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A recent study conducted at the University of Georgia focused on the molecular characterization of an infectious bursal disease virus (IBDV) strain from an outbreak in layer chickens in Ghana. The research identified the presence of IBDV in formalin-fixed paraffin-embedded tissues through reverse transcription polymerase chain reaction (RT-PCR) and sequencing of the VP2 gene. The study placed the Ghanaian IBDV in genogroup 3 (vvIBDV), closely related to IBDV from Nigeria, with specific amino acid substitutions. This research provides valuable insights into the genetic characteristics of IBDV strains associated with outbreaks in poultry populations. [Extracted from the article]

Researchers from the Agriculture Research Center in Cairo, Egypt, conducted a study on infectious bursal disease virus strains in Egyptian poultry. They found that variant strains were more pathogenic and immunosuppressive compared to very virulent strains, highlighting the need for effective control measures. The study identified specific strains and their effects on chickens, emphasizing the importance of understanding the molecular characteristics of infectious bursal disease virus for vaccine efficacy. [Extracted from the article]

A study conducted in Parana, Brazil, by Phibro Animal Health Corporation examined the impact of genogroup 4 Infectious Bursal Disease Virus (dIBDV) on vaccinated broiler flocks. The research found that dIBDV can cause health and productivity losses in broilers, with infected flocks experiencing higher mortality rates and worsened feed conversion. The study highlights the importance of monitoring viral variants to prevent outbreaks and improve disease control strategies in the region. [Extracted from the article]

A study conducted by the Chinese Academy of Agricultural Sciences in Harbin, China, has provided new insights into the immune escape of the emerging novel variant of the Infectious Bursal Disease Virus (IBDV). The research found that specific residues in the viral capsid protein are involved in the immune escape of the virus. The study suggests that these findings could help in the design of novel vaccines that match the antigen of the epidemic strain. The research was funded by the National Natural Science Foundation of China and the National Key Research & Development Program of China. [Extracted from the article]

Researchers from the University of Padova in Italy have conducted a study on the infectious bursal disease virus (IBDV), which is a significant burden for poultry production and market due to disease and immunosuppression. The study evaluated the expression of different cytokines in the bursa of Fabricius and thymus during a 28-day-long experimental infection with two strains of IBDV. The results showed that the G6 strain induced a delayed immune response or suppressed it more promptly compared to the G1a strain. The study suggests the importance of longer monitoring activities after infection to better understand the complex patterns and interactions with the host response. [Extracted from the article]

This article discusses a patent issued to Zoetis Services LLC for the development of recombinant herpesvirus of turkey vectors that express antigens of avian pathogens. The patent aims to create multivalent vaccines that provide immunity against multiple diseases in poultry. The invention involves inserting foreign genes into the genome of the herpesvirus of turkey to elicit an immune response and protect against various pathogens. The recombinant vectors have the advantages of both live and killed vaccines, providing longer-lasting immunity with milder reactions. The patent also mentions the use of the herpesvirus of turkey as a vaccine vector for Marek's disease, a highly contagious avian infection. The patent describes a recombinant Herpesvirus of Turkey (HVT) genome that has been modified to include genetic material from Infectious Bursal Disease Virus and Newcastle Disease Virus. The modified genome contains nucleotide sequences that code for specific antigens from these viruses. The patent also mentions the use of promoters and poly A signals in the modified genome. The recombinant HVT genome can be used to produce a vaccine composition that can help prevent Infectious Bursal Disease, Newcastle Disease, and Marek's Disease in birds. The vaccine can be administered through various routes, such as spray administration, in ovo administration, subcutaneous administration, intramuscular administration, oral administration, or nasal administration. [Extracted from the article]

A recent study conducted by researchers at the University of Padova in Italy has identified a novel variant of the infectious bursal disease virus (IBDV) in Egypt. The IBDV is a highly resistant RNA virus that causes immunosuppressive disease in poultry. The study found that this emerging genotype, known as A2dB1b, has been detected for the first time outside of Eastern and Southern Asia. The spread of this variant to Egypt is concerning, as current commercial vaccines may not provide optimal protection against it. These findings are important for monitoring and controlling the spread of the novel variant IBDVs and minimizing their impact. [Extracted from the article]

