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A recent report from Nagasaki University in Japan discusses the role of proline-rich transmembrane protein 2 (PRRT2) in paroxysmal kinesigenic dyskinesia (PKD). The study found that a mutation in PRRT2 exacerbated motor deficits in mice treated with L-dopa, suggesting a potential link between the basal ganglia and PKD pathology. The researchers also discovered that the PRRT2 mutation enhanced dopamine release in the mouse striatum, which was attenuated by repeated stimulation. These findings suggest that the enhanced and prolonged responsiveness of dopamine release may contribute to Prrt2-related dyskinesia. [Extracted from the article]

A recent study conducted by the University of Geneva explores the role of the medial prefrontal cortex (mPFC) to ventral tegmental area (VTA) pathway in controlling impulsive action and risk-related decision-making (RDM) in rats. The researchers used a chemogenetic strategy to selectively activate or inhibit this pathway in Roman High- and Low-Avoidance rats, which exhibit innate differences in impulsive action and RDM. The results showed that activating the mPFC-to-VTA pathway reduced impulsive action in high-avoidance rats, while inhibiting it had the opposite effect in low-avoidance rats. However, these manipulations did not affect RDM. The findings suggest that the mPFC-to-VTA pathway plays a dissociable role in impulsive action and RDM, highlighting its potential as a target for investigating impulsivity-related disorders. [Extracted from the article]

A report from Dokkyo Medical University in Tochigi, Japan discusses the use of photopharmacology to modulate biological phenomena through the photoconversion of substances in a specific target region at precise times. The researchers investigated the application of a microscale light-emitting diode (MicroLED) probe for the photoconversion of caged-glutamate (caged-Glu) in vivo. They found that the MicroLED probe was effective in modulating the local field potential (LFP) with caged-Glu in the mouse hippocampal dentate gyrus (DG). This research provides insights into the potential use of photopharmacology in neuropsychopharmacology. [Extracted from the article]

A recent study conducted by the Kobe University Graduate School of Medicine in Japan examined the impact of internet gaming disorder (IGD) on patients. The researchers analyzed various factors including internet or gaming dependence, developmental problems, family background, severity of depression, sleeping habits, in-game spending, and first-person shooter (FPS) and third-person shooter (TPS) game playing. The study found that violent gameplay and in-game spending were significantly associated with IGD in male patients. The researchers suggest that reducing both violent game playing and in-game spending could have synergistic effects in treating IGD. They emphasize the importance of considering individualized environmental adjustments and providing psychotherapy for internet dependence. [Extracted from the article]

A recent study conducted by researchers at the Complutense University of Madrid explored the relationship between alcohol use disorder (AUD), inflammation, and cognitive decline. The study involved a cross-sectional analysis of abstinent AUD patients and healthy controls, examining plasma apolipoproteins and inflammatory markers. The findings revealed that higher levels of certain apolipoproteins and proinflammatory markers were observed in the AUD group, while levels of APOM were lower. The study suggests that APOAI and APOM play divergent roles in identifying AUD and their associations with inflammation and cognitive decline. [Extracted from the article]

A recent report from Karl-Franzens-University in Graz, Austria, discusses the findings of a neuro-psychopharmacology study on skin-picking disorder (SPD). The study aimed to understand the neuroanatomical aspects of SPD, which is characterized by excessive skin manipulation leading to skin lesions and psychological distress. The study involved 220 participants, including patients with SPD and healthy controls, and used voxel-based morphometry (VBM) to compare brain volume between groups. The results showed that patients with SPD had less grey matter volume in specific brain regions involved in interoception, emotion regulation, and motor control. The study also found that early onset of symptoms was associated with more focused skin-picking and additional reductions in grey matter volume. The research concludes that further investigation is needed to understand the heterogeneity of the disorder. [Extracted from the article]

