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The effect of dietary energy restriction on body weight gain and the development of noninsulin-dependent diabetes mellitus (NIDDM) in Psammomys obesus
- Source :
- Obesity research. 5(3)
- Publication Year :
- 1997
-
Abstract
- Food intake was restricted to 75% of ad libitum levels in 37 male Psammomys obesus (Israeli Sand Rats) from the ages of 4 (weaning) to 10 weeks. Energy restriction reduced the mean bodyweight at 10 weeks by 29% compared with 44 ad libitum fed controls. Hyperglycemia was prevented completely in the food-restricted group, and mean blood glucose concentrations were significantly reduced (3.8 +/- 0.2 vs. 5.5 +/- 0.4 mumol/L; p < 0.05) compared with control animals. Plasma insulin concentrations were also decreased significantly compared with ad libitum fed controls (105 +/- 13 vs. 241 +/- 29 mU/L; p < 0.05). Although energy restriction prevented hyperglycemia from developing in 10-week-old P. obesus, 19% of the food restricted animals still developed hyperinsulinemia. We concluded that hyperphagia between the ages of 4 to 10 weeks may be essential for the development of noninsulin-dependent diabetes mellitus in P. obesus, but that hyperinsulinemia may still occur in the absence of hyperphagia and hyperglycemia, suggesting a significant genetic influence on the development of hyperinsulinemia in this animal model.
- Subjects :
- Male
medicine.medical_specialty
Food intake
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
Hyperphagia
Body weight
Weight Gain
Eating
Endocrinology
Animal model
Internal medicine
Diabetes mellitus
medicine
Hyperinsulinemia
Weaning
Animals
biology
business.industry
digestive, oral, and skin physiology
Public Health, Environmental and Occupational Health
Non insulin dependent diabetes mellitus
nutritional and metabolic diseases
medicine.disease
biology.organism_classification
Diet
Diabetes Mellitus, Type 2
Hyperglycemia
Female
Psammomys
Insulin Resistance
business
Energy Intake
Gerbillinae
Food Science
Subjects
Details
- ISSN :
- 10717323
- Volume :
- 5
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Obesity research
- Accession number :
- edsair.doi.dedup.....6dc3e19eb81d8e0a84420adedc6d8dea