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Leptin resistance in a polygenic, hyperleptinemic animal model of obesity and NIDDM: Psammomys obesus
- Source :
- International Journal of Obesity. 23:83-89
- Publication Year :
- 1999
- Publisher :
- Springer Science and Business Media LLC, 1999.
-
Abstract
- Objective To investigate the effects of leptin administration to Psammomys obesus, a polygenic animal model of obesity and type 2 diabetes mellitus. Design Longitudinal intervention study utilising three separate leptin treatment protocols lasting 7-14 d. Measurements Body weight and food intake were measured daily, body fat and muscle content were estimated by carcass analysis on completion of the study. Blood glucose, plasma insulin, leptin, triglycerides and cholesterol were measured at baseline and twice each week during the study. Results Relatively high doses of leptin were required to significantly reduce food intake and body fat content in lean Psammomys obesus, but had no discernible effect on their obese littermates. Conclusion As a species, Psammomys obesus appear to be relatively insensitive to the effects of leptin administration, compared with other rodents. Obese Psammomys obesus are leptin resistant relative to their lean littermates.
- Subjects :
- Blood Glucose
Leptin
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Medicine (miscellaneous)
Eating
chemistry.chemical_compound
Animal model
Internal medicine
Diabetes mellitus
Diabetes Mellitus
medicine
Animals
Insulin
Obesity
Triglycerides
Nutrition and Dietetics
biology
business.industry
Cholesterol
Body Weight
digestive, oral, and skin physiology
Proteins
Type 2 Diabetes Mellitus
biology.organism_classification
medicine.disease
Disease Models, Animal
Endocrinology
Diabetes Mellitus, Type 2
chemistry
Psammomys
Energy Intake
Gerbillinae
business
Subjects
Details
- ISSN :
- 14765497 and 03070565
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- International Journal of Obesity
- Accession number :
- edsair.doi.dedup.....91c304dd6a4e8677e8f37e1721962496