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Researchers at Aix-Marseille University in Marseille, France have identified a new class of small-molecule inhibitors that show promise in treating enterovirus infections. Enteroviruses are a genus of RNA viruses that can cause various diseases, particularly in children and immunocompromised individuals. Currently, there are no approved treatments for enteroviruses, except for polioviruses and EV-A71 in China. The new inhibitors target the viral capsid and have shown activity against EV-A71, with potential for broad-spectrum treatment. Further research is needed to develop these inhibitors into effective antiviral drugs. [Extracted from the article]

Researchers from Aix-Marseille University in Marseille, France have conducted a study on protease-activatable alkoxyamine prodrugs to fight cancer. These prodrugs consist of a peptide linked to an alkoxyamine, and when the peptide is proteolyzed, it converts the stable prodrug into a metastable alkoxyamine that induces cell death. The researchers found that by varying the peptide moiety, they were able to switch the activating enzyme from elastase to urokinase, and these prodrugs successfully destroyed cancer cell lines and cells from tumor explants. The study was supported by the European Union. [Extracted from the article]

A report from Aix-Marseille University discusses the prevalence and intensity of urogenital schistosomiasis in schoolchildren in the lake zones of Kankossa and Oued Rawdha in southern Mauritania. The study found that the prevalence of urogenital schistosomiasis was moderate in both villages, with higher rates in boys and Koranic school pupils. The research also identified the species of intermediate host snails and detected schistosome DNA in some snails. The study suggests that mass drug administration campaigns should be conducted to reduce the prevalence of urogenital schistosomiasis in these areas, and further research is needed to strengthen knowledge and implement control strategies. [Extracted from the article]

A recent study conducted at University Hospital Nord in Marseille, France, examined the diagnostic value of serum angiotensin-converting enzyme (ACE) levels in pediatric sarcoid uveitis. Sarcoid uveitis is a rare condition in children, and early diagnosis is crucial due to potential complications. The study found that the diagnostic performance of ACE in pediatric sarcoid uveitis was poor, with a low sensitivity and positive predictive value. The researchers concluded that serum ACE should be interpreted alongside other factors and used with caution as a diagnostic marker for pediatric sarcoid uveitis. [Extracted from the article]

Researchers at Aix-Marseille University in Marseille, France have developed a rapid polymorphic screening approach for Mannitol Therapy. The approach involves contracting sessile microdroplets, which allows for high supersaturation and systematic labeling of samples. The researchers studied the competitive nucleation of d-mannitol polymorphs and investigated the effect of droplet volume on polymorphic selectivity. This microfluidic approach has potential applications in routine screening of pharmaceutical solid forms and in understanding the competitive nature of polymorphic nucleation. The research has been peer-reviewed and published in CrystEngComm. [Extracted from the article]

A recent study conducted by researchers from Veracyte Inc. in Marseille, France, aimed to validate the prognostic value of Immunoscore (IS) in stage II colorectal cancer (CRC) and explore the roles of IS and circulating tumor DNA (ctDNA) in the adjuvant treatment for early-stage CRC. The study found that patients with high IS had an excellent clinical outcome, with none recurring during a median follow-up of 3 years. Additionally, IS had a strong prognostic value in Chinese patients with stage II CRC. The researchers concluded that IS and ctDNA can optimize adjuvant treatment strategies for early-stage CRC. [Extracted from the article]

Researchers from Aix-Marseille University in Marseille, France, have reported on a case of optic neuritis in an 82-year-old man. The patient experienced bilateral visual blurring and was diagnosed with papilledema. Further tests revealed the presence of anti-immunoglobulin-like cell adhesion molecule 5 (anti-IgLON5) autoantibodies. Treatment with cyclophosphamide and rituximab was initiated, and the patient's ophthalmologic symptoms improved during the 6-month follow-up period. This research has been peer-reviewed and published in Neurology. [Extracted from the article]

