】The present paper aimed to analyze the effect of water regulation on the growth and development of rice and irrigation water use efficiency. 【Method】Three water gradients were set at tillering stage to control water content. At the end of each growth period, the indexes were sampled and measured. 【Result】Water regulation at tillering stage had significant effect on rice growth and irrigation water use efficiency under two cultivation methods. W1 and W2 treatments had little effect on rice plant height, and W3 treatment reduced plant height seriously under water stress. Water regulation at tillering stage has obvious influence on the final tiller number, which shows that the average number of tillers under mulching cultivation is 17.44 per hole, and the average number of tillers under bare land cultivation is 17.60 per hole. W2 treatment can maintain a higher leaf area at the later growth stage, which is more conducive to the accumulation of photosynthetic products and the formation of final yield of rice. Under the condition of film mulching and bare land cultivation, the utilization rate of irrigation water of W2 treatment was the highest, which was 0.64 and 0.46 kg/m~3 respectively. 【Conclusion】Appropriate water stress at tillering stage of drip irrigation rice is beneficial to rice growth and development and then to increase yield. From the perspective of drip irrigation rice to improve irrigation water use efficiency and yield, W2 water treatment of drip irrigation rice film mulching cultivation mode can be used as a more appropriate control measure based on the experimental conditions. [ABSTRACT FROM AUTHOR]

The discharging temperature of large reservoirs with high water head has great influence to the agricultural irrigation and river water ecological environment. Analyzing the vertical distribution law of water temperature and the influence of stratified water intake to the discharging temperature can provide scientific basis for the design and regulation of reservoirs. Taking Qianping Reservoir as a research object, the water temperature calculation model was set up by the DELFT3D FLOW software. The model was used to analyze the discharged water temperature of the high-head and large reservoir in two different ways, stratified water intake and single layer water intake. The calculation model selected the ocean temperature model and collected the mean multi-year data of the surrounding weather stations as the background data. Hydrological data from four typical years in the Qianping Reservoir, ie, high flow year, normal flow year, low flow year, and especially low flow year were used as initial conditions. The upstream water inflow and downstream water intake were selected as boundary conditions. The analysis results show that the temperature of discharged water and natural water are close when adopting the stratified water intake solution, which can meet the needs of crop irrigation. [ABSTRACT FROM AUTHOR]

[Objective] The present paper aimed to study the wind erosion monitoring of grape forest land. [Method] The vineyard production area on the oasis and desert interlaced zone of Helan mountain in Ningxia was used as tested area, and field investigations and laboratory tests were used to analyze the effects of vineyard production areas on soil wind erosion by using other site types as controls. [ Result ] Through the observations of 2016 and 2017, it was shown that wind erosion mainly occurred in April-June in various site types, and the newly opened land of wind erosion grapes > 1 year grape base > 3 years grape base > grassland > 9 years grape base. In the early stage of the construection of the wine grape base and in the period of 1 year to 3 years, the amount of wind erosion was significantly greater during the spring planting of the autumn soil, which was the most serious in spring. After 8-9 years of cultivation, the protection forest was basically perfect, and the amount of wind erosion was obviously reduced. [Conclusion]The longer the construction time of the grape base was, the smaller the surface wind erosion was. At the same time, it was proposed that the tillage before the rain, the irrigation after the tillage could form the soil physical crust, and the green manure greening, Increase physical coverage and improve shelter forest systems to reduce wind erosion. [ABSTRACT FROM AUTHOR]