A recent study conducted at the University of the Ryukyus in Okinawa, Japan, has found that guanfacine, a medication used to treat attention deficit hyperactivity disorder (ADHD), may be effective in improving cognitive functioning in long-COVID patients experiencing cognitive impairment. The study focused on a 32-year-old woman who experienced difficulty with word recall, reading, writing, and multitasking after recovering from COVID-19. The woman's cognitive abilities significantly improved after being treated with guanfacine, as measured by various tests and brain imaging. The researchers suggest that guanfacine could be a potential treatment option for long-COVID patients with cognitive impairment. [Extracted from the article]

A recent study conducted by the Institute of Cognitive Neuroscience and Psychology in Budapest, Hungary, explores the relationship between slow-wave activity (SWA) during non-rapid eye movement (NREM) sleep and attention deficit hyperactivity disorder (ADHD) in adolescents. The study found that medication-naive adolescents at-risk for ADHD exhibited higher levels of NREM SWA compared to both medicated adolescents at-risk for ADHD and adolescents not at-risk for ADHD. This suggests that greater NREM SWA may be a compensatory mechanism in at-risk adolescents that normalizes a developmental delay. The study highlights the potential role of pharmacotherapy in normalizing cortical maturation in ADHD. [Extracted from the article]

A recent report from Keio University School of Medicine in Tokyo, Japan discusses the development of a Japanese version of the Challenging Experience Questionnaire (CEQ). The CEQ is used to assess challenging experiences during psychedelic-assisted therapy. The study followed a translation and cultural adaptation process to create the Japanese version of the CEQ. Further research is needed to evaluate the reliability and validity of this newly translated version. This information may be useful for individuals interested in the therapeutic potential of psychedelics for mental disorders. [Extracted from the article]

A recent report from Mazandaran University of Medical Sciences in Sari, Iran discusses the neuropsychiatric effects of anticholinergic agents and anabolic steroids. The study highlights the importance of understanding these effects for emergency clinicians, as symptoms can include anxiety, confusion, hallucinations, and coma. The report presents four cases of individuals who experienced neuropsychiatric manifestations after ingesting bodybuilding powders with anticholinergic properties. Laboratory analysis revealed that the powders contained anabolic steroids and cyproheptadine. This research provides valuable insights into the potential dangers of these substances. [Extracted from the article]

A recent study conducted at Autonomous University Madrid explored the impact of risky alcohol use during youth on emotion, cognitive networks, and resting-state EEG activity. The study involved 82 college students between the ages of 18 and 25, with 40 healthy control participants and 42 participants with risky alcohol use. The findings revealed that those in the risky alcohol use group exhibited higher emotional dysregulation and impulsivity traits, as well as worse functioning in cognitive domains such as sustained attention, verbal memory, and executive functions. However, there were no significant differences in resting-state EEG activity between the two groups. The study emphasizes the importance of further investigating the emotional, cognitive, and brain changes associated with risky alcohol use in young people. [Extracted from the article]

Researchers from Peking University in Beijing, China have conducted a study on the role of the trace amine-associated receptor 1 (TAAR1) in chronic stress-induced impairments in hippocampal plasticity and cognitive function. The study used genetic approaches, behavioral tests, and immunohistochemical staining to investigate the effects of TAAR1 on dentate neuronal plasticity and cognitive function in mice subjected to chronic social defeat stress. The results showed that chronic stress led to decreased TAAR1 levels in the dentate gyrus, as well as compromised social memory, impaired proliferation and maturation of adult-born dentate granule cells, and cognitive function deficits. However, the administration of a selective TAAR1 partial agonist attenuated these adverse effects. The researchers concluded that TAAR1 agonists may have therapeutic potential for individuals with cognitive impairments associated with major depressive disorder. [Extracted from the article]

Researchers from Technical University Dresden (TU Dresden) have conducted a study on the effects of catecholaminergic and transcranial direct current stimulation (tDCS) on response inhibition. The study involved administering methylphenidate (MPH) and anodal tDCS over the right inferior frontal gyrus to healthy adult participants. The results showed that both MPH and tDCS likely share a common underlying neuronal mechanism, and when combined, they demonstrated interactive effects. This study provides important groundwork for future applications of MPH and non-invasive brain stimulation. The research was published in the International Journal of Neuropsychopharmacology. [Extracted from the article]

A recent study conducted at Hiroshima International University in Japan aimed to identify subgroups of patients with alcohol use disorder (AUD) based on a combination of alexithymia, depression, and diverse drinking behavior. The study recruited 176 patients with AUD and divided them into non-alexithymic and alexithymic groups. The results showed that patients with alexithymia exhibited greater depressive symptoms and more pathological drinking behavior patterns compared to those without alexithymia. Cluster analysis identified three subtypes of AUD: core AUD type, late-onset type, and alexithymic type. The study suggests that the alexithymic subtype may require additional support for negative affect due to accompanying mood problems and maladaptive drinking behaviors. [Extracted from the article]

A systematic review conducted by the Shiraz University of Medical Sciences in Iran examined the effects of prebiotics, probiotics, and synbiotics on children with attention deficit hyperactivity disorder (ADHD). The review analyzed seven randomized controlled trials and two cohort studies and found that probiotic supplementation, specifically Lactobacillus rhamnosus GG (LGG), improved emotional, physical, social, and school functioning in children with ADHD compared to a placebo group. Additionally, the use of synbiotic 2000 reduced markers of intestinal and vascular inflammation in children with ADHD. However, further studies with longer duration and larger sample sizes are needed to fully understand the effects of prebiotics and probiotics on ADHD. [Extracted from the article]

A recent study conducted by researchers at the Karolinska Institute in Solna, Sweden compared two potential antipsychotic drugs, ulotaront and ralmitaront. Ulotaront, which has reached Phase II clinical trials, demonstrated efficacy, while ralmitaront did not show efficacy as a monotherapy or adjunct to atypical antipsychotics. The study found that ralmitaront had lower efficacy and slower kinetics at the trace amine-associated receptor-1 (TAAR1) and lacked efficacy at the serotonin 1A receptor (5-HT1AR) and dopamine D-2. These findings may help explain the differences in the clinical profiles of these two compounds. [Extracted from the article]

New research published in Neuropsychopharmacology Reports suggests that taking probiotics and vitamin D supplements may improve cognitive function in individuals with schizophrenia. The study involved 70 adults with schizophrenia who were randomized to receive either a placebo or probiotic supplements plus 400 IU of vitamin D daily for 12 weeks. The results showed that the group taking the probiotic-containing supplement had an increase in cognitive function compared to the placebo group. The researchers believe that probiotics may be a novel way to treat mental disorders by regulating gut microbiota. [Extracted from the article]

A recent study conducted by researchers at the University of Sao Paulo in Brazil explores the therapeutic potential of psychedelics in the field of neuro-psychopharmacology. Psychedelics are psychoactive substances that can alter perception, mood, and cognitive functions by activating 5-HT2A receptors. The study highlights the promising findings in the literature regarding the therapeutic effects of psychedelics, particularly in the treatment of disorders such as depression, addiction, anxiety, and post-traumatic stress disorder. Despite the increasing number of studies reporting clinical effectiveness and minimal side effects, there is still much to be understood about the relationship between these drugs and the human brain. [Extracted from the article]

A recent report from the Psychology & Psychiatry Journal discusses research conducted at the Western University of Health Sciences on the effects of small-molecule NOP agonists on cocaine-induced locomotor sensitization in male C57BL/6 mice. The study found that subchronic repeated administration of these agonists reversed the behavioral changes associated with repeated intermittent cocaine treatment in male mice. However, these effects were not observed in female mice. The research suggests that small-molecule NOP agonists may have potential therapeutic applications for reversing the adaptive behavioral changes caused by cocaine use in males. [Extracted from the article]

A recent study conducted at the University of California Santa Cruz has found that methylphenidate, a medication commonly used to treat attention deficit hyperactivity disorder (ADHD), can alleviate cognitive dysfunction caused by early exposure to manganese. The researchers used a rat model to demonstrate that developmental manganese exposure can lead to attention and sensorimotor impairments, which were improved with oral methylphenidate treatment. The study also explored the mechanisms underlying manganese neurotoxicity and the effectiveness of methylphenidate, finding that antagonizing certain receptors had varying effects on attention and sensorimotor deficits. These findings have implications for the treatment of environmentally induced attentional and psychomotor dysfunction in children. [Extracted from the article]

A recent study conducted at the University of Toronto explored the use of ecologically relevant unconditioned stimuli (US) as effective reinforcers in appetitive conditioning for adult zebrafish. The researchers found that zebrafish showed a preference for a photograph of gravel and artificial plants placed in their tank, which served as the US. The fish were then trained using conditioned stimuli (CS) of red and blue walls, and the paired group of zebrafish showed a significant preference for the CS+ (red walls) during a memory probe trial. The study suggests that ecologically relevant stimuli can be used as efficient reinforcers in appetitive conditioning for zebrafish. [Extracted from the article]

A recent study conducted by Fukushima Medical University in Japan examined the availability of individual proteins for quantitative analysis in postmortem brains preserved in two different brain banks. The researchers compared the expression levels of two proteins, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and glial fibrillary acidic protein (GFAP), in the prefrontal cortex and superior temporal gyrus. Despite differences in demographic factors between the two institutions, no significant differences in protein expression were found. This suggests that protein quantitative analysis can be performed assuming there is no effect of difference between the two institutions. Further research is needed to explore the implications of these findings. [Extracted from the article]

A recent study conducted by Jikei University School of Medicine in Tokyo, Japan, has found an association between the early repolarization pattern (ERP) on electrocardiogram and nocturnal suicide attempts. The study examined 43 patients with a history of suicide attempts and compared their clinical backgrounds based on the presence or absence of ERP. The frequency of nocturnal suicidal behavior was higher in patients with ERP, indicating that ERP may be a biological indicator that can predict nocturnal suicide attempts. This research provides valuable insights into the relationship between mental disorders, electrocardiographic findings, and suicide risk. [Extracted from the article]

A recent study conducted in Okinawa, Japan, examined the relationship between drinking behavior patterns and depressive symptoms in patients with alcohol use disorder (AUD) after alcohol abstinence. The study found that patients who used alcohol as a coping mechanism and had low education or unemployment were more likely to experience persistent depressive symptoms after abstinence. On the other hand, patients with predominantly automatic drinking behavior were more likely to experience natural remission post-abstinence. These findings suggest that different drinking behavior patterns may have varying effects on depressive symptoms in individuals with AUD. [Extracted from the article]

A report from Nantong University in Jiangsu, China discusses the prevalence of psychiatric disorders and the challenges in treating them. The study focuses on the role of the PI3K-AKT/mTOR signaling pathway in psychiatric disorders and its potential as a therapeutic target. The researchers highlight the importance of understanding this pathway for better treatment options and identifying new therapeutic targets. The study concludes that further research on the neurobiology of this signaling pathway will contribute to a better understanding of brain development and the treatment of mental illnesses. [Extracted from the article]

A report from Nantong University in Jiangsu, China discusses the increasing prevalence of psychiatric disorders due to economic development and increased stress. The pathogenesis of these diseases is not fully understood, and current treatments have serious side effects and resistance to antipsychotics. The mammalian target of rapamycin (mTOR) pathway has been identified as a critical target for mediating the effects of antidepressants. Abnormal mTOR signaling is associated with neurodevelopmental disorders, and further research on this pathway may lead to new therapeutic targets for psychiatric disorders. [Extracted from the article]

A study conducted at Akershus University Hospital in Norway examined the use of the Visual Analogue Scale (VAS) and the Numeric Rating Scale (NRS) for measuring pain intensity in older adults. The study found that there was poor agreement between the two instruments, suggesting that they should not be used interchangeably in this population. The research was supported by various organizations and has been peer-reviewed. Further information can be obtained from the authors of the study. [Extracted from the article]

A recent report from the French Society for Biological Psychiatry and Neuropsychopharmacology and the French-speaking Marce Society provides expert recommendations on the use of psychotropic drugs for women with major depressive disorder (MDD) and bipolar disorder (BD) before, during, and after pregnancy. The recommendations were developed using a combination of scientific evidence and expert opinions. Key areas addressed in the recommendations include screening, treatment options, and monitoring for mood disorders in women of childbearing age, during pregnancy, and in the post-partum period. The guidelines aim to assist clinicians in making treatment decisions for women with mood disorders during these critical periods. [Extracted from the article]

A report from the French Society for Biological Psychiatry and Neuropsychopharmacology (AFPBN) provides updated guidelines for the management of partially responsive depression (PRD) and treatment-resistant depression (TRD). The guidelines aim to integrate newly approved treatments and nomenclatures for major depressive disorder and address risk factors associated with TRD. The recommendations combine scientific evidence and expert clinicians' opinions to bridge the gap between empirical literature and clinical practice. The guidelines also emphasize a pragmatic approach centered on the experience of specialized prescribers in TRD. [Extracted from the article]

A new report published in the International Journal of Neuropsychopharmacology explores the history, pharmacology, and potential therapeutic applications of psychedelic compounds. The researchers discuss how ancient cultures have used psychedelics for centuries, and how modern scientists are now using computational tools and behavioral metrics to study their effects on the brain. The report also highlights the gaps in current knowledge and suggests avenues for further research to better understand the physiological changes induced by psychedelics and improve therapeutic treatments. The full article can be accessed for free through the provided link. [Extracted from the article]

A recent report from Keio University School of Medicine in Tokyo, Japan discusses the development of a Japanese version of the Ego-Dissolution Inventory (EDI). The EDI is an instrument used to measure the phenomenon of ego-dissolution, which is a diminished sense of self often experienced during psychedelic-induced states. The researchers followed guidelines for translation and cultural modification to create the Japanese version of the EDI. Further studies are needed to assess the reliability and validity of this newly translated instrument. [Extracted from the article]

A recent study conducted by the University of Pennsylvania Perelman School of Medicine explored the effects of ketone supplementation on alcohol sensitivity. The study involved both human participants and rats. The results showed that ketone supplementation reduced breath alcohol concentration and blood alcohol levels in humans, as well as subjective ratings of liking and wanting more alcohol. In rats, ketone supplementation also reduced blood alcohol levels. These findings suggest that ketone supplementation may potentially reduce the intoxicating effects of alcohol. [Extracted from the article]

A recent report from Columbia University explores the effects of open access publishing on article metrics in the field of neuropsychopharmacology. The study analyzed 6,000 articles published between 2001 and 2021 and compared citation counts and Altmetric scores across three publishing tiers: Green, Bronze, and Hybrid. The findings suggest that articles with free availability on the publisher's website receive more citations, but the higher costs associated with Hybrid tier publishing may not guarantee increased scholarly or social impact. This research provides valuable insights into the relationship between publishing models and article metrics in the field of neuropsychopharmacology. [Extracted from the article]

A recent study conducted by researchers at the University of Zurich explores the potential impact of maternal prenatal psychological symptoms and saliva cortisol levels on the microbiota of neonatal meconium. The study found that lower diversity of the meconium microbiome was associated with increased maternal prenatal depressive symptoms, while higher beta diversity of the meconium samples was linked to increased saliva cortisol levels. The most abundant phylum found in the meconium samples was Pseudomonas, which was associated with maternal saliva cortisol levels. The researchers suggest that further studies are needed to understand the implications of these microbiota community alterations on child health outcomes. [Extracted from the article]

A recent study conducted at Zhengzhou University in China explored the relationship between gray matter abnormalities and the structural covariance network in individuals with obsessive-compulsive disorder (OCD). The researchers found that abnormal gray matter morphology in OCD is constrained by the normal brain network architecture. They identified specific brain regions that may serve as disease epicenters and found that other brain regions with stronger structural connections to these epicenters were more vulnerable to the disease. These findings provide new insights into the possible pathological progression of OCD. [Extracted from the article]

Research from New York University Grossman School of Medicine explores the role of acetyl-L-carnitine (LAC) in mitochondrial metabolism and its potential as an epigenetic modulator of brain plasticity. The study suggests that LAC may be a therapeutic target for depression and Alzheimer's disease, as it protects against oxidative stress, insulin resistance, and neuroinflammation. The findings highlight the potential of this mitochondrial signaling pathway as a target for therapeutic intervention in specific clinical phenotypes. The research was funded by the National Institutes of Health and published in Discover Mental Health. [Extracted from the article]

A recent study conducted by the University of Toronto examined the effects of feeding status on food consumption and learning performance in zebrafish. The researchers found that zebrafish that were fed five times a day consumed less food during habituation and training sessions compared to those fed once a day. However, the five-times-a-day-fed fish showed enhanced learning and memory performance, as they swam closer to the conditioned stimulus during a post-training probe trial. The study concluded that elevated chronic feeding improved food consumption and learning performance in adult zebrafish without affecting their activity levels. [Extracted from the article]

A study conducted by researchers at Peking University in Beijing, China, explores the role of melanin-concentrating hormone (MCH) in the locus coeruleus (LC) in depression-like behaviors in rats. The study found that chronic stress led to an increase in MCH levels and a decrease in MCH receptor 1 (MCHR1) in the LC, which correlated with the development of depression-like behaviors. The researchers also discovered that blocking MCHR1 in the LC reversed the downregulation of norepinephrine production induced by MCH, suggesting that the MCH/MCHR1 system in the LC may be involved in depression. These findings contribute to our understanding of the pathogenesis of depression. [Extracted from the article]

A recent study conducted by the University of the Ryukyus in Okinawa, Japan, examined the associations between drinking behavior patterns and relapse in patients with alcohol use disorder (AUD). The study found that habitual behaviors, rather than goal-oriented behaviors, primarily characterize drinking patterns in individuals with AUD. The research identified several factors associated with relapse, including being a current smoker, living alone, and engaging in automatic drinking habits. The findings suggest that addressing automatic drinking behaviors may be crucial in preventing relapse among individuals with AUD. [Extracted from the article]

A recent randomized clinical trial published in Neuropsychopharmacology Reports suggests that repetitive transcranial magnetic stimulation (rTMS) may help improve certain aspects of prospective memory in individuals with schizophrenia. Prospective memory refers to the ability to remember to perform future activities. The trial included 50 patients with schizophrenia and 18 healthy controls, and the results showed that event-based prospective memory scores in patients significantly improved after rTMS treatments and were similar to those in controls. However, time-based prospective memory scores did not improve. These findings provide a potential therapeutic option for prospective memory in patients with schizophrenia. [Extracted from the article]

A report from the Kurume University School of Medicine in Fukuoka, Japan, discusses the increasing use of hypnotic drugs for insomnia treatment in Japan and the issue of over-dependence on these drugs. The study examined the factors related to the elimination of prescriptions of three or more hypnotic drugs within one year in their clinic. The research found that the frequency of prescribing three or more hypnotic drugs was higher in psychiatry compared to other departments, and identified age, trazodone addition, and years of psychiatric experience as success factors for reducing drug use. The study's findings may contribute to addressing the problem of multiple prescriptions of hypnotic drugs. [Extracted from the article]

A study conducted at the Medical University of Vienna explored the relationship between DNA methylation and protein expression in the brain. Specifically, the researchers investigated the impact of DNA methylation in the MAOA gene on the density of monoamine oxidase A (MAO-A), a protein associated with depression. The study found that while DNA methylation did affect peripheral protein expression, it did not significantly influence MAO-A density in the brain. However, the researchers did observe a seasonal effect on DNA methylation levels in women. This study contributes to our understanding of the role of epigenetic modifications in neurobiology and provides insights into the serotonergic system's seasonal effects. [Extracted from the article]

A recent study conducted at the University of Alberta in Canada has found that perimenopause is associated with a decreased level of gamma-aminobutyric acid (GABA) in the medial prefrontal cortex (MPFC) of women. This decrease in GABA levels may contribute to the increased risk of developing a major depressive episode during perimenopause. The study compared GABA levels in the MPFC of perimenopausal women and healthy reproductive-aged women and found that the perimenopausal group had lower GABA levels. However, when age was taken into account, the difference in GABA levels between the two groups was no longer significant. This research provides insight into the unique pathophysiology of perimenopausal depression. [Extracted from the article]

A recent study conducted by the University of the Ryukyus in Okinawa, Japan, examined the cognitive impairments in patients with alcohol use disorder (AUD) and the factors that contribute to them. The study recruited 97 inpatients with AUD who initially showed normal cognitive function. After a 4-week post-abstinence period, cognitive function was assessed using the Brief Assessment of Cognition in Schizophrenia-Japanese version (BACS-J). The study found that age and total bilirubin level were worsening factors for cognitive decline, while education was a protective factor. Patients with AUD aged 53 years and older showed more pronounced impairments in various cognitive domains. The findings suggest the importance of early intervention in AUD patients to prevent progressive cognitive decline and preserve their quality of life. [Extracted from the article]

A recent study conducted at the University of Alabama Birmingham explored the role of N6-methyladenosine (m6A) RNA methylation in the regulation of plasticity-related genes in the hippocampus of rats with stress-induced depression. The researchers found that rats with learned helplessness, a model of depression, exhibited downregulation of plasticity genes and increased m6A methylation of these genes. They also observed alterations in the expression of m6A-modifying enzymes and DNA methylation enzymes. Additionally, the study identified a potential mechanism involving the miR-124-C/EBP-alpha-FTO axis, which may contribute to abnormal neuronal plasticity in depression. This research provides new insights into the epitranscriptomic modifications underlying depression and may have implications for future therapeutic interventions. [Extracted from the article]

A recent study conducted in Ukraine and Germany explored the experiences of recovering alcohol-dependent patients with insomnia and their preferences for treatment strategies. The study involved semi-structured interviews with 27 patients, revealing that most of them experienced negative psychological and physiological effects, as well as negative daytime consequences, due to insomnia. The patients used both nonpharmacological and pharmacological approaches to manage their insomnia. This research provides valuable insight into how alcohol-dependent patients in recovery perceive and cope with insomnia. [Extracted from the article]

Keywords: Drugs and Therapies; Health and Medicine; Neuropsychopharmacology; Therapy EN Drugs and Therapies Health and Medicine Neuropsychopharmacology Therapy 2670 2670 1 11/06/23 20231110 NES 231110 2023 NOV 10 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Researchers detail new data in drugs and therapies. Drugs and Therapies, Health and Medicine, Neuropsychopharmacology, Therapy. [Extracted from the article]

By 1977, these were the most prescribed medicines globally; they are still regarded as reasonably safe and effective (although some patients developed tolerance, and became dependent on the drugs, while the risk of falls and fractures remains a concern in older people). Keywords: Anxiety; Anxiety Disorders; Ativan Therapy; Diazepam Therapy; Drugs and Therapies; European College of Neuropsychopharmacology; Health and Medicine; Hip Fracture; Lorazepam Therapy; Mental Health Diseases and Conditions; Neuropsychopharmacology; Pharmaceuticals; Risk and Prevention; Therapy; Valium Therapy EN Anxiety Anxiety Disorders Ativan Therapy Diazepam Therapy Drugs and Therapies European College of Neuropsychopharmacology Health and Medicine Hip Fracture Lorazepam Therapy Mental Health Diseases and Conditions Neuropsychopharmacology Pharmaceuticals Risk and Prevention Therapy Valium Therapy 1077 1077 1 10/24/23 20231027 NES 231027 2023 OCT 27 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Type of work: peer reviewed/ observational study/ people More than 60 years after being introduced, doctors have uncovered the first reliable evidence to confirm the belief that taking benzodiazepines such as Valium and Ativan intermittently rather than continuously is associated with fewer side effects and reduced falls, hospitalisations and deaths Benzodiazepines such as Ativan, Librium and Valium were first used to treat anxiety and insomnia in the early 1960's. Dr Davies continued "This work shows that where possible, patients over the age of 65 with anxiety or insomnia who are taking Ativan, Valium or another benzo long-term would better not to stay on the drugs continuously. [Extracted from the article]