Researchers at North University Hospital in Marseille, France have presented new data on esophageal fistula, a condition characterized by abnormal connections between the esophagus and other organs. The researchers discussed the case of a patient with esophageal cancer who developed an esophageal stenosis and a broncho-esophageal fistula as a complication of chemotherapy and radiotherapy. The patient was treated with multiple palliative stenting procedures and colonic surgical bypass. In an unusual form of treatment called physiological lung exclusion, the patient experienced clinical benefit without any drawbacks related to the procedure. The research has been peer-reviewed and published in Respiratory Medicine and Research. [Extracted from the article]

A report from Aix-Marseille University discusses the challenges faced by viticulture practices in Southeastern France due to climate change and poor soil quality. The researchers conducted a field survey to assess the effects of green waste amendment (GWA) and grass cover (GC) on vineyard soil functionality. The study found that both practices improved soil physicochemical properties and favored soil microbial communities. The researchers concluded that GWA has the potential to counteract the effects of tillage, mitigate drought stress, and improve overall soil functionality in vineyards. [Extracted from the article]

A recent study conducted by researchers at Aix-Marseille University in Marseille, France, has provided new information about the activation cascade of the broad-spectrum antiviral drug Bemnifosbuvir. The study found that Bemnifosbuvir requires a minimal set of five cellular enzymes for activation to its common 5'-triphosphate form. The researchers also discovered the specific enzymes involved in the activation pathway and characterized each enzymatic complex at atomic resolution. This research provides valuable insights into the design of antiviral nucleotide analogues and their activation mechanisms. [Extracted from the article]

A recent study conducted by researchers at Aix-Marseille University in Marseille, France, has found that a low frequency of Vg9vs2 G 9v S 2 T cells predicts poor survival in newly diagnosed acute myeloid leukemia (AML) patients. The study analyzed peripheral blood samples from 198 patients with newly diagnosed AML and found that patients with lower levels of Vg9vs2 T cells had significantly lower 5-year overall and relapse-free survival rates. The study suggests that enhancing Vg9vs2 T-cell responses could be a potential strategy for improving outcomes in AML patients. This research has been peer-reviewed and published in Blood Advances. [Extracted from the article]

A recent report from Marseille, France discusses the impact of nighttime personalized non-pharmacological therapies (PNPT) on caregivers in nursing homes who are dealing with residents with dementia. The study found that caregivers in nursing homes that used PNPT reported higher levels of perceived health, better quality of care, lower stress symptoms and workload, and increased satisfaction with work compared to those in nursing homes that did not use PNPT. The research suggests that PNPT may have benefits for caregivers in managing the behavioral and psychological symptoms of dementia. This information may be useful for individuals researching dementia care and support in nursing homes. [Extracted from the article]

A study conducted by researchers at Aix-Marseille University in Marseille, France, focused on the fate of the right coronary artery in a neonate with a surgically repaired aorto-ventricular tunnel. The aorto-ventricular tunnel is a rare congenital cardiac anomaly, and the researchers presented a case of its diagnosis via fetal echocardiography. Emergency surgery was performed to close the tunnel, which resulted in complete occlusion of the right coronary artery. The patient, however, recovered fully without the need for further coronary intervention. The study emphasizes the importance of caution when intervening in the coronary arteries of patients with an aorto-ventricular tunnel and associated coronary lesions. [Extracted from the article]

New research on Psychology and Psychiatry from the National Center for Scientific Research (CNRS) in Marseille, France, explores the theoretical stance proposed by the author in response to comments made on their opinion article. The research argues that the Hebbian project, which aims to find a middle ground between mentalist psychology and radical reductionism, provides conceptual keys to understanding chunking mechanisms and has the potential to unify disjointed fields of psychology. The research has been peer-reviewed and can be accessed through the journal L'Annee psychologique. For more information, contact Arnaud Rey at CNRS in Marseille, France. [Extracted from the article]

