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Anti-inflammatory tirucallane triterpenoids from Anopyxis klaineana Pierre (Engl.), (Rhizophoraceae).
- Source :
-
Fitoterapia . Oct2015, Vol. 106, p84-91. 8p. - Publication Year :
- 2015
-
Abstract
- Phytochemical investigation of the stem bark extract of Anopyxis klaineana was carried out by various chromatographic techniques resulting in the isolation and characterization of three new tirucallane triterpenoids, namely 3,23-dioxotirucalla-7,24-dien-21-oic acid ( 1 ), 3,4-secotirucalla-23-oxo-4(28)7,24-trien-3,21-dioic acid ( 2 ) and 3,4-secotirucalla-4-hydroxy-23-oxo-7,24-diene-3,21-dioic acid-21-methyl ester ( 3 ), along with nine known compounds ( 4–12 ). The structural elucidation of the compounds was performed by means of high-resolution mass spectrometry (HRMS n ), nuclear magnetic resonance (NMR), and by comparison to literature data. Although none of the isolated compounds showed antibacterial efficacy against selected environmental and clinically important pathogenic Gram-positive and -negative bacteria, they demonstrated moderate DPPH free radical scavenging properties. Furthermore, compounds 1 and 7 exhibited remarkable anti-inflammatory potential in a prostaglandin E 2 (PGE 2 ) competitive enzyme immunoassay with IC 50 values of 3.63 μM and 10.23 μM, respectively. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ALTERNATIVE medicine
*ANTI-inflammatory agents
*BARK
*PHYSICAL & theoretical chemistry
*CHROMATOGRAPHIC analysis
*DOSE-effect relationship in pharmacology
*FREE radicals
*IMMUNOASSAY
*MASS spectrometry
*MEDICINAL plants
*NUCLEAR magnetic resonance spectroscopy
*PROSTAGLANDINS
*PLANT stems
*PLANT extracts
*DESCRIPTIVE statistics
*IN vitro studies
Subjects
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 106
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 110149353
- Full Text :
- https://doi.org/10.1016/j.fitote.2015.08.007