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Ambulatory surface electromyography with accelerometry for evaluating daily motor fluctuations in Parkinson’s disease
- Source :
- Clinical Neurophysiology. 132:469-479
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Objective To evaluate motor fluctuations in patients with advanced Parkinson’s disease (PD) using a small-sized wearable device for surface electromyography (EMG) with accelerometry (ACC) for 24 hours. Methods Seven PD patients with medication were measured once, and nine patients with directional deep brain stimulation (dDBS) twice: before and after the dDBS reprogramming. EMG and ACC parameters were compared with clinical rating scores and patients’ home diaries. Results The combination of EMG and ACC parameters (first principal component PC1) correlated significantly with patient’s condition as quantified by the motor score of Unified Parkinson’s Disease Rating Scale and it changed significantly with dDBS reprogramming in line with decreased PD symptoms. Monitoring data detected in comparison with the home diaries: 91 % concordance with tremor, 76 % with rigidity, and 74 % with dyskinesia. In the DBS group, the wake-up time with abnormal neuromuscular function was reduced with reprogramming in all except one patient based on measurements. Conclusions A wearable device measuring simultaneously both muscle activity and motion can provide continuous and dynamic information about patient’s condition and motor fluctuations at home. Significance The present method may help to modify pharmacologic management and DBS treatment in advanced PD.
- Subjects :
- Adult
Male
medicine.medical_specialty
Parkinson's disease
Deep brain stimulation
Deep Brain Stimulation
Movement
medicine.medical_treatment
Concordance
0206 medical engineering
Monitoring, Ambulatory
02 engineering and technology
Electromyography
Accelerometer
Wearable Electronic Devices
03 medical and health sciences
0302 clinical medicine
Physical medicine and rehabilitation
Rating scale
Physiology (medical)
Accelerometry
medicine
Humans
Aged
medicine.diagnostic_test
business.industry
Parkinson Disease
Middle Aged
medicine.disease
020601 biomedical engineering
Sensory Systems
Neurology
Dyskinesia
Ambulatory
Female
Neurology (clinical)
medicine.symptom
business
030217 neurology & neurosurgery
Muscle Contraction
Subjects
Details
- ISSN :
- 13882457
- Volume :
- 132
- Database :
- OpenAIRE
- Journal :
- Clinical Neurophysiology
- Accession number :
- edsair.doi.dedup.....3cb0411b9b76b8dc533017963c63ae2b