PARP1 和 APE1 在三阴乳腺癌中表达的相关性及临床意义.

Objective To investigate the expression of DNA damage repair genes APE1 and PARP1 in human three negative breast cancer and their correlations with clinicopathological features and prognosis. Methods Sixty patients with three negative infiltrative breast cancer in this hospital from January 2008 to December 2012 were selected. The immunohisto-chemical method was adopted to examine the expression of BRCA1，PARP1 and APE1 in three negative breast cancer tissues. Then their correlation with the tumor prognosis was analyzed. Results The positive expressive rates of APE1，PARP1 and BRCA1 in three negative infiltrative ductal breast cancer were 58.3%（35/60），56.7%（34/60）and 35.0%（21/60）respectively. The PARP1 expression in cancer tissue of axillary lymph node metastasis positive was significantly higher than that in cancer tissue of axillary lymph node metastasis negative，and the difference was statistically significant（P=0.009）；whereas the PARP1 expression had no statistical difference among the onset age，tumor size，tissue differentiation and clinical stages（P> 0.05）；APE1 was positively correlated with PARP1 expression（r=0.489，P<0.001）. The multiple factor Cox regression analysis indicated that the age，axillary lymph node metastasis，poor histological differentiation and APE1 positive expression were the independent prognostic factors of three negative breast cancer. Conclusion The expression of APE and PARP1 is associated with poor prognosis in three-negative breast cancer，and blocking APE1 and PARP1 signaling pathways is expected to become a new therapeutic strategy for three negative infiltrative breast cancer. [ABSTRACT FROM AUTHOR]