1. Levodopa‐Carbidopa Intestinal Gel Reduces Dyskinesia in Parkinson's Disease in a Randomized Trial
- Author
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Eero Pekkonen, Egon Kurča, P. Vanni, Eric Freire-Alvarez, Luigi M Barbato, Cleanthe Spanaki, Yang Liu, Olga Sanchez-Soliño, and Lydia Lopez Manzanares
- Subjects
medicine.medical_specialty ,Parkinson's disease ,Movement disorders ,law.invention ,Antiparkinson Agents ,Levodopa ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,Quality of life ,Rating scale ,law ,Internal medicine ,Activities of Daily Living ,medicine ,Humans ,Adverse effect ,030304 developmental biology ,0303 health sciences ,Dyskinesias ,business.industry ,Carbidopa ,Parkinson Disease ,medicine.disease ,3. Good health ,Drug Combinations ,Neurology ,Dyskinesia ,Quality of Life ,Levodopa carbidopa ,Neurology (clinical) ,medicine.symptom ,business ,Gels ,030217 neurology & neurosurgery - Abstract
BACKGROUND There are limited data regarding the effectiveness of levodopa-carbidopa intestinal gel (LCIG) for dyskinesia. OBJECTIVE Compare the effectiveness of LCIG versus oral optimized medical treatment (OMT) for dyskinesia in patients with advanced Parkinson's disease (PD) using the Unified Dyskinesia Rating Scale (UDysRS). METHODS This phase 3b, open-label, multicenter, 12-week, interventional study (NCT02799381) randomized 63 LCIG naive patients with advanced PD (UDysRS ≥30) to LCIG (N = 30) or OMT (N = 33) treatment. Dyskinesia impact was assessed at baseline through week 12 using the UDysRS. PD-related motor and non-motor symptoms, and quality of life (QoL) were also assessed. RESULTS Dyskinesias measured by UDysRS were significantly reduced in the LCIG group (n = 24; -17.37 ± 2.79) compared with the OMT group (n = 26; -2.33 ± 2.56) after 12 weeks (-15.05 ± 3.20; 95% CI, -21.47 to -8.63; P
- Published
- 2021