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A recent study conducted at Fukuoka Dental College in Japan explored the role of FANCD2 in counteracting O6-methylguanine-induced mismatch repair-dependent apoptosis. The research found that FANCD2 is crucial for recruiting homologous recombination factors to resolve replication stress and prevent apoptosis triggered by O6-methylguanine. This study sheds light on the molecular mechanisms underlying apoptosis and DNA damage response, offering valuable insights into cellular physiology and health. [Extracted from the article]

Researchers from Kyushu Dental University in Fukuoka, Japan, have conducted a literature review on treatment strategies for dental implant removal. The study highlights the causes of early and late implant failure, emphasizing patient-related factors like smoking and diabetes. The research suggests that implants should be removed if they are mobile or if there is peri-implantitis, with a focus on patient-specific issues before reimplantation. The study concludes that controlling factors like smoking habits and bruxism is crucial for successful reimplantation. [Extracted from the article]

A recent study conducted by Kyushu University in Fukuoka, Japan, focused on the characterization of two bacteriophages targeting Campylobacter jejuni, a common cause of foodborne illness. The research found that these phages, when combined with EDTA, effectively reduced C. jejuni contamination in food products. While the phages showed promise in inhibiting bacterial growth, they were not directly applicable for food safety due to being lysogenic. This study contributes to expanding the genome library of C. jejuni phages and offers potential strategies for controlling the bacteria. [Extracted from the article]

A recent study conducted by Kyushu University in Fukuoka, Japan, explored the impact of mucilage and low omega-3 fatty acid contents in phytoplankton on the dietary quality for zooplankton, specifically Daphnia pulicaria. The research found that phytoplankton with mucilage had decreased dietary quality, particularly among green algae, while those without mucilage had higher omega-3 fatty acid contents, enhancing their quality as a diet for zooplankton. The presence of mucilage was shown to reduce ingestion and digestion by zooplankton, potentially negatively impacting lake ecosystems. This peer-reviewed study sheds light on the importance of understanding the composition of phytoplankton diets for maintaining ecological balance. [Extracted from the article]

A recent study conducted at Kyushu University Hospital in Fukuoka, Japan, focused on new treatment strategies for patients with advanced non-small cell lung cancer (NSCLC) who have low PD-L1 expression. The study highlighted the potential benefits of combining Datopotamab deruxtecan (Dato-DXd) with pembrolizumab and platinum-based chemotherapy in this patient population. The research aims to evaluate the efficacy of this combination therapy in improving progression-free survival and overall survival outcomes for patients with non-squamous NSCLC. Financial support for the study was provided by Daiichi Sankyo Company Limited, AstraZeneca, and Merck & Company. [Extracted from the article]

A study conducted at Kurume University Hospital in Fukuoka, Japan, explored the role of CXCR4 expression and cancer-associated fibroblasts in the invasion of low-grade endometrioid carcinoma. The research found that CXCR4 expression significantly reflected myometrial invasion in endometrioid carcinoma cases, indicating its potential as an independent factor in diagnostic evaluation before treatment. This study sheds light on the heterogeneous behavior of well-differentiated endometrioid carcinoma and highlights the importance of accurate evaluation for treatment strategies, especially in cases considering fertility preservation. [Extracted from the article]

A study conducted at Kyushu University in Fukuoka, Japan, focused on the clinical significance of the tumor immune microenvironment in endometrial endometrioid carcinoma, grade 1, with DNA mismatch repair protein loss. The research highlighted the impact of the tumor immune microenvironment on clinicopathological features within the group with mismatch repair protein loss, which is the main target for immune checkpoint inhibitors in endometrioid carcinoma, grade 1. The study emphasized the need for further research, including on patients who have been administered immune checkpoint inhibitors. [Extracted from the article]

Researchers at Fukuoka University in Japan conducted a study on the development of subchondral insufficiency fracture of the femoral head in individuals with and without osteoporosis. Using finite element model analysis, they found that torsional force may play a significant role in the development of these fractures. The study concluded that torsion could be a key force responsible for subchondral insufficiency fracture development. This research has been peer-reviewed and provides valuable insights into the mechanisms behind this type of fracture. [Extracted from the article]

