1. The use of a gene expression signature and connectivity map to repurpose drugs for bipolar disorder
- Author
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Tamsyn M. Crowley, Bruna Panizzutti, Marion Leboyer, Elizabeth Scarr, Laura J. Gray, Timothy Connor, Srisaiyini Kidnapillai, Olivia M Dean, Madhara Udawela, Michael Berk, Stéphane Jamain, Andrew Sanigorski, Briana Spolding, Ken Walder, Brian Dean, and Chiara C. Bortolasci
- Subjects
Bipolar Disorder ,Expression Signature ,Computational biology ,Lamotrigine ,Transcriptome ,Quetiapine Fumarate ,03 medical and health sciences ,0302 clinical medicine ,Animals ,Medicine ,Bipolar disorder ,Gene ,Biological Psychiatry ,business.industry ,Drug discovery ,Drug Repositioning ,medicine.disease ,Rats ,030227 psychiatry ,Psychiatry and Mental health ,Drug repositioning ,Pharmaceutical Preparations ,business ,medicine.drug - Abstract
To create a gene expression signature (GES) to represent the biological effects of a combination of known drugs for bipolar disorder (BD) on cultured human neuronal cells (NT2-N) and rat brains, which also has evidence of differential expression in individuals with BD. To use the GES to identify new drugs for BD using Connectivity Map (CMap).
- Published
- 2018