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Effect of feeding quandong (santalum acuminatum) oil to rats on tissue lipids, hepatic cytochrome P-450 and tissue histology
- Source :
- Food and Chemical Toxicology. 32:521-525
- Publication Year :
- 1994
- Publisher :
- Elsevier BV, 1994.
-
Abstract
- Quandong kernels are a traditional Aboriginal food item; they are rich in oil and contain large amounts of an unusual fatty acid, trans-11-octadecen-9-ynoic acid (santalbic acid), but it is not known whether this acid is absorbed and/or metabolized. The oil was fed at 12.6% of total energy content in semi-synthetic diets to groups of male Sprague-Dawley rats for 10 and 20 days. Santalbic acid was found in the lipids of plasma, adipose tissue, skeletal muscle, kidney, heart and liver but not in brain. Hepatic microsomal cytochrome P-450 activity in animals fed for 20 days was significantly higher (P < 0.05) than in controls. Histopathological examination did not reveal any lesions in the tissues of any animal fed quandong oil. The fact that santalbic acid was readily absorbed, widely distributed in tissues and was associated with an elevated level of hepatic cytochrome P-450 indicates that further studies are required to investigate whether or not there is a hazard associated with the human practice of consuming quandong kernels.
- Subjects :
- Male
medicine.medical_specialty
Cytochrome
Adipose tissue
Oleic Acids
Kidney
Toxicology
Rats, Sprague-Dawley
Random Allocation
Cytochrome P-450 Enzyme System
Dietary Fats, Unsaturated
Internal medicine
medicine
Animals
Plant Oils
Tissue Distribution
Santalum acuminatum
chemistry.chemical_classification
biology
Muscles
Myocardium
Fatty Acids
Cytochrome P450
Fatty acid
Heart
Histology
General Medicine
Lipid Metabolism
biology.organism_classification
Lipids
Rats
Endocrinology
Adipose Tissue
Liver
Biochemistry
chemistry
Toxicity
Microsome
biology.protein
Food Science
Subjects
Details
- ISSN :
- 02786915
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Food and Chemical Toxicology
- Accession number :
- edsair.doi.dedup.....9a3ee152f276ad6aeb57073d8e9b8af3