A recent study conducted by researchers at Tianjin University in China explored the potential of using Saccharomyces cerevisiae, a type of yeast, as an oral vaccine for infectious bursal disease (IBD) in poultry. IBD is a highly infectious immunosuppressive disease that causes significant economic losses in the poultry industry. The researchers constructed a recombinant S. cerevisiae strain that expressed the capsid protein VP2 of the IBD virus and found that it elicited high levels of specific antibodies in mice, indicating potential efficacy in preventing IBDV infection. This study suggests that S. cerevisiae could be a promising candidate for an oral subunit vaccine against IBDV. [Extracted from the article]

A report from Northeast Agricultural University in Harbin, China discusses the development and evaluation of a bivalent vaccine for Newcastle disease (ND) and infectious bursal disease (IBD), two viral diseases that are harmful to the poultry industry. The researchers developed a vaccine called rClone30-VP2L-CH3-CH4-GMCSF, which was tested on specific pathogen-free (SPF) chickens. The results showed that the vaccine stimulated a stronger immune response and increased antibody levels compared to other vaccines. However, the addition of CH3-CH4 did not improve the vaccine's immune effect as expected. The research lays the foundation for developing vaccines for other viral diseases. [Extracted from the article]

Researchers from the Chinese Academy of Fishery Sciences have discovered that the traditional Chinese medicine compound bufalin exhibits anti-Infectious Pancreatic Necrosis Virus (IPNV) activity. IPNV is a pathogen that causes high mortality and economic losses in salmon and trout aquaculture. Bufalin was found to inhibit infections from IPNV genogroups I and V by blocking viral internalization and RNA replication. In vivo experiments showed that bufalin significantly reduced viral loads in IPNV-targeted tissues in rainbow trout. This research suggests that bufalin may be a promising drug for treating IPNV infections. [Extracted from the article]

A new study has been published on infectious bursal disease virus (IBDV), a highly contagious virus that affects poultry. The study focused on an outbreak of IBDV in California in 2009 and aimed to uncover the molecular factors contributing to the virulence of the virus. The researchers conducted whole genome sequencing of the virus and identified specific genetic markers associated with virulence. These findings provide important insights into the evolution and virulence factors of IBDV and can aid in the development of control strategies for early detection of novel strains. [Extracted from the article]

Asia, Avibirnavirus, Birnaviridae, China, Enzymes and Coenzymes, Infectious Bursal Disease Virus, Polymerase, RNA Viruses Keywords: Asia; Avibirnavirus; Birnaviridae; China; Enzymes and Coenzymes; Infectious Bursal Disease Virus; Polymerase; RNA Viruses EN Asia Avibirnavirus Birnaviridae China Enzymes and Coenzymes Infectious Bursal Disease Virus Polymerase RNA Viruses 1669 1669 1 08/14/23 20230818 NES 230818 2023 AUG 18 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- New study results on infectious bursal disease virus have been published. [Extracted from the article]

Asia, Birnaviridae, Avibirnavirus, China, Infectious Bursal Disease Virus, RNA Viruses Keywords: Asia; Avibirnavirus; Birnaviridae; China; Infectious Bursal Disease Virus; RNA Viruses EN Asia Avibirnavirus Birnaviridae China Infectious Bursal Disease Virus RNA Viruses 1434 1434 1 04/03/23 20230407 NES 230407 2023 APR 7 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Investigators discuss new findings in infectious bursal disease virus. [Extracted from the article]

For more information on this research see: Development of a Recombinant Adenovirus-vectored Vaccine Against Both Infectious Hematopoietic Necrosis Virus and Infectious Pancreatic Necrosis Virus In Rainbow Trout (Oncorhynchus Mykiss). Keywords: Shanghai; People's Republic of China; Asia; Adenovirus; Aquabirnavirus; Birnaviridae; DNA Viruses; Genetics; Immunology; Infectious Hematopoietic Necrosis Virus; Infectious Pancreatic Necrosis Virus; Mononegavirales; Novirhabdovirus; RNA Viruses; Rhabdoviridae; Risk and Prevention; Vertebrate Viruses EN Shanghai People's Republic of China Asia Adenovirus Aquabirnavirus Birnaviridae DNA Viruses Genetics Immunology Infectious Hematopoietic Necrosis Virus Infectious Pancreatic Necrosis Virus Mononegavirales Novirhabdovirus RNA Viruses Rhabdoviridae Risk and Prevention Vertebrate Viruses 3669 3669 1 03/24/23 20230224 NES 230224 2023 FEB 24 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Research findings on RNA Viruses - Infectious Pancreatic Necrosis Virus are discussed in a new report. [Extracted from the article]