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Deep brain stimulation for monogenic Parkinson’s disease: a systematic review
- Source :
- Journal of Neurology
- Publication Year :
- 2019
- Publisher :
- Springer Berlin Heidelberg, 2019.
-
Abstract
- Deep brain stimulation (DBS) is an effective treatment for Parkinson’s disease (PD) patients with motor fluctuations and dyskinesias. The key DBS efficacy studies were performed in PD patients with unknown genotypes; however, given the estimated monogenic mutation prevalence of approximately 5–10%, most commonly LRRK2, PRKN, PINK1 and SNCA, and risk-increasing genetic factors such as GBA, proper characterization is becoming increasingly relevant. We performed a systematic review of 46 studies that reported DBS effects in 221 genetic PD patients. The results suggest that monogenic PD patients have variable DBS benefit depending on the mutated gene. Outcome appears excellent in patients with the most common LRRK2 mutation, p.G2019S, and good in patients with PRKN mutations but poor in patients with the more rare LRRK2 p.R1441G mutation. The overall benefit of DBS in SNCA, GBA and LRRK2 p.T2031S mutations may be compromised due to rapid progression of cognitive and neuropsychiatric symptoms. In the presence of other mutations, the motor changes in DBS-treated monogenic PD patients appear comparable to those of the general PD population. Electronic supplementary material The online version of this article (10.1007/s00415-019-09181-8) contains supplementary material, which is available to authorized users.
- Subjects :
- medicine.medical_specialty
Parkinson's disease
Neurology
Deep brain stimulation
Monogenic
medicine.medical_treatment
Deep Brain Stimulation
Population
PINK1
Disease
Review
Bioinformatics
medicine.disease_cause
03 medical and health sciences
0302 clinical medicine
Genetic
Outcome Assessment, Health Care
medicine
Humans
030212 general & internal medicine
education
education.field_of_study
Mutation
Parkinson’s disease
Neurology (clinical)
business.industry
Parkinson Disease
medicine.disease
LRRK2
3. Good health
nervous system diseases
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 14321459 and 03405354
- Volume :
- 267
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of Neurology
- Accession number :
- edsair.doi.dedup.....06688386f5ada80fa523929c41dc2900