A study conducted at Kyushu University Hospital in Fukuoka, Japan, explored the effects of acute dapagliflozin administration on cardiac surgery-associated acute kidney injury in a rabbit model. The research found that dapagliflozin administration led to reduced serum creatinine and blood urea nitrogen concentrations, increased urine output, and improved tubular injury scores. The study concluded that dapagliflozin may have direct renoprotective effects in renal tubular cells. This research was published in the Circulation Journal and has been peer-reviewed. [Extracted from the article]

A study conducted at the Japanese Red Cross Fukuoka Hospital focused on optimizing guideline-directed medical therapy (GDMT) during hospitalization for patients with heart failure. The research found that higher GDMT scores at discharge were associated with improved prognosis in heart failure patients, particularly those requiring readmissions. By analyzing 1,222 heart failure patients with reduced ejection fraction, the study revealed that improving in-hospital GDMT scores was linked to better outcomes, emphasizing the importance of interventions and score elevation during hospitalization. The findings suggest that enhancing GDMT optimization could lead to improved prognosis for patients with worsening heart failure. [Extracted from the article]

Researchers from Kyushu University in Fukuoka, Japan, have conducted a study on the fabrication and histological evaluation of a self-setting granular cement using calcium sulfate hemihydrate granules with different pore distribution. The research aimed to address the issue of migration of granules used in bone substitutes by investigating the setting ability of calcium sulfate. After 4 weeks of implantation, the granules showed the ability to set within bone defects, although no significant differences were observed in bone regeneration. This peer-reviewed study provides insights into designing effective bone substitutes to prevent granule migration. [Extracted from the article]

Researchers at Kyushu University conducted a study on osteonecrosis of the femoral head, focusing on the effects of the location of both anterior and lateral boundaries of the necrotic lesion on collapse progression. The study found that the location of these boundaries is crucial in predicting collapse progression, especially in hips with specific types of necrotic lesions. The research was supported by Grants-in-Aid for Scientific Research and has been peer-reviewed. For more information, the study was published in the Journal of Orthopaedic Science. [Extracted from the article]

Researchers from the University of Occupational and Environmental Health in Fukuoka, Japan, conducted a study on iron overload induced by tocilizumab, an anti-interleukin-6 receptor antibody, in a 75-year-old woman with rheumatoid arthritis. The patient developed liver dysfunction one year after starting tocilizumab treatment, leading to a diagnosis of hepatic iron overload. Ceasing tocilizumab and undergoing phlebotomy improved the patient's liver function, highlighting the importance of monitoring iron status in patients receiving tocilizumab. The research emphasizes the need to be cautious of tocilizumab-induced iron overload in susceptible individuals. [Extracted from the article]

A study conducted at Fukuoka University in Japan analyzed blood samples from patients who engaged in deliberate self-harm (DSH) to compare prescribed medications with detected drugs. The research found that approximately 80% of the DSH patients had taken non-prescribed drugs (NPD), highlighting a significant difference between prescribed medications and those found in the blood. This study is the first to focus on drug analysis in DSH patients, shedding light on the prevalence of NPD use in this population. [Extracted from the article]

Researchers at the Spinal Injuries Center in Fukuoka, Japan, conducted a study to identify a reliable sacral-sparing examination to assess the Asia Impairment Scale in patients with traumatic spinal cord injury. The study focused on participants with complete paralysis within 72 hours of injury and found that the S4-5LT examination showed the highest agreement and correlation with AIS determination, indicating its importance in distinguishing complete from incomplete paralysis. This research, which has been peer-reviewed, provides valuable insights into assessing spinal cord injuries and was published in the Journal of Spinal Cord Medicine. [Extracted from the article]

A recent study conducted at Kyushu University in Fukuoka, Japan, focused on the development of regioselective C-H trifluoromethylation and related reactions of (hetero)aromatic compounds. The research aimed to introduce fluorinated functional groups into these compounds, which are crucial for drug development and organic materials. The study successfully achieved these reactions with high yields and functional group tolerance, making them applicable to drug molecules. Financial support for the research came from various foundations and agencies, and the findings were published in a peer-reviewed journal. [Extracted from the article]