A recent report from Marseille, France discusses the use of postmortem CT and MRI scans in diagnosing pediatric bowel obstruction (BO) as the cause of septic shock-induced death. The study analyzed six cases of pediatric septic shock and found that postmortem CT scans revealed signs of BO in all cases, while MRI scans did not provide additional diagnostic information. The researchers suggest that combining these imaging modalities could enhance diagnostic accuracy and provide a more complete understanding of the cause of death in children. Further exploration of the role of MRI in conjunction with CT and autopsy is warranted. [Extracted from the article]

A recent study conducted in Marseille, France, explored the use of intranasal esketamine as a treatment option for patients with treatment-resistant depression (TRD). The study focused on a 31-year-old patient with severe and chronic TRD who had previously tried multiple antidepressants and neurostimulation techniques without success. The patient received an acute course of intranasal esketamine and underwent over 20 bi-weekly sessions, experiencing no significant adverse effects and achieving remission. This case report highlights the potential of intranasal esketamine as a treatment option for severe TRD. [Extracted from the article]

A recent report from the Department of Medical Oncology in Marseille, France discusses the use of trifluridine/tipiracil (FTD/TPI) in the treatment of advanced/metastatic gastric and gastroesophageal junction adenocarcinomas (aGA/GEJA). The combination of FTD/TPI with oxaliplatin and nivolumab has shown promising results and a manageable safety profile. The study aims to evaluate the efficacy and safety of FTD/TPI plus oxaliplatin with or without nivolumab compared to the standard of care FOLFOX regimen in patients with HER2 negative aGA/GEJA who are not eligible for triplet chemotherapy. The study is a prospective randomized trial that will include 118 patients. Nivolumab will be used for patients whose tumors express PD-L1 with a CPS score >= 5. This research provides valuable data on the association of FTD/TPI plus oxaliplatin with or without nivolumab in the first-line palliative setting for patients with aGA/GEJA. [Extracted from the article]

A recent study conducted at the Public Assistance Hospital of Marseille (AP-HM) in France aimed to determine weight-specific reference liver stiffness values in children without liver disease. The study used 2-D shear wave elastography to measure liver stiffness in 171 pediatric patients. The results showed that liver stiffness increased with weight, and the mean normal liver stiffness value for all children was 5.3 (+-) 1.1 kPa. These findings may be useful in distinguishing between normal and pathological elastography values. The study was published in the journal Pediatric Radiology. [Extracted from the article]

Researchers at Aix-Marseille University in Marseille, France have conducted a review of antibody-drug conjugates (ADCs) as a treatment option for breast cancer. ADCs are a new class of therapies that combine a cytotoxic agent with a monoclonal antibody. While ADCs have shown promise in widening the therapeutic index and mitigating toxicities, managing treatment-related adverse events remains a challenge. The researchers aim to provide an overview of the toxicity profiles of ADCs currently in clinical practice or under development. This research has been peer-reviewed and published in the Bulletin du Cancer. [Extracted from the article]

A recent study conducted at Timone University Hospital in Marseille, France, has provided new insights into calcified chondroid mesenchymal neoplasms (CCMNs), a type of soft tissue tumor. The researchers collected 33 cases of CCMN and performed various analyses, including whole-exome RNA sequencing and genome-wide DNA methylation profiling. They found that 76% of the cases had fusion of the FN1 gene, with different partner genes. Additionally, a subgroup of tumors located at the temporomandibular joint (TMJ) exhibited features similar to tenosynovial giant cell tumors (TGCT) and had FN1::TEK fusions. This study confirms the prevalence of FN1 fusions in CCMNs and identifies a novel subgroup of TMJ tumors. [Extracted from the article]

A recent report discusses research conducted at Aix-Marseille University on regenerative medicine and the use of photopolymerization. The study focuses on the migration of photoinitiators within polymer networks, which has raised safety concerns in various applications such as food production, dentistry, biomaterials, and regenerative medicine. Thioxanthone, a popular photoinitiator, has been found to easily migrate within the polymer network. Researchers have therefore developed strategies to immobilize thioxanthone through copolymerization or radical addition on monomers. The research has been peer-reviewed and further information can be obtained from Aix-Marseille University. [Extracted from the article]

