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Systemic pharmacokinetics and safety of high doses of nebulized colistimethate sodium in critically ill patients with hospital-acquired and ventilator-associated pneumonia
- Source :
- The Journal of antimicrobial chemotherapy. 74(11)
- Publication Year :
- 2019
-
Abstract
- Objectives To assess the pharmacokinetics of formed colistin in plasma and the safety of two different high doses of colistimethate sodium administered via nebulization in critically ill surgical patients with hospital-acquired pneumonia (HAP) or ventilator-associated pneumonia (VAP). Patients and methods Formed colistin plasma concentrations were measured in critically ill surgical patients with pneumonia treated with two different doses of nebulized colistimethate sodium (3 MIU/8 h versus 5 MIU/8 h). Adverse events possibly related to nebulized colistimethate sodium were recorded. Results Twenty-seven patients (15 in the 3 MIU/8 h group and 12 in the 5 MIU/8 h group) were included. Colistin plasma concentrations were unquantifiable ( Conclusions In this limited observational case series of critically ill patients with HAP or VAP treated with high doses of nebulized colistimethate sodium, systemic exposure was minimal and the treatment was well tolerated.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
Male
Critical Illness
030106 microbiology
03 medical and health sciences
0302 clinical medicine
Pharmacokinetics
Administration, Inhalation
Pneumonia, Bacterial
Medicine
Humans
Pharmacology (medical)
Prospective Studies
Adverse effect
Prospective cohort study
Aged
Pharmacology
Aged, 80 and over
Inhalation
business.industry
Colistin
Nebulizers and Vaporizers
Ventilator-associated pneumonia
Pneumonia, Ventilator-Associated
030208 emergency & critical care medicine
Middle Aged
medicine.disease
Anti-Bacterial Agents
Pneumonia
Infectious Diseases
Anesthesia
Female
business
medicine.drug
Colistimethate
Subjects
Details
- ISSN :
- 14602091
- Volume :
- 74
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- The Journal of antimicrobial chemotherapy
- Accession number :
- edsair.doi.dedup.....3d922d676ba1e276f863f1aae44e437e