Aiming at the problems that the existing target detection framework based on big data and depth learning has poor recognition effect on low-resolution small targets in high-resolution complex large-field scenes, and the accuracy and real-time performance of multi-target detection are difficult to balance, this paper improved the SSD based on depth learning, and proposed an improved multi-target detection framework DRZ( dynamic region zoom-in) -SSD, which was dedicated to multi-target detection in complex large traffic scenes. It carried out the detection in a coarse -to-fine strategy. It trained a low-resolution coarse detector and a high-resolution fine detector respectively, downsampled the high-resolution image to obtain a low-resolution version, and designed a dynamic region zoom-in network based on enhanced learning. It dynamically enlarged the low-resolution small target region to a high-resolution and used the fine detector to carry out detection and identification, and detected the remaining image region by using the coarse detector, so that the detection and identification accuracy of the small target and the operation efficiency were obviously improved. It adopted fuzzy threshold method to adjust the adaptive threshold strategy to avoid adapting to the data set and improved the decision-making ability of the model and significantly reduced the detection missed alarm rate and false alarm rate. Experiments show that the improved DRZ-SSD can achieve good results when dealing with weak targets, multi-targets, cluttered background, occlusion and other difficult detection situations. Through testing on the specified data set, compared with other target detection frameworks based on deep learning, the average accuracy rate of various types of target recognition has increased by 4 % - 15%, the average accuracy rate has increased by 9% -16%, the multi-target detection rate has increased by 13% ~ 34 %, and the detection and recognition rate has reached 38 fps, realizing the balance between the accuracy of the algorithm and the running rate. [ABSTRACT FROM AUTHOR]

Objective To investigate the relationship between bone mineral density(BMD) and betatrophin in patients with type 2 diabetes mellitus(T2 DM). Methods We enrolled 95 patients with T2 DM. BMD of the lumbar vertebrae(L1-L4), femoral neck(FN), and total hip(TH) in all the patients were measured using dual energy X-ray absorptiometry. According to BMD values, subjects were divided into normal bone mass group(n=46) and abnormal bone mass group(including low bone mass and osteoporosis, n=49). Oral glucose tolerance test(OGTT) and insulin releasing test were conducted in all the patients. Serum betatrophin levels were determined with ELISA method. Results Compared with normal bone mass group, the levels of serum betatrophin in abnormal bone mass group was significantly elevated(P<0.05). Based on the correlation analysis, the levels of serum betatrophin was negatively correlated with BMD of FN and TH(r=-0.238,-0.208, respectively, all P<0.05). When subjects were divided into three subgroups from low to high betatrophin levels, there was an increase in abnormal BMD rates(38.7%, 53.1% and 62.5%). Conclusion Serum betatrophin could be an indicator in the occurrence and development of osteoporosis in patients with type 2 diabetes mellitus. [ABSTRACT FROM AUTHOR]

In order to realize automatic, universal and accurate identification and guidance of unstructured roads for unmanned equipment in the field environment, this paper proposed a road guidance algorithm for field scenes based on graph reasoning mod el and intelligent optimization. Firstly, the method segmented the image into homogeneous superpixel blocks, and fused multi-features of the superpixel blocks to construct a training set. Improved the traditional Laplace support vector machine algorithm, combined th e location information of superpixel blocks, dynamically selected superpixel seed blocks in road areas, and trained multi-class classifier regressors of superpixel blocks and consistency regressors of adjacent superpixels. Combined the regression values of two kinds of regressors, constructed the energy function of Markov random field and then used the standard graph cutting algorithm to iteratively obtain the minimized energy function to realize the initial road reasoning segmentation. Combined the initial segmentation results of roads, the objective function was constructed according to the constraints set by people's intuitive perception of roads, and used the differential immune clonal evolution algorithm to intelligently optimize and extract the guide lines of roads. The data collected in Zhushan, Nanjing and DARPA grand challenge database were tested,and it compared the results qualitatively and quantitatively with those of classical algorithms. The results show that the extraction accuracy of the guide line of unstructured roads by this algorithm in the field environment is over 91. 79%,compared with classical algorithms, the detection accuracy is increased by 48. 1 % and 35. 5% respectively,and the processing efficiency of the algorithm is increased by 98. 6 % and 97 . 8 % respectively, which balances the real-time performance and accuracy of detection and has a strong application prospect. [ABSTRACT FROM AUTHOR]