Researchers at Kyushu University in Fukuoka, Japan, have conducted a study on Mandibulofacial Dysostosis, specifically focusing on the clinical severity of the Guion-Almeida type. The study aimed to establish a genotype-phenotype correlation in patients with this condition, particularly looking at the influence of genetic variants in the EFTUD2 gene. The research found that while there was no clear genotype-phenotype correlation overall, Asians tended to exhibit more severe clinical manifestations compared to White people, with cardiac abnormalities being a predisposing factor for increased severity. This study provides valuable insights into the pathogenic variants of EFTUD2 and potential genotype-phenotype relationships in Mandibulofacial Dysostosis. [Extracted from the article]

A recent report from Kyushu University discusses the impact of energy poverty on the mental health of school-aged children in energy-poor countries, particularly in South Asia and Sub-Saharan Africa. The study reveals a significant association between energy poverty and increased levels of anxiety and depression among children, as well as a concerning link to child abuse. The findings emphasize the need for targeted interventions and policies to address the adverse mental health effects of energy poverty on children in these regions. [Extracted from the article]

A study conducted at Saiseikai Fukuoka General Hospital in Japan focused on the prognostic impact of the lymphocyte-to-C-reactive protein ratio (LCR) in patients who underwent surgical resection for pancreatic cancer. The research found that a low preoperative LCR was associated with poorer recurrence-free survival and overall survival rates in patients with pancreatic cancer. The study suggests that patients with low LCR may benefit from more intensive therapy, highlighting the potential of preoperative LCR as a novel prognostic marker for pancreatic cancer patients. [Extracted from the article]

Researchers at Kyushu University in Fukuoka, Japan, have conducted a study on Xeroderma Pigmentosum, a genetic skin disease. The study focused on the use of triamcinolone acetonide for treating hypertrophic scars associated with the condition. The research highlighted the advantages of transdermal delivery of the medication to reduce side effects and improve therapeutic efficacy. This peer-reviewed study provides valuable insights into the treatment of Xeroderma Pigmentosum and can be accessed through the European Journal of Dermatology. [Extracted from the article]

A study conducted at Kyushu University in Fukuoka, Japan, focused on the prevalence and predisposing factors of neuropathic pain in patients with rotator cuff tears. The research found that 7.2% of patients with rotator cuff tears experienced neuropathic pain. Factors such as the VAS score and UCLA shoulder score were identified as independent predictors of neuropathic pain. The study emphasized the importance of assessing neuropathic pain in patients with painful rotator cuff tears to improve patient outcomes. [Extracted from the article]

Researchers from Kyushu University in Fukuoka, Japan, have developed a high-quality 60 GHz lumped element transmission line using cascaded T-networks for millimeter wave applications. The design equations for this transmission line configuration were derived, showing that implementing three or more cascaded T-networks can achieve additional miniaturization. The fabricated transmission line demonstrated good agreement between measured and simulated results, with a quality factor of 17 at 60 GHz. This study contributes to advancements in electronics engineering, particularly in the field of miniaturized transmission lines for high-frequency applications. [Extracted from the article]

A study conducted at Kyushu University in Fukuoka, Japan, explored implicit attitudes towards Autism Spectrum Disorder (ASD) in university students compared to attitudes towards physical disabilities. The research found that university students exhibited less negative implicit attitudes towards ASD than towards physical disabilities. The study suggests that the appearance of individuals with ASD may lead to them being evaluated more positively as 'in-group' members, contributing to the less negative attitudes observed. This peer-reviewed research provides valuable insights into societal perceptions of ASD and physical disabilities. [Extracted from the article]

A recent study conducted by Kyushu University in Fukuoka, Japan, focused on enhancing the antimicrobial properties of sodium alginate film used in food packaging. By incorporating peppermint essential oil and Japanese rice vinegar into the film, researchers observed improved prevention of fungal growth and spore germination. The combination of vinegar and essential oil was found to be particularly effective in enhancing the performance of food packaging, as reported in the International Journal of Biological Macromolecules. For more information, readers can contact Leila Mohammadi at Kyushu University in Japan. [Extracted from the article]