A study conducted at University Hospital Timone in Marseille, France, explored the relationship between clot composition and fibrinolysis in the acute phase of stroke. The researchers used an observational proteomic study to analyze the thrombi retrieved from stroke patients who underwent mechanical thrombectomy. They found that factors such as recombinant tissue-type plasminogen activator (r-tPA) administration and thrombus composition influenced fibrinolytic activity. The study suggests that proteomics can provide valuable insights into the connection between thrombus composition and susceptibility to fibrinolysis, potentially leading to new adjuvant therapies. [Extracted from the article]

A recent study conducted by researchers from Aix-Marseille University in Marseille, France, aimed to assess the practices and knowledge of general practitioners (GPs) regarding erectile dysfunction (ED). The study found that ED is often overlooked by GPs, despite its potential association with underlying coronary artery disease. The survey revealed that many GPs did not follow recommended treatment guidelines and lacked knowledge about various treatment options. The researchers suggest that improving training and providing practical guidelines could help GPs better detect and manage ED, which could serve as an indicator of coronary heart disease. [Extracted from the article]

A report from the Public Assistance Hospital of Marseille (AP-HM) in France discusses research findings on hyperkalemia, a condition characterized by high levels of potassium in the blood. Hyperkalemia is common in patients with chronic renal failure, diabetes, or those receiving treatment with inhibitors of the renin-angiotensin-aldosterone system (iRAAS). The report highlights the importance of managing hyperkalemia to prevent complications and avoid discontinuation of cardio- and nephroprotective treatments. It also mentions two new potassium exchange molecules, patiromer and zirconium sulfonate, which have recently become available on the market. The choice of treatment should be tailored to the patient's specific conditions and consider the other effects of these medications. [Extracted from the article]

A report from Aix-Marseille University in France discusses the evaluation of a medically coordinated care program for children with autism spectrum disorders (ASD). The study compares the effectiveness of this program with the care provided in day care hospitals (DCH) for child psychiatry. The results show that both groups of children, those in the coordinated care program and those in DCH, showed improvements in autism severity and socio-adaptive behavior. However, the reduction in autism severity was more significant in the coordinated care program. The researchers suggest that further research with larger numbers of participants could demonstrate the non-inferiority of coordinated care programs in comparison to DCH. [Extracted from the article]

A study conducted at Aix-Marseille University in Marseille, France, examined the long-term outcomes of active surveillance (AS) in patients with favorable intermediate-risk prostate cancer. The study found that AS is a safe and effective strategy for selected patients, with no cases of metastasis or death due to prostate cancer during the follow-up period. The research also identified factors associated with the risk of undergoing definitive treatment, such as PSA density and lesions on mpMRI. These findings suggest that AS can be a valuable approach for managing favorable intermediate-risk prostate cancer. [Extracted from the article]

A recent report from Aix-Marseille University in Marseille, France discusses the challenges in diagnosing pulmonary actinomycosis, a rare infectious disease. The disease can be difficult to diagnose due to nonspecific imaging abnormalities, requiring repeated lung sampling for accurate diagnosis. The report highlights a case of pulmonary actinomycosis and describes the use of thoracic CT, digital subtraction angiography, and pathological specimens for imaging. The research emphasizes the potential need for bronchial artery embolization in cases of hemoptysis. This information may be useful for researchers and medical professionals studying Actinomycetales Infections and Actinomycosis. [Extracted from the article]

Researchers at Aix-Marseille University in Marseille, France have conducted a study on the synthesis and characterization of phenazinium dyes with absorption ranging from red to far-red, as well as emission extending into the far-red to near-infrared (NIR) region. The study demonstrates the possibility of redshifting the absorption and emission properties of these dyes through a one-step post-synthesis strategy involving the introduction of an electron-withdrawing group. The isolated dyes show promise for future applications as biological markers or therapeutic agents. The research was funded by Agence Nationale de la Recherche and Centre National de la Recherche Scientifique. [Extracted from the article]

