Back to Search
Start Over
Cardenolides and dihydro-β-agarofuran sesquiterpenes from the seeds of Salacia staudtiana.
- Source :
-
Fitoterapia . Nov2018, Vol. 131, p174-181. 8p. - Publication Year :
- 2018
-
Abstract
- Abstract Phytochemical studies of the seeds of the Cameroonian medicinal plant, Salacia staudtiana , resulted in the isolation and identification of five new cardenolides (1 – 5) as well as a new dihydro-β-agarofuran (9), along with eight known compounds. The structures of all compounds were elucidated by 1D/2D NMR, ESI-HRMS data and comparison with literature data. The relative configurations of the new compounds were defined by X-ray crystallography analysis, NOESY correlations and coupling constants. We evaluated their antibacterial efficacy against two commonly dispersed environmental strains of Escherichia coli and Bacillus subtilis , and two pathogenic strains of Staphylococcus aureus and Pseudomonas aeruginosa , compared to the standard antibiotics, streptomycin and gentamicin. Moreover, we assessed the antibacterial activity of the crude extract of the seeds in parallel to evaluate the plausible synergistic effects of the compounds in chemical defense of the seeds during germination and plant reproduction. The isolated compounds showed moderate antibacterial activities against the tested organisms. Compounds 1 and 3 and the crude extract exhibited distinct antibacterial activities against B. subtilis and S. aureus. The isolated compounds showed weak DPPH radical scavenging properties compared to the reference standard (Trolox). Our study lends evidence to the antibacterial chemical defense of S. staudtiana seeds by seed-borne compounds. Graphical abstract Unlabelled Image [ABSTRACT FROM AUTHOR]
- Subjects :
- *HYDROCARBON analysis
*STEROIDS analysis
*BACILLUS (Bacteria)
*BIOLOGICAL assay
*CRYSTALLIZATION
*CRYSTALLOGRAPHY
*ESCHERICHIA coli
*GENTAMICIN
*HIGH performance liquid chromatography
*HYDROCARBONS
*MASS spectrometry
*MEDICINAL plants
*MOLECULAR structure
*NUCLEAR magnetic resonance spectroscopy
*PSEUDOMONAS
*SEEDS
*STAPHYLOCOCCUS aureus
*STEROIDS
*STREPTOMYCIN
*THIN layer chromatography
*X-rays
*PLANT extracts
*AUTOANALYZERS
Subjects
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 131
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 133168611
- Full Text :
- https://doi.org/10.1016/j.fitote.2018.10.025