A study conducted at the National Hospital Organization Kyushu Medical Center in Fukuoka, Japan, explored predictors for the clinical efficacy of tramadol in managing cancer pain. The research found that elderly patients with good performance status and liver function were more likely to benefit from tramadol therapy. The study, which involved 183 patients, concluded that tramadol could be an effective and cost-saving option for cancer pain management. The findings were published in the American Journal of Hospice and Palliative Medicine. [Extracted from the article]

A study conducted by Kyushu University in Fukuoka, Japan, explored the early pathogenesis of diabetic retinopathy (DR) and the potential protective effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors. The research found that SGLT2 inhibitors could prevent early pathogenic mechanisms of DR, including retinal vascular leakage and morphological changes in microglia. This study sheds light on potential treatments for DR and was funded by various organizations, including the Japan Society for the Promotion of Science. [Extracted from the article]

A recent study from Kyushu University in Fukuoka, Japan, focused on primary intraosseous carcinoma NOS (PIOC), a rare type of odontogenic tumor with a poor prognosis. The research highlighted the transition from odontogenic keratocyst to carcinoma in PIOC, emphasizing the malignant attributes of the tumor. The study suggested that the activation of YAP signaling by Wnt/(3-catenin signaling may play a role in the pathogenesis of PIOC. [Extracted from the article]

A recent study conducted by Kyushu University Graduate School in Fukuoka, Japan, focused on producing Norovirus virus-like particles (VLPs) of nine genotypes prevalent in Japan using the silkworm-baculovirus expression vector system. The research aimed to develop a multivalent vaccine against genetically diverse Norovirus infections, as the virus is a major cause of acute viral gastroenteritis in humans. The study successfully demonstrated the utility of the silkworm-BEVS in producing VLPs of multiple genotypes, laying the groundwork for potential vaccine development. The research has been peer-reviewed and offers valuable insights into combating Norovirus infections. [Extracted from the article]

A study conducted by investigators from Kyushu University in Japan examined Chinese consumers' responsiveness towards contaminated imported cold chain seafood, specifically focusing on the role of trust in government information, risk perception, and risk preferences on purchasing behavior. The research found that the interaction between risk perception and risk preference positively influenced actual purchasing behavior, while trust in government information did not directly impact consumer behavior. Subgroup regressions revealed city heterogeneity in the effect of trust in government information on purchasing behavior. This peer-reviewed study sheds light on the complex factors influencing consumer decisions in the context of food safety and contamination issues. [Extracted from the article]

A study conducted at Fukuoka Women's University in Japan examined the association between meat intake and type 2 diabetes among Japanese workers. The research found that total meat, red meat, processed meat, and poultry intake were not linked to an increased risk of type 2 diabetes in this population. The study concluded that meat intake is not associated with the risk of type 2 diabetes among Japanese workers. [Extracted from the article]

Researchers at Fukuoka University conducted a prospective cohort study to assess the incidence and clinical outcomes of lateral femoral cutaneous nerve (LFCN) injury after periacetabular osteotomy (PAO) over a minimum three-year follow-up period. They found that 50% of patients experienced symptoms of LFCN injury one year after PAO, with 33% still experiencing symptoms at three years postoperatively. Patients with persistent symptoms had poorer outcomes in terms of patient satisfaction and mental health scores. The study highlights the high incidence of LFCN injury after PAO and its impact on long-term clinical outcomes. [Extracted from the article]

A study conducted by Kyushu University in Fukuoka, Japan, aimed to evaluate the responsiveness of a culturally relevant Japanese version of the knee injury and osteoarthritis outcome score (JKOOS+). The study enrolled 114 patients scheduled for total knee arthroplasty (TKA) and found that the JKOOS+ was adequately responsive in assessing patient outcomes after TKA. The study also found that the novel Japanese ADL (JADL) domain outperformed the Europe-developed ADL domain in responsiveness. The research concluded that the JKOOS+ is a valuable tool for evaluating outcomes in Japanese knee patients undergoing TKA. [Extracted from the article]