A study conducted in Marseille, France, examined the recurrence of anterior congenital diaphragmatic hernia (CDH) after laparoscopic repair in children, with a specific focus on those with Down syndrome. The study found that laparoscopic repair without a patch was a safe and effective surgical approach for children with anterior CDH. However, the recurrence rate was higher in patients with Down syndrome and when absorbable sutures were used. The researchers recommend considering the use of a non-absorbable prosthetic patch in cases involving Down syndrome or previous cardiac surgery. [Extracted from the article]

Researchers at Conception Hospital in Marseille, France have updated the clinical practice guidelines for the first-line management of infertile couples. The guidelines cover five major themes, including the assessment of the infertile woman and man, prevention of exposure to environmental factors, ovulation induction regimens, and reproductive surgery. The recommendations were formulated based on a systematic review of the literature and validated by national experts. The guidelines provide recommendations for various aspects of infertility work-up and management, including diagnostic tests, lifestyle factors, and surgical interventions. [Extracted from the article]

A recent study conducted at La Timone Hospital in Marseille, France, examined the occurrence and impact of high-degree atrioventricular block in patients with aortic valve infective endocarditis. The study included 205 patients and found that high-degree atrioventricular block occurred in 11% of cases. The researchers identified several factors associated with high-degree atrioventricular block, including first-degree heart block at admission, periannular complications on echocardiography, and high levels of inflammation markers. The study also found that in-hospital mortality was higher in patients with high-degree atrioventricular block. The researchers suggest that a systematic assessment of patients with infective endocarditis could help identify those at highest risk and guide appropriate monitoring and treatment. [Extracted from the article]

A study conducted at the University Hospital in Marseille, France, provides new insights into tetrahydrocannabinol (THC), a component of the Cannabis sativa plant. The research focuses on cannabidiol (CBD), another important component of the plant, which is used for both medical and recreational purposes. The study highlights the need for better understanding of CBD's pharmacological properties and its potential drug interactions, as it is increasingly being used. The research concludes that there are several drug-drug interactions with CBD, and aims to assist clinicians in their practice. [Extracted from the article]

Researchers at University Hospital Center La Timone in Marseille, France have published a report on the indications for atrial fibrillation (AF) ablation. The study highlights how AF ablation has become a widely used treatment for patients with healthy hearts, as well as those with severe heart disease and heart failure, and even those awaiting transplantation. The report also discusses the role of AF ablation as a first-line treatment before trying antiarrhythmic therapy, and the prognostic value of AF ablation in heart failure patients. This research has been peer-reviewed and can be accessed through the Bulletin de l'Academie Nationale de Medecine. [Extracted from the article]

A study conducted at La Timone Hospital in Marseille, France, aimed to assess the association between left ventricular trabeculation and cardiovascular risk factors. The researchers used automated segmentation to analyze cardiac MRI scans from the UK Biobank and compared individuals with and without cardiovascular risk factors. They found that higher body mass index, hypertension, and higher physical activity level were associated with higher trabeculated left ventricular mass. The study also established age- and sex-specific reference ranges for trabeculated left ventricular mass in a healthy middle-aged White population. [Extracted from the article]

A recent study conducted at Timone Hospital in Marseille, France, explored the potential psychiatric complications of SEEG-guided radiofrequency thermocoagulation (RF-TC) in patients with drug-resistant epilepsy. The study found that out of 164 patients, 4.2% experienced psychiatric decompensation after RF-TC of the amygdala and hippocampus. These symptoms varied in duration and severity, and were more common in female patients with mesial temporal epilepsy and a history of psychological distress and memory dysfunction. The study concludes that while neuropsychiatric deterioration following SEEG-guided RF-TC is rare, it is still a possibility. [Extracted from the article]

A recent study from Aix-Marseille University explores an alternative approach to studying animal behavior called etho-phenomenology. The researchers argue that traditional theories of animal behavior are theory-laden and fail to consider animals as subjective beings. By drawing on phenomenology, enaction theory, and constructivist psychology, the researchers propose a first-person approach to studying animal behavior. They also suggest combining this perspective with the notion of participatory sense-making to develop a theory of emotional hybridization and explore issues such as human-animal communication. The study has been peer-reviewed and offers a new perspective on understanding animal behavior. [Extracted from the article]

