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Isoflavones from the seedpods of Tephrosia vogelii and pyrazoisopongaflavone with anti-inflammatory effects.
- Source :
-
Fitoterapia . Oct2020, Vol. 146, pN.PAG-N.PAG. 1p. - Publication Year :
- 2020
-
Abstract
- Phytochemical investigation of Tephrosia vogelii seedpods led to the isolation of twelve compounds: vogelisoflavone A (1), vogelisoflavone B (2), isopongaflavone (3), onogenin, luteolin, 4′,7-dihydroxy-3′-methoxyflavanone, trans - p -hydroxycinnamic acid, tephrosin, 2-methoxygliricidol, dehydrorotenone, 6a,12a-dehydro-α-toxicarol and pinoresinol. Compounds 1 and 2 are reported as new natural products. Isopongaflavone (3) was structurally modified using hydrazine to pyrazoisopongaflavone (4). These compounds were characterized based on their NMR and HRESIMS data. Further, four compounds (1–4) were evaluated for their anti-inflammatory effects in lipopolysaccharide (LPS)-stimulated peripheral blood mononuclear cells (PBMCs). Treatment of the LPS-stimulated PBMCs with the compounds at a concentration of 100 μM suppressed the secretion of interleukin IL-1β interferon-gamma (IFN-γ), granulocyte macrophage-colony stimulating factor (GM-CSF) and tumour necrosis factor-alpha (TNF-α). Unlabelled Image • Twelve compounds were isolated from Tephrosia vogelii seedpods. • Two new isoflavones vogelisoflavone A (1) and vogelisoflavone B (2) are reported as new compounds. • Isopongaflavone was modified using hydrazine to pyrazoisopongaflavone. • The compounds exhibited anti-inflammatory effects. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANTI-inflammatory agents
*GRANULOCYTE-macrophage colony-stimulating factor
*INTERFERONS
*INTERLEUKIN-1
*LIQUID chromatography
*MOLECULAR structure
*NUCLEAR magnetic resonance spectroscopy
*TUMOR necrosis factors
*PLANT extracts
*ISOFLAVONES
*ELECTROSPRAY ionization mass spectrometry
*MONONUCLEAR leukocytes
*IN vitro studies
*PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 146
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 146428330
- Full Text :
- https://doi.org/10.1016/j.fitote.2020.104695