51. Novel Functions of MicroRNA-17-92 Cluster in the Endocrine System
- Author
-
Xiang Chen, Shan Wan, Yuedong He, and Xijie Yu
- Subjects
0301 basic medicine ,Clinical Biochemistry ,Endocrine System ,Biology ,Bioinformatics ,Disease cluster ,Bone and Bones ,Bone remodeling ,03 medical and health sciences ,Insulin resistance ,Osteogenesis ,Drug Discovery ,microRNA ,medicine ,Animals ,Homeostasis ,Humans ,Glucose homeostasis ,Pharmacology ,Lipogenesis ,Lipid metabolism ,Lipid Metabolism ,medicine.disease ,MicroRNAs ,Glucose ,030104 developmental biology ,Gene Expression Regulation ,Molecular Medicine ,RNA, Long Noncoding ,Insulin Resistance ,Signal transduction ,Function (biology) ,Signal Transduction - Abstract
Background MiR-17-92 cluster is coded by MIR17HG in chromosome 13, which is highly conserved in vertebrates. Published literatures have proved that miR-17-92 cluster critically regulates tumorigenesis and metastasis. Recent researches showed that the miR-17-92 cluster also plays novel functions in the endocrine system. Objective To summarize recent findings on the physiological and pathological roles of miR-17-92 cluster in bone, lipid and glucose metabolisms. Results MiR-17-92 cluster plays significant regulatory roles in bone development and metabolism through regulating the differentiation and function of osteoblasts and osteoclasts. In addition, miR-17- 92 cluster is nearly involved in every aspect of lipid metabolism. Last but not the least, the miR-17-92 cluster is closely bound up with pancreatic beta cell function, development of type 1 diabetes and insulin resistance. However, whether miR-17-92 cluster is involved in the communication among bone, fat and glucose metabolisms remains unknown. Conclusion Growing evidence indicates that miR-17-92 cluster plays significant roles in bone, lipid and glucose metabolisms through a variety of signaling pathways. Fully understanding its modulating mechanisms may necessarily facilitate to comprehend the clinical and molecule features of some metabolic disorders such as osteoporosis, arthrosclerosis and diabetes mellitus. It may provide new drug targets to prevent and cure these disorders.
- Published
- 2018