A recent study conducted at the Gynecology-Obstetrics Unit of the University Hospital of the Conception in Marseille, France, compared laparoendoscopic single-site surgery (LESS) to conventional laparoscopy (CL) in the treatment of benign adnexal surgery. The study found that patients in both groups reported similar levels of pain at 24 hours, with no significant differences in postoperative pain at 2 hours, 4 hours, 6 hours, and 7 days. The only difference observed was a longer operating time in the LESS group. Patients' satisfaction with their scar at 1 month may be higher with LESS than with CL. The study was published in the Journal of Minimally Invasive Gynecology. [Extracted from the article]

A recent report from Hospital de la Conception in Marseille, France, highlights a case of a 71-year-old woman with a rare form of sarcoma in the nasal and sinus cavities. The sarcoma featured an internal tandem duplication (ITD) of the BCL6 corepressor (BCOR) gene, which is typically associated with pediatric Ewing-like small round-cell sarcomas. This case expands the understanding of sarcoma and emphasizes the need for further research into the molecular biology of these rare tumors. The patient achieved remission after receiving chemotherapy, suggesting potential therapeutic options for BCOR ITD sarcomas. [Extracted from the article]

A study conducted by the Institute Paoli-Calmettes in Marseille, France, examined the impact of spliceosome gene mutations in patients with acute myeloid leukemia (AML) who were treated with Venetoclax and Azacitidine. The study found that patients with spliceosome mutations, particularly SRSF2 mutations, had poorer outcomes and lower 18-month leukemia-free survival rates. The researchers suggest that further studies should be conducted to address this negative impact. This research has been peer-reviewed and published in Leukemia Research. [Extracted from the article]

Researchers from Aix-Marseille University have conducted a study on diagnostic staging and stratification in psychiatry and oncology. Diagnostic staging involves capturing how diseases progress over time, while stratification identifies different subgroups based on specific markers. The researchers argue that diagnostic staging should be detached from the assumption of temporal determinism and should play a role in adapting interventions to different stages. They suggest that adopting a transdiagnostic and cross-cutting perspective on temporality and disease dynamics can help combine staging and stratification in clinical practice. This research has been peer-reviewed and provides valuable insights for both fields. [Extracted from the article]

A recent study conducted by researchers at Aix-Marseille University in Marseille, France, has shed light on the underlying causes of Charcot-Marie-Tooth (CMT) disease, a common inherited neurological disorder. The study found that an imbalance in the Nrg1-erbb2/3 signaling pathway, which is responsible for myelination in the peripheral nervous system, is linked to aberrant myelination in CMT4H, a demyelinating form of CMT disease. The researchers also identified a potential therapeutic strategy for reducing CMT4H pathology by modulating the Nrg1-erbb2/3 pathway. This research provides valuable insights into the mechanisms of CMT disease and offers potential avenues for future treatment options. [Extracted from the article]

A recent report from Aix-Marseille University discusses research on familial hypobetalipoproteinemias (FHBL), which are rare genetic diseases characterized by lipid malabsorption. The study focused on two specific types of FHBL caused by mutations in the MTTP and SAR1B genes. The researchers evaluated carotenoid absorption and status in FHBL patients and found significant deficiencies in carotenoid plasma levels compared to control subjects. The study suggests that carotenoid supplementation may be beneficial for patients with FHBL to prevent visual impairment. Further research is needed to explore the correlation between carotenoid status and visual function in aging patients. [Extracted from the article]

A recent study conducted by researchers at Aix-Marseille University in Marseille, France, explores the relationship between environmental factors, specifically chemicals, and rare genetic diseases. The researchers developed a Python package called ODAMNet, which offers three different bioinformatics approaches for investigating the connections between chemicals and rare diseases. The package allows for systematic analysis and the generation of hypotheses for further research into the mechanisms of these effects. The study was supported by the European Union and the French Investments for the Future Programme. [Extracted from the article]

