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Association between the introduction of a new cystic fibrosis inhaled antibiotic class and change in prevalence of patients receiving multiple inhaled antibiotic classes
- Source :
- Journal of Cystic Fibrosis. 14:370-375
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Background In 2010, aztreonam for inhalation solution joined aminoglycosides and colistimethate as a new cystic fibrosis (CF) chronic inhaled antimicrobial therapy. We studied how the introduction of this new inhaled antibiotic class changed the management of US CF patients. Methods The use of inhaled aminoglycosides, colistimethate, and aztreonam among patients followed in the CF Foundation Patient Registry was analyzed by age group, lung disease stage, and microbiologic status both annually, and at individual visits between 2009 and 2012. Results The overall prevalence of inhaled antibiotic use did not change during the period, but the prevalence of annual and any visit treatment with >1 inhaled antibiotic class more than doubled. Adults, those with advanced lung disease, and those with >1 Pseudomonas aeruginosa respiratory culture were more likely to receive >1 antibiotic class. Conclusions Inhaled antibiotic management of US CF patients has dramatically changed in association with the introduction of a third inhaled antibiotic class.
- Subjects :
- Adult
Male
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Adolescent
Cystic Fibrosis
medicine.drug_class
Antibiotics
Aztreonam
medicine.disease_cause
Cystic fibrosis
Article
Young Adult
chemistry.chemical_compound
Internal medicine
Administration, Inhalation
Prevalence
Tobramycin
Humans
Medicine
Pseudomonas Infections
Child
Intensive care medicine
Retrospective Studies
Aerosols
Colistin
business.industry
Pseudomonas aeruginosa
Retrospective cohort study
medicine.disease
Anti-Bacterial Agents
Treatment Outcome
chemistry
Pediatrics, Perinatology and Child Health
Drug Therapy, Combination
Female
business
Follow-Up Studies
medicine.drug
Colistimethate
Subjects
Details
- ISSN :
- 15691993
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Journal of Cystic Fibrosis
- Accession number :
- edsair.doi.dedup.....ffa8781cb54bf9add6bf8c6ab62aaa45