复方猴头胶囊联合替普瑞酮对胃溃疡患者胃肠激素、炎性因子及胃窦黏膜TGF-β、Smad3表达的影响.

Objective: To investigate the effect of compound Houtou capsule combined with teprenone on gastrointestinal hormones, inflammatory factors and expression of transforming growth factor-β(TGF-β) and Smad3 in patients with gastric ulcer. Methods: 120 patients with gastric ulcer who were treated in our hospital from January 2017 to January 2020 were selected. According to the method of envelope lottery, they were randomly divided into observation group and control group with 60 cases in each group. Both groups were given esomeprazole orally. On this basis, the control group was treated with tepreidone, and the observation group was given compound Houtou capsule combined with teprenone. The changes of gastrointestinal hormones, inflammatory factors and the expression of TGF-β and Smad3 in gastric antral mucosa of the two groups were observed before and after treatment. The ulcer healing, adverse reaction rate and recurrence rate were compared between the two groups. Results: The total effective rate of ulcer healing of the observation group were significantly higher than those of the control group, the difference was statistically significant (P<0.05). After treatment, the levels of motilin (MTL), gastrin (GAS), C-reactive protein (CRP), interleukin-6 (IL-6) and interleukin-8 (IL-8) of the two groups were all lower than those before treatment, and the levels of the above indicators of the observation group were lower than those of the control group (P<0.05). After treatment, the expression levels of TGF-β and Smad3 of the two groups were decreased compared with those before treatment (P<0.05), and the expressions of TGF-β and Smad3 of the observation group were lower than those of the control group (P<0.05). The recurrence rate of the observation group was significantly lower than that of the control group (P<0.05), but there was no significant difference in the incidence rate of adverse reactions between the two groups (P>0.05). Conclusion: Compound Houtou capsule combined with teprenone can significantly improve the levels of gastrointestinal hormones and inflammatory factors in patients with gastric ulcer, reduce the expression of TGF-β and Smad3 in gastric antral mucosa, promote ulcer healing, and have good safety and low recurrence rate. [ABSTRACT FROM AUTHOR]