Researchers from Peking University Report Findings in Neuro-Psychopharmacology (Taar1 In Dentate Gyrus Is Involved In Chronic Stress-induced Impairments In Hippocampal Plasticity and Cognitive Function).

Researchers from Peking University in Beijing, China have conducted a study on the role of the trace amine-associated receptor 1 (TAAR1) in chronic stress-induced impairments in hippocampal plasticity and cognitive function. The study used genetic approaches, behavioral tests, and immunohistochemical staining to investigate the effects of TAAR1 on dentate neuronal plasticity and cognitive function in mice subjected to chronic social defeat stress. The results showed that chronic stress led to decreased TAAR1 levels in the dentate gyrus, as well as compromised social memory, impaired proliferation and maturation of adult-born dentate granule cells, and cognitive function deficits. However, the administration of a selective TAAR1 partial agonist attenuated these adverse effects. The researchers concluded that TAAR1 agonists may have therapeutic potential for individuals with cognitive impairments associated with major depressive disorder. [Extracted from the article]