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Spontaneous sensorimotor cortical activity is suppressed by deep brain stimulation in patients with advanced Parkinson's disease
- Source :
- NEUROSCIENCE LETTERS. 683:48-53
- Publication Year :
- 2018
-
Abstract
- Advanced Parkinson's disease (PD) is characterized by an excessive oscillatory beta band activity in the sub thalamic nucleus (STN). Deep brain stimulation (DBS) of STN alleviates motor symptoms in PD and suppresses the STN beta band activity. The effect of DBS on cortical sensorimotor activity is more ambiguous; both increases and decreases of beta band activity have been reported. Non-invasive studies with simultaneous DBS are problematic due to DBS-induced artifacts. We recorded magnetoencephalography (MEG) from 16 advanced PD patients with and without STN DBS during rest and wrist extension. The strong magnetic artifacts related to stimulation were removed by temporal signal space separation. MEG oscillatory activity at 5-25 Hz was suppressed during DBS in a widespread frontoparietal region, including the sensorimotor cortex identified by the cortico-muscular coherence. The strength of suppression did not correlate with clinical improvement. Our results indicate that alpha and beta band oscillations are suppressed at the frontoparietal cortex by STN DBS in PD.
- Subjects :
- Male
Parkinson's disease
medicine.medical_treatment
Stimulation
Electroencephalography
Subthalamic nucleus
3124 Neurology and psychiatry
0302 clinical medicine
Cortex (anatomy)
Deep brain stimulation
Beta Rhythm
EEG
MU-RHYTHM
medicine.diagnostic_test
General Neuroscience
05 social sciences
Magnetoencephalography
Parkinson Disease
MUSCULAR COHERENCE
Middle Aged
STATE
Alpha Rhythm
surgical procedures, operative
medicine.anatomical_structure
Female
Sensorimotor Cortex
therapeutics
Adult
TREMOR
CORTEX
behavioral disciplines and activities
ta3112
050105 experimental psychology
03 medical and health sciences
Beta band suppression
OSCILLATIONS
medicine
Humans
0501 psychology and cognitive sciences
SIGNAL SPACE SEPARATION
Aged
business.industry
3112 Neurosciences
medicine.disease
nervous system diseases
Advanced Parkinson's disease
nervous system
business
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 03043940
- Volume :
- 683
- Database :
- OpenAIRE
- Journal :
- NEUROSCIENCE LETTERS
- Accession number :
- edsair.doi.dedup.....3ec367d4bed958915ec984e8a527fc23