Back to Search
Start Over
N-acetylcysteine suppresses colistimethate sodium-induced nephrotoxicity via activation of SOD2, eNOS, and MMP3 protein expressions
- Source :
- Renal Failure, Renal Failure, Vol 40, Iss 1, Pp 423-434 (2018)
- Publication Year :
- 2018
-
Abstract
- WOS: 000439906200002 PubMed ID: 30035652 Objective: To investigate the molecular mechanisms of colistimethate sodium-induced nephrotoxicity and the protective effect of N-acetylcysteine (NAC) against nephrotoxicity.Methods: Twenty-eight Wistar rats were divided into four groups comprised of control, colistin, NAC, and colistin-NAC co-treatment, respectively. Serum creatinine and urine N-acetyl--d-glucosaminidase (NAG) levels were measured at different time intervals. Histological changes, apoptosis, total oxidant and antioxidant status, and the expression levels of endothelial nitric oxide synthase (eNOS), superoxide dismutase 2 (SOD2), and matrix metalloproteinase 3 (MMP3) were evaluated in renal tissue.Results: In the colistin group, post-treatment creatinine levels were higher than pretreatment levels (p=.001). There was a significant increase in urine NAG level following colistin treatment on day 10, compared to the baseline value and the first day of treatment (p=.001 and .0001, respectively). Urine NAG levels were higher in the colistin group on the 10th day of treatment than in the other groups (p
- Subjects :
- Male
0301 basic medicine
Antioxidant
Ceylan B., Ozansoy M., Kılıç Ü., Yozgat Y., Ercan Ç., Yıldız P., Aslan T., -N-acetylcysteine suppresses colistimethate sodium-induced nephrotoxicity via activation of SOD2, eNOS, and MMP3 protein expressions.-, Renal failure, cilt.40, ss.423-434, 2018
Nitric Oxide Synthase Type III
medicine.medical_treatment
030106 microbiology
SOD2
Pharmacology
lcsh:RC870-923
Kidney
Critical Care and Intensive Care Medicine
Nephrotoxicity
Acetylcysteine
03 medical and health sciences
Enos
Laboratory Study
Acetylglucosaminidase
Animals
Humans
Medicine
Rats, Wistar
reactive oxygen species
chemistry.chemical_classification
Reactive oxygen species
biology
Colistin
Superoxide Dismutase
business.industry
nephrotoxicity
rat model
Free Radical Scavengers
General Medicine
Acute Kidney Injury
lcsh:Diseases of the genitourinary system. Urology
biology.organism_classification
Rats
Disease Models, Animal
chemistry
Nephrology
Creatinine
Matrix Metalloproteinase 3
business
medicine.drug
Colistimethate
Subjects
Details
- ISSN :
- 00043990
- Database :
- OpenAIRE
- Journal :
- Renal Failure, Renal Failure, Vol 40, Iss 1, Pp 423-434 (2018)
- Accession number :
- edsair.doi.dedup.....e7bab1f4ac84ef7794286036cc78e689