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Minor secondary metabolites from the bark of Entandrophragma congoënse (Meliaceae).
- Source :
-
Fitoterapia . Apr2015, Vol. 102, p35-40. 6p. - Publication Year :
- 2015
-
Abstract
- Two new tirucallane-type triterpenoids were isolated from the bark of Entandrophragma congoënse (Meliaceae) along with five known compounds gladoral A, bipendensin, 4-hydroxymethyl-3,5-dimethyldihydrofuran-2(3 H )-one, scopoletin and 5,7-dimethoxy-6-hydroxycoumarin. Their structures were elucidated by means of spectroscopic analyses including 1D and 2D-NMR spectroscopy, high resolution mass spectrometric data as well as the comparison of data with those reported in the literature. The tested compounds ( 1 – 4 ) displayed moderated antiplasmodial activity against erythrocytic stages of chloroquine-resistant Plasmodium falciparum strain NF54 and low cytotoxicity on L6 cell lines. All the isolated compounds are reported for the first time from the genus Entandrophragma. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ALTERNATIVE medicine
*ANIMAL experimentation
*ANTIMALARIALS
*BARK
*BIOLOGICAL models
*PHYSICAL & theoretical chemistry
*DRUG resistance
*DRUG toxicity
*MASS spectrometry
*MEDICINAL plants
*MICROBIAL sensitivity tests
*NUCLEAR magnetic resonance spectroscopy
*RATS
*SPECTRUM analysis
*PLANT extracts
*DESCRIPTIVE statistics
*IN vitro studies
*PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 102
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 101927702
- Full Text :
- https://doi.org/10.1016/j.fitote.2015.01.018