A study conducted by researchers from Kyushu University in Fukuoka, Japan, aimed to validate a Japanese version of the Algoplus (R) tool for assessing postoperative pain in older Japanese patients with cancer. The study found that the Japanese version of Algoplus (R) is a reliable and valid instrument for nurses to assess acute postoperative pain in older Japanese patients with cancer. The scale demonstrated good internal consistency and inter-rater reliability, and it showed good responsiveness for detecting changes in pain status. The research was supported by the Japan Society for the Promotion of Science and has been peer-reviewed. [Extracted from the article]

A recent study conducted by researchers at Kyushu University in Fukuoka, Japan, examined the effectiveness of using a backboard during cardiopulmonary resuscitation (CPR) on patients in bed. The study found that using a backboard resulted in deeper manual chest compressions (MCC) and improved success rates on various types of mattresses. However, the study also recommended performing MCC on the floor when possible, considering factors such as manpower, environment, time, and patient condition. The research has been peer-reviewed and provides valuable insights for healthcare professionals in the field of intensive care and emergency medicine. [Extracted from the article]

A report from Kyushu University in Fukuoka, Japan, discusses a direct replication study of a previous experiment by Casasanto (2009) on the body-specificity hypothesis. The original study found that right-handed individuals tend to associate positive valence with the right side and negative valence with the left side, while left-handed individuals show the opposite pattern. The replication study involved 2,222 participants from 12 countries and confirmed Casasanto's findings. The research supports the idea that there is a body-specific space-valence mapping. This research has been peer-reviewed and published in the journal Memory & Cognition. [Extracted from the article]

A recent report from Kyushu University Hospital in Fukuoka, Japan, explores the presence of microstructural changes in the white matter tracts of first-degree relatives of patients with Obsessive-Compulsive Disorder (OCD). The study used diffusion-tensor magnetic resonance imaging (DTI) data from 29 first-degree relatives and 59 healthy controls. The findings indicate that any alterations in the white matter microstructure of first-degree relatives, which could potentially serve as vulnerability markers for OCD, are likely to be subtle. This research has been peer-reviewed and published in Psychiatry Research Neuroimaging. [Extracted from the article]

A study conducted at Takagi Hospital in Fukuoka, Japan aimed to evaluate gender differences in adverse events, gastrointestinal bleeding, and bone fractures among hemodialysis patients with end-stage renal failure. The study included 151 patients, divided into a female group of 61 and a male group of 90. The results showed that diabetes mellitus-induced end-stage renal failure was less common in females, and the mortality rate during hemodialysis was higher in males under 75 years old with lower bone fractures. The study concluded that female patients with end-stage renal failure treated by hemodialysis had a low mortality rate compared to male patients. [Extracted from the article]

A study conducted by researchers at Kyushu University in Fukuoka, Japan, aimed to assess the relationship between histopathological features of gastric cancer and the extracellular volume fraction (ECV) measured by preoperative equilibrium contrast-enhanced computed tomography (CECT). The study included 66 patients with surgically resected gastric adenocarcinoma who underwent preoperative multiphasic CECT. The results showed that tumor ECV determined by equilibrium CECT is significantly correlated with the pathological infiltration pattern of gastric cancer. This research provides new insights into the diagnosis and understanding of gastric cancer. [Extracted from the article]

A recent study conducted by researchers at Kyushu University in Fukuoka, Japan, examined the impact of early defibrotide (DF) therapy on pediatric patients with veno-occlusive disease (VOD) or sinusoidal obstruction syndrome (SOS) after stem cell transplantation. The study found that VOD/SOS occurred more frequently in the post-DF era, particularly in patients with relapsed/refractory acute lymphoblastic leukemia. Early DF therapy was shown to reduce the severity of VOD/SOS and improve survival outcomes. The researchers noted that the incidence of VOD/SOS is increasing in the era of immunotherapy for progressive diseases. [Extracted from the article]