Objective: To understand the characteristics of patients who were not included in the severe mental disorder Information System in Hunan Province. Methods: Using multi-stage stratified cluster random sampling method, 89 465 persons were sampled out. Qualified trained investigators screened the participants using the General Health Questionnaire (GHQ-12) and behavioral abnormalities cue interviews, and 6082 ones with high or moderate risks based on GHQ-12 or showed possible psychiatric symptoms based on behavioral abnormalities cue interviews were interviewed by trained psychiatrists with the Structured Clinical Interview for DSM-IV and formal diagnoses were made. The 720 patients who were diagnosed as having severe mental disorders were included in this study. The personal information was cross-examined with the Information System to identify who were and who were not included in the Information System. Then demographic characteristics, social function, and clinical characteristics of the patients who were included in the System were compared with those who were not included. Results: Among 720 patients with severe mental disorders, 378 (52. 5%) were not included in the system. Unconditional logistic regression analysis showed that those who were divorced or widowed, patients from areas with lower detection rate, and those who had never sought for help were less likely to be included in the System. Conclusion: The proportion of patients with severe mental disorders included in the Information System in Hunan province needs to be improved. [ABSTRACT FROM AUTHOR]

Objective To observe the changes of renal activity and 11 intercostal space in 80 patients with non-renal diseases in lateral position and prone position by ultrasonography, and to explore the anatomical theoretical basis for the selection of ultrasound guided percutaneous lithotripsy (PCNL) in lateral position. Methods Eighty patients with non-renal diseases underwent ultrasonic examination of the kidney in the prone position (the examinee lies prone, a pillow with a width of50 cm and a height of 10 cm is added to the upper abdomen) and the lateral position (the examinee lies on the side and we adds a pillow at the waist, the pillow specification is the same as the above). Point tracking technology and measurement software attached to the ultrasonic system were used to measure the degree of kidney movement in the lateral and prone positions, the distance of the kidney moving downward when the prone position was changed to the lateral position, the distance from the calyx to the body surface in the posterior group, and the 11 intercostal space. Results In the lateral position, the up and down mobility of the left kidney was (13.7 ±3.0) mm, the left and right mobility was (1.5 ± 0.4) mm, and the front and rear mobility was (1.7 ±0.4) mm, while in the prone position, the up and down mobility of the left kidney was (8. 6 ±2.0) mm, left and right mobility was (1.2 ± 0.2) mm, and the front and rear mobility was (1.2 ±0.3) mm, with statistically significant difference, all P <0.05. In the lateral position, the up and down mobility of the right kidney was (13.9 ±3. 7) mm, the left and right mobility was (1.5 ±0.4) mm, and the front and rear mobility was (1.7 ±0.3) mm; in the prone position, the up and down mobility of the right kidney was (8. 6 ± 2. 5 ) mm, the left and right mobility was (1.2 ±0.2) mm, and the front and rear mobility was (1.2 ±0.2) mm, with statistically significant difference, all P<0.05. When the prone position was changed to the lateral position, the distance of the left kidney descending was (19. 8 ±3. 3 ) mm, and the distance of the right kidney descending was (17. 7 ±4. 2) mm, respectively, with statistically significant difference, P <0.05. The distance from the calyx to the body surface of the left posterior renal group was (60.1 ±13.7) mm, and that of the right posterior renal group was (59.7 ±12.9) mm in the lateral position. The distance from the calyx to the body surface of the left posterior renal group was (54. 0 ± 11.3) mm and that of the right posterior renal group was (55. 3 ± 11.5) mm in the right posterior renal group in the prone position, with statistically significant difference, all P <0.05. In the lateral position, the left side of the 11 intercostal space was (23. 9 ± 1. 1 ) mm and the right side was (24.4 ±1.6) mm; in the prone position, the left side of the 11 intercostal space was (22.4 ±0.6) mm and the right side was (22.2 ±0.9) mm, with statistically significant difference, all P <0.05. Conclusions Compared with the prone position, the lateral position shows increased renal mobility, decreased renal position, increased 1 1 intercostal space, and increased distance from the calyces to the body surface in the lateral position. Ultrasound-guided PCNL in the lateral position can improve the safety and reduce the difficulty of operation. [ABSTRACT FROM AUTHOR]

