1. Cytotoxic Activity of New Tropinene Glycoside Isolated from Solandra grandiflora Sw.
- Author
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Mohammed, Magdy M. D., Spiteller, Michael, Ibrahim, Nabaweya A., and Mohamed, Khaled M.
- Subjects
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PLANT extracts , *GLYCOSIDES , *CHLOROGENIC acid , *BOTANICAL chemistry , *SPECTRUM analysis - Abstract
The first phytochemical investigation of Solandra grandiflora Sw. leaves using LC/MS resulted in the identification without isolation of eight known and one unknown compounds from the neutral and the alkaloidal fractions. Further chromatographic fractionation and isolation of both fractions using RP-HPLC resulted in the isolation of chlorogenic acid, neochlorogenic acid, protocatechuic acid, scopoletin and isoscopoletin from the neutral fraction. Moreover, a new tropinene glycoside identified as 3-O-β-D-glucosyl 6-tropinene, together with atropine, scopolamine and hyoscyamine were isolated from the alkaloidal fraction. The structures of all isolated compounds were established and confirmed by 1H-, 13C-NMR, COSY, HSQC & HMBC spectroscopy, while the exact masses were confirmed by HRESIMS. The cytotoxic activity of all isolates was evaluated against HepG-2, HCT-116, A-549 and MCF-7, and the obtained results suggested selective antiproliferative and cytotoxic effect. [ABSTRACT FROM AUTHOR]
- Published
- 2016