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MicroRNAs in Lung Cancer and Lung Cancer Bone Metastases: Biomarkers for Early Diagnosis and Targets for Treatment
- Source :
- Recent Patents on Anti-Cancer Drug Discovery. 10:182-200
- Publication Year :
- 2015
- Publisher :
- Bentham Science Publishers Ltd., 2015.
-
Abstract
- Lung cancer is the leading cause of malignancy-related mortality worldwide. Metastases, which account for 90% of lung cancer deaths, frequently target the skeleton, leading to rapid deterioration in quality of life and premature death. The molecular mechanism underlying this progression, especially the development of bone metastases, is largely unknown. MicroRNAs (miRNAs) are small, endogenous, noncoding RNAs that function as negatively posttranscriptional gene regulators. Changes in miRNAs, which may exhibit either oncogenic or tumor suppressive activity, are common in lung cancer. Over-expressed miRNAs may contribute to oncogenesis by down-regulating tumor suppressors, whereas the loss of selected miRNAs may negatively regulate oncogenes or factors related to tumorigenesis and progression. MiRNAs may activate or repress metastases. Specific miRNA expression profiles may correlate with the response in treatment. We summarize recent findings and patents in the pathological roles of miRNAs in the progression and bone metastases in lung cancer, and discuss the diagnostic and therapeutic options in the clinical management of lung cancer.
- Subjects :
- Cancer Research
Lung Neoplasms
Bone Neoplasms
Endogeny
Biology
medicine.disease_cause
law.invention
Patents as Topic
law
Drug Discovery
microRNA
Biomarkers, Tumor
medicine
Animals
Humans
Pharmacology (medical)
Lung cancer
Gene
Pathological
Early Detection of Cancer
General Medicine
medicine.disease
MicroRNAs
Oncology
Immunology
Disease Progression
Quality of Life
Cancer research
Suppressor
Carcinogenesis
Function (biology)
Subjects
Details
- ISSN :
- 15748928
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Recent Patents on Anti-Cancer Drug Discovery
- Accession number :
- edsair.doi.dedup.....8d105e545733d7498bee89efe57ba6e6