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Interferon-Gamma-Mediated Osteoimmunology
- Source :
- Frontiers in Immunology, Vol 9 (2018), Frontiers in Immunology
- Publication Year :
- 2018
- Publisher :
- Frontiers Media S.A., 2018.
-
Abstract
- Osteoimmunology is the interdiscipline that focuses on the relationship between the skeletal and immune systems. They are interconnected by shared signal pathways and cytokines. Interferon-gamma (IFN-γ) plays important roles in immune responses and bone metabolism. IFN-γ enhances macrophage activation and antigen presentation. It regulates antiviral and antibacterial immunity as well as signal transduction. IFN-γ can promote osteoblast differentiation and inhibit bone marrow adipocyte formation. IFN-γ plays dual role in osteoclasts depending on its stage. Furthermore, IFN-γ is an important pathogenetic factor in some immune-mediated bone diseases including rheumatoid arthritis, postmenopausal osteoporosis, and acquired immunodeficiency syndrome. This review will discuss the contradictory findings of IFN-γ in osteoimmunology and its clinical application potential.
- Subjects :
- 0301 basic medicine
rheumatoid arthritis
lcsh:Immunologic diseases. Allergy
Osteoimmunology
Immunology
Review
Bone remodeling
postmenopausal osteoporosis
03 medical and health sciences
0302 clinical medicine
Immune system
Macrophage
Medicine
Immunology and Allergy
Interferon gamma
osteoimmunology
human immunodeficiency virus
business.industry
osteoblasts
Osteoblast
030104 developmental biology
medicine.anatomical_structure
osteoclasts
Bone marrow
interferon-gamma
Signal transduction
business
lcsh:RC581-607
030215 immunology
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 16643224
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Frontiers in Immunology
- Accession number :
- edsair.doi.dedup.....0db10ccdcc9e99733729d049d0cd7a25