1. The Use of Colistin for the Treatment of Multidrug-resistant Gram-negative Infections in Neonates and Infants
- Author
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Roberto Imberti, Kulkanya Chokephaibulkit, and Narongsak Nakwan
- Subjects
Microbiology (medical) ,medicine.medical_specialty ,medicine.drug_class ,Antibiotics ,03 medical and health sciences ,Route of administration ,0302 clinical medicine ,Pharmacokinetics ,Drug Resistance, Multiple, Bacterial ,030225 pediatrics ,Internal medicine ,medicine ,Ventriculitis ,Humans ,030212 general & internal medicine ,Colistin ,business.industry ,Infant, Newborn ,Infant ,medicine.disease ,Anti-Bacterial Agents ,Treatment Outcome ,Infectious Diseases ,Pediatrics, Perinatology and Child Health ,Adjunctive treatment ,Administration, Intravenous ,Gram-Negative Bacterial Infections ,business ,Meningitis ,Colistimethate ,medicine.drug - Abstract
In this review, we report the available data regarding efficacy, safety and pharmacokinetics of colistin in the treatment of multidrug-resistant Gram-negative bacteria in neonates and infants. Seventeen clinical studies, involving 312 patients, and 3 pharmacokinetics studies were identified. Blood stream infection was the most common source of infection, followed by pneumonia and meningitis/ventriculitis. In most cases, colistin was administered in association with other antibiotics. The most common route of administration was intravenous, with colistimethate doses ranging from 25,000 to 225,000 IU/kg/day divided into 2 or 3 doses. A recent pharmacokinetic study suggested that the appropriate intravenous dose should be >150,000 IU/kg/day. Microbiologic cure was obtained in 94.2% of patients and survival was 76.6%. The combination of intraventricular and intravenous colistin should be used in meningitis/ventriculitis. Nebulized colistin should be used as adjunctive treatment, but not as monotherapy. Nephrotoxicity and apnea were reported in 5.8% and 3.9% of patients respectively.The use of colistin for multidrug-resistant Gram-negative infections in neonates and infants is effective and safe, but the quality of studies is moderate. The optimal intravenous dose should be higher than that indicated in most reports.
- Published
- 2019