Objective To analyze the risk factors associated with intracranial infection after craniocerebral surgery, and to provide evidence for reducing intracranial infection after craniocerebral surgery. Methods The literatures related to intracranial infections after craniocerebral surgery included in Web of Science, PubMed, Scopuss, Karger, EBSCO+ Medline, Embase, China Knowledge Network, Wanfang, and Weipu Database were retrieved. The search time was from 2009 to 2018. The literature was evaluated using the Newcastle-Ottawa Scale(NOS)scale and the data was analyzed using STATA12. 0. Results Thirty eligible studies were eventually included in a total of 36 773 patients. The analysis showed that risk factors for intracranial infection after craniocerebral surgery included incision type, secondary surgery, postoperative GCS score, postoperative cerebrospinal fluid leakage, operative time, and intraoperative indwelling drainage. Age, diabetes, preventive use of antibiotics, surgical sites, and emergency surgery were not associated with intracranial infection. Perioperative use of hormones and intracranial infections after craniocerebral surgery were controversial. Conclusion Avoiding reoperation, cerebrospinal fluid leakage, unnecessary drainage, and shortening the operation time will help reduce the incidence of intracranial infection. For patients with contaminated incision and postoperative GCS of less than 8 points, it is necessary to be alert to intracranial infection after craniocerebral operation. [ABSTRACT FROM AUTHOR]

In this study, Maduo county, the source region of the Yellow River, was selected as the research area. In 2017, UAV aerial survey was used to estimate the population of the blue sheep (Pseudois nayaur) and its distribution. The effective area of aerial surveys was 326.6 km2, and 23784 images were acquired. The population in the survey transect was 203, which was identified visually on computer monitors by human observers, and the density was 0.6215/ km2. A total of 12 groups of blue sheep were found in the transects, of which 6 groups had a cluster size of 2-10, accounting for 50% of the total. Estimation of population of blue sheep in Maduo county was 8968, which was based on the relationship of different types of grassland area between transects and the whole county. In this way, the area of non- vegetation types (such as bare stone gravel, water bodies, glaciers, towns, high- speed and national roads) is deducted, and the influence of human disturbance is considered. This avoided overestimation of the blue sheep population. The relationship between the distribution density of blue sheep and ecological factors of habitat was analyzed. Results show that blue sheep preferred an area within 1 km from rural settlements, 3 km away from roads, 1-3 km from water sources, within 200 m from the cliff and with an elevation of 4100-4200 m, vegetation coverage of 0-0.4, slope over 5° , vegetation type of Stipa purpurea + Subordinate grass and Kobresia pygmaea. The environmental factors of the blue sheep habitat may have a correlation with each other, in order to identify the environmental factors that have a major impact on the choice of habitat, and describe the preference more accurately, principal component analysis was carried out. The results showed that altitude, distance from the road and distance from the cliff were the main environmental factors affecting the choice of habitat of blue sheep. In this study, a UAV aerial sampling survey was conducted to estimate the population and density of the blue sheep in the study county. Aided by ArcGIS, the habitat was analyzed. The combination of 3S technology and wildlife surveys provides a new idea for the research on wildlife in the Tibetan Plateau. [ABSTRACT FROM AUTHOR]

