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Immune Cells Act as Promising Targets for the Treatment of Bone Metastasis
- Source :
- Recent patents on anti-cancer drug discovery. 12(3)
- Publication Year :
- 2016
-
Abstract
- Background: Bone metastasis is a common complication of certain types of cancer, and unfortunately, it is still incurable to date. Immune system is a major defence against tumor cells and bone metastasis. However, the immunodeficient mouse models are widely used in most researches of bone metastasis, thereby excluding the regulatory roles of the immune system in bone metastasis. Objective: To provide a comprehensive overview on the cellular and molecular mechanisms by which immune cells interact with tumor cells and bone cells, as well as recent related patents. Method: We performed a literature search of PubMed database for the current knowledge in the interaction between bone metastasis and immune system. Recent related patents were obtained from World Intellectual Property Organization (WIPO) website. Results: Immune cells in the bone-tumor microenvironment include dentritic cells, monocytes/macrophages, myeloid-derived suppressor cells, regulatory T cells, T helper cells, neutrophil, CD4+ T lyphocytes, CD8+cytotoxic T lymphocytes, and natural killer cells, et al. In addition to their well-known immunomodulatory function, recent studies revealed that immune cells could cooperate with tumor cells and bone cells to enhance bone metastasis and tumor progression. There are some patents targeted immune system to inhibit bone metastasis. Conclusion: Immune cells are instigated by tumor cells to enhance the occurrence and the development of bone metastasis. Taking full advantage of anti-tumor roles of immune cells may bring the promise of a possible cure for bone metastasis.
- Subjects :
- 0301 basic medicine
Cancer Research
Bone Neoplasms
Biology
Patents as Topic
03 medical and health sciences
Mice
Immune system
Neoplasms
Drug Discovery
Bone cell
medicine
Tumor Microenvironment
Cytotoxic T cell
Animals
Humans
Pharmacology (medical)
Multiple myeloma
Immunodeficient Mouse
Bone metastasis
General Medicine
medicine.disease
030104 developmental biology
Oncology
Tumor progression
Immune System
Immunology
Disease Progression
CD8
Subjects
Details
- ISSN :
- 22123970
- Volume :
- 12
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Recent patents on anti-cancer drug discovery
- Accession number :
- edsair.doi.dedup.....99df3d5fbe17240a1c5654bdffc51e4e