A recent report from Aix-Marseille University in France discusses the use of machine learning and mathematical modeling to study metastatic breast cancer after neoadjuvant treatment. The researchers used a mouse model to develop a predictive mathematical model of treatment response and found that neoadjuvant treatment with a receptor tyrosine kinase inhibitor (RTKI) inhibited primary tumor growth but had limited efficacy in preventing metastatic disease progression after surgery. The study also identified the limited power of several biomarkers in predicting metastatic outcomes. The findings highlight the importance of preclinical modeling studies and suggest a potential strategy for assessing future clinical biomarkers. [Extracted from the article]

A recent study conducted at Aix-Marseille University in Marseille, France, focused on surgical site infections (SSIs) in postcaesarean patients in Annaba, Algeria. The study aimed to estimate the frequency of these infections, identify the clinical characteristics associated with them, and determine the antibiotic resistance profile of the bacteria causing the infections. Among 1,810 patients, 36 (1.9%) experienced SSIs, with the majority having undergone emergency deliveries and having a low educational level. The study found that Enterobacteriaceae were the most common bacteria isolated, with Escherichia coli strains being the most prevalent, many of which were carriers of extended-spectrum beta-lactamases. The research concluded that extensive surveillance of at-risk populations is necessary to prevent SSIs. [Extracted from the article]

A recent report from the Public Assistance Hospital of Marseille (AP-HM) in France discusses the use of a combination of axitinib and metronomic etoposide as a potential treatment for relapsed brain tumors in children. The study, based on real-world observations, found that the combination showed signs of efficacy in heavily pretreated patients, with some experiencing partial response or stable disease. However, two patients did experience grade 3-4 toxicities. The researchers suggest that further evaluation in a phase I/II trial is needed to confirm these findings. [Extracted from the article]

A recent report from Aix-Marseille University in Marseille, France discusses a new testing procedure for comparing unknown random sources in two separate samples. The researchers propose a tuning-free relaxed semiparametric test that requires minimal assumptions about the unknown distributions. The study includes an intensive numerical analysis to demonstrate the asymptotic properties of the test. The procedure is then applied to a real-life situation, specifically pairwise post COVID-19 mortality excess profile testing across a panel of European countries. The research has been peer-reviewed and is available for further reading. [Extracted from the article]

A recent study conducted at Nord Marseille Hospital in Marseille, France, focused on lymphadenopathy, a condition characterized by swollen lymph nodes. The researchers presented a case study of a 53-year-old man with inguinal lymphadenopathy that had persisted for over a year. After conducting an excisional biopsy, the researchers diagnosed the patient with intranodal palisaded myofibroblastoma, a rare benign tumor. The study concluded that this type of tumor typically presents in inguinal lymph nodes, grows slowly, and does not recur after surgical removal. The research has been peer-reviewed and published in La Revue de Medecine Interne. [Extracted from the article]

A recent study conducted by investigators at Aix-Marseille University in Marseille, France, examined the frequency of tobacco and cannabis screening by general practitioners (GPs) in France. The study found that 74.6% of GPs systematically screened their patients for tobacco use, while 34.7% screened for cannabis use. The research also identified characteristics associated with more frequent screening, such as being under 50 years of age, working in a group practice, and using the 'early identification and brief intervention' approach. The study concluded that better GP training is necessary to ensure continued improvements in screening frequencies. [Extracted from the article]

New research from Aix-Marseille University in Marseille, France, explores the impact of dust-bound contaminants on human health, particularly in young children who may ingest these contaminants while playing on the ground. The study focuses on the presence of carcinogenic substances, such as metal(loid)s and polycyclic aromatic hydrocarbons (PAHs), in settled dust from preschools in different areas. The researchers found that the bioaccessible fraction of these contaminants represents a potential cancer risk for children. The study suggests that further investigation is needed to complement cancer risk calculations, which currently rely on known toxic substances. [Extracted from the article]