Objective To explore the protective effects and mechanism of shikonin on rats with myocardial ischemia/reperfusion(I/R) injury.Methods Forty Sprague-Dawley(SD) rats were randomly divided into the following groups: control group, I/R group, 1 mg/L shikonin group, 5 mg/L shikonin group and 25 mg/L shikonin group, with 8 rats in each group. The in-vitro animal heart perfusion device was used to establish the in-vitro myocardial models of rats. The I/R group was perfused with Krebs-Henseleit(K-H) solution for 30 min, and subjected to 20 min of global ischemia and 45 min of reperfusion. The rats in the 1, 5, and 25 mg/L shikonin groups were perfused with K-H solution for 20 min, then perfused with K-H solution containing shikonin 1, 5, 25 mg/L for 10 min, and then subjected to global ischemia for 20 min and reperfusion for 45 min. The rats in the control group were perfused with K-H solution for 95-min stabilization. The coronary effluent was collected at 10 min before ischemia, at 20 min and 40 min during the reperfusion to detect the content of creatinine kinase(CK) and lactate dehydrogenase(LDH). At the end of reperfusion, parts of the ventricular myocardia were separated and were used to detect myocardial cell apoptosis rate and myocardial necrosis rate, and the other parts of ventricular myocardia were taken to detect the content of malondialdehyde(MDA) and superoxide dismutase(SOD), and the ratio of glutathione/glutathione disulfide(GSH/GSSG), and the protein levels of phosphatidylinositol 3-kinase(PI3 K) and protein kinase B(Akt).Results Compared with the control group, the content of CK and LDH in the coronary effluent, and the content of MDA and SOD in the myocardium, and myocardial apoptosis rate and myocardial necrosis rate significantly increased in the I/R group after I/R, while the ratio of GSH/GSSG significantly decreased(all P<0.05). Compared with the I/R group, the content of CK and LDH in the coronary effluent, and the content of MDA and SOD, and myocardial apoptosis rate and myocardial necrosis rate significantly decreased in the 5 and 25 mg/L shikonin groups, while the ratio of GSH/GSSG significantly increased(all P<0.05); there was no significant difference between the 1 mg/L shikonin group and the I/R group(P>0.05). Compared with the control group, the protein levels of PI3 K and Akt significantly decreased in the myocardia of the I/R group(P<0.05). Compared with the I/R group, the protein expression levels of PI3 K and Akt significantly increased in the myocardia of the 25 mg/L shikonin group(P<0.05).Conclusion Shikonin can alleviate myocardial I/R injury in rats by antioxidation and anti-apoptosis, and its mechanism may be related to activation of PI3 K/Akt signaling pathway. [ABSTRACT FROM AUTHOR]

In order to improve the absolute positioning accuracy of a robot end-effector,a calibration method based on an improved particle swarm algorithm (IPSO) is proposed.Firstly,in order to avoid singularity in the model when two adjacent axes of the robot are parallel or close to parallel,the MDH model of series robot is founded.Secondly,according to the calibration features of robot geometric parameters,IPSO is used to optimize and calibrate the robot geometric parameters.The initial positions are generated based on Halton sequences and the particle velocity is modified by the constriction factor approach.The mathematical model of the objective function to calibrate robot geometric parameters based on IPSO is established,and detailed steps are provided for using IPSO to optimize geometric parameters.The results of the simulation and real calibration of the ER10L-C10 industrial robot show that the proposed method can quickly calibrate the geometric parameters of the robot,and the absolute positioning accuracy of the end-effector is greatly improved.The proposed algorithm is simple and robust,and is suitable to be popularized and applied in industry robot calibration. [ABSTRACT FROM AUTHOR]

Objective To investigate the expressional levels and diagnostic values of miR-18a and miR-21 in esophageal carcinoma. Methods The expressions of miR-18a and miR-21 in esophageal cancer tissues and adjacent tissues from 45 esophageal cancer patients, peripheral blood from 45 esophageal cancer patients and 50 healthy donors respectively were detected by RT-PCR. The expressions of miR-18a and miR-21 in normal esophageal epithelial cell HET-1A, esophageal cancer cell lines including ECA109, KYSE150 and TE1 were also detected. Chemiluminescence immunoassay was used to quantitatively detect the concentrations of carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCC), CYRFA21-1 and TPA (tissue polypeptide antigen) in peripheral blood serum from esophageal cancer patients and healthy controls. Meanwhile, the diagnostic effects of miR-18a and miR-21 on esophageal cancer were compared with those of tumor markers in serum. Results The expression levels of miR-18a and miR-21 in esophageal cancer cells ECA109, KYSE150 and TE1 were 1.64±0.17, 1.62±0.19, 1.46±0.12 and 20.52±1.48, 6.73±0.73, 1.43±0.19, respectively, higher than those in normal esophageal epithelial cells (both P<0.01). The expressions of miR-18a and miR-21 in esophageal cancer tissues were 32.48±28.62 and 8.67±11.98, respectively, significantly higher than those in adjacent tissues (all P<0.001). The expression levels of miR-18a and miR-21 in peripheral blood of patients with esophageal cancer were 12.66±11.92 and 9.15±8.14, respectively, significantly higher than those in the normal control group (both P<0.001). The receiver operating characteristic (ROC) curve analysis showed that the area under the curve of miR-18a and miR-21 for diagnosis of esophageal cancer were 0.948 and 0.913 5, respectively. Compared with traditional esophageal tumor markers, the expressions of miR-18a and miR-21 were more sensitive in the diagnosis of esophageal cancer. The sensitivity and accuracy of the expressions of miR-18a and miR-21 combined with traditional esophageal tumor markers in diagnosis of esophageal cancer can be further improved to 97.8% and 68.4%, respectively. Conclusion Our study reveals that the expressions of miR-18a and miR-21 play important roles in the diagnosis of esophageal cancer and may be potentially novel biomarkers. [ABSTRACT FROM AUTHOR]

To investigate the behavior of reinforced steel anchorage and shear of bonding interface of vertical anchorage connection of prefabricated shear wall, three groups of lap-joint tests and two groups of shear tests based on reinforcement ratio of rebar were conducted to determine the lap length of the vertical bar and to obtain the shear bearing capacity of bonding interface of specimens, the failure mode and the load-displacement curves. The test results show that the selected reinforcement lap length can meet the requirements of bearing capacity. For the same specimen, joint surface 1(interface between post-cast concrete and shear key) is destroyed before joint surface 2(interface between post-cast concrete and grooves). The reinforcement ratio has little influence on the cracking load at the joint surface, but it has a great influence on the shear bearing capacity. When the shear test specimen is damaged, the concrete near the groove is easy to fall off. It was recommended that the tensile reinforcement of shear wall should be made of steel with a diameter greater than 8 mm. The ABAQUS software was used to simulate the shear tests and analyzed the impact of the strength of the post-cast concrete, the width of the post-cast band, the length of the groove and other parameters on the shear capacity of the joint surface. The analysis results show that the shear capacity of joint surface can be improved by increasing the post-cast concrete strength. In the condition of satisfying anchorage requirements, increasing the width of the post-cast band can improve the shear capacity of the wall, while reducing the length of the groove has less influence on the shear capacity of the wall. [ABSTRACT FROM AUTHOR]

Objective To investigate the expression of DNA damage repair genes APE1 and PARP1 in human three negative breast cancer and their correlations with clinicopathological features and prognosis. Methods Sixty patients with three negative infiltrative breast cancer in this hospital from January 2008 to December 2012 were selected. The immunohisto-chemical method was adopted to examine the expression of BRCA1，PARP1 and APE1 in three negative breast cancer tissues. Then their correlation with the tumor prognosis was analyzed. Results The positive expressive rates of APE1，PARP1 and BRCA1 in three negative infiltrative ductal breast cancer were 58.3%（35/60），56.7%（34/60）and 35.0%（21/60）respectively. The PARP1 expression in cancer tissue of axillary lymph node metastasis positive was significantly higher than that in cancer tissue of axillary lymph node metastasis negative，and the difference was statistically significant（P=0.009）；whereas the PARP1 expression had no statistical difference among the onset age，tumor size，tissue differentiation and clinical stages（P> 0.05）；APE1 was positively correlated with PARP1 expression（r=0.489，P<0.001）. The multiple factor Cox regression analysis indicated that the age，axillary lymph node metastasis，poor histological differentiation and APE1 positive expression were the independent prognostic factors of three negative breast cancer. Conclusion The expression of APE and PARP1 is associated with poor prognosis in three-negative breast cancer，and blocking APE1 and PARP1 signaling pathways is expected to become a new therapeutic strategy for three negative infiltrative breast cancer. [ABSTRACT FROM AUTHOR]