Reports on Neuro-Psychopharmacology from Western University of Health Sciences Provide New Insights (Small Molecule Nop Agonists Reverse Locomotor Sensitization Induced By Cocaine In Male C57bl/6 Mice).

A recent report from the Psychology & Psychiatry Journal discusses research conducted at the Western University of Health Sciences on the effects of small-molecule NOP agonists on cocaine-induced locomotor sensitization in male C57BL/6 mice. The study found that subchronic repeated administration of these agonists reversed the behavioral changes associated with repeated intermittent cocaine treatment in male mice. However, these effects were not observed in female mice. The research suggests that small-molecule NOP agonists may have potential therapeutic applications for reversing the adaptive behavioral changes caused by cocaine use in